NOVEL DRUG DELIVERY STRATEGIES FOR ANTI HIV DRUGS

Overactive bladder syndrome (OAB) is characterised by urgency symptoms, with or without urgency incontinence, usually with frequency and nocturia and severely affects the quality of life. This systematic review evaluates the various drug delivery strategies used in practice to manage OAB. Advanced drug delivery strategies alongside traditional strategies were comprehensively analysed and comparatively evaluated. The present review was conducted according to the preferred reporting items for systematic reviews and meta-analyses guidelines. A total of 24 studies reporting the development of novel formulations for the treatment of OAB were considered eligible and were further categorised according to the route of drug administration. The review found that various drug delivery routes (transdermal, intravesicular, oral, vaginal and intramuscular) are used for the administration of drugs for managing OAB, however, the outcomes illustrated the marked potential of transdermal drug delivery route. The findings of the current review are expected to be helpful for pharmaceutical scientists to better comprehend the existing literature and challenges and is anticipated to provide a basis for designing and fabricating novel drug delivery systems to manage OAB.

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Recent Developments and Novel Drug Delivery Strategies for the Treatment of Tuberculosis

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2019.12.3.2 ◽

2019 ◽

Vol 12 (3) ◽

pp. 4524-4530

Author(s):

Yonas Brhane ◽

Tesfaye Gabriel ◽

Tigist Adane ◽

Yemisrach Negash ◽

Henok Mulugeta ◽

...

Keyword(s):

Drug Delivery ◽

Mycobacterium Tuberculosis Complex ◽

Drug Resistant ◽

Tuberculosis Complex ◽

Innovative Drug ◽

Recent Developments ◽

Resistant Strains ◽

Delivery Strategies ◽

Drug Resistant Strains ◽

Novel Drug

Tuberculosis (TB) is a contagious infectious illness caused by species having a place with the Mycobacterium tuberculosis complex. The clinical management of tuberculosis still remains a difficult task. Treatment of TB with anti-tubercular drugs becomes the only option available. Hence, the goals of treatment are ensure cure without relapse, prevent death, impede transmission, and prevent emergence of drug resistant strains. This review describes the latest developments and innovative drug delivery strategies for treatment of TB in order to improve the therapeutic efficacy and reduce toxic effect of anti-tubercular agents and enhance patient compliance with concomitant decrease in drug interaction. Among different novel drug delivery systems Niosomes, Liposomes, Dendrimers, Cyclodextrins, Microencapsulation, Alginates and Hydrogels have been described as new drug delivery strategies of anti-tubercular agents.

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Novel Drug Delivery Strategies for the Treatment of Onychomycosis

Pharmaceutical Nanotechnology ◽

10.2174/2211738507666190228104031 ◽

2019 ◽

Vol 7 (1) ◽

pp. 24-38 ◽

Cited By ~ 6

Author(s):

Rupinder K. Dhamoon ◽

Harvinder Popli ◽

Madhu Gupta

Keyword(s):

Drug Delivery ◽

Topical Therapy ◽

Treatment Options ◽

Polymeric Films ◽

Prolonged Treatment ◽

The Novel ◽

Delivery Strategies ◽

Novel Drug ◽

Physical And Chemical ◽

Made In

Onychomycosis accounts for 50% of all nail disease cases and is commonly caused by dermatophytes. It was primarily considered a cosmetic problem but has been garnering attention lately due to its persistent nature and difficult treatment with relapses. With prolonged treatment duration and high cost involved in treating onychomycosis, several attempts have been made in overcoming the rigid nail barrier. The conventional treatment of onychomycosis involves oral and topical therapy. The oral antifungal agents though quite effective, are hepato-toxic and cause drug-drug interactions. Topical therapy is more patient compliant being devoid of such adverse effects but it suffers from another setback of improper nail penetration. Amorolfine and ciclopirox nail lacquers are popular market products. Since decades, efforts have been made to enhance topical delivery for efficiently treating onychomycosis. Mechanical, physical and chemical methods have been employed. Despite all the attempts made, the nail delivery issues are far from being solved. Recently, the focus has shifted to novel drug delivery systems like nanoparticles, microemulsions, polymeric films and nail lacquers for enhanced drug permeation and localized therapy. The research around the world is exploring their potential as effective treatment options. This review intends to further explore the novel delivery strategies to treat a persistent fungal infection like onychomycosis.

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