Study of Trace Elements Selenium, Copper, Zinc and Manganese Level in Polycystic Ovary Syndrome (PCOS)

Introduction: Polycystic ovary syndrome (PCOS) is one of the most commonly recognized endocrinopathies in women. The literature lacks clear data that allow any meaningful conclusions to be drawn about the influence of trace elements in erythrocytes on the biochemical parameters of PCOS. Materials and methods: This study was conducted among 47 women meeting the Rotterdam criteria for the diagnosis of polycystic ovary syndrome. The research groups included women with PCOS with different BMI values (body mass index): obese women with PCOS (PCOS with BMI ≥ 30, mean BMI index 35.4 ± 4.4 kg/m2), nonobese PCOS women (PCOS with BMI < 30, mean BMI index 25.2 ± 2.8 kg/m2), and healthy control group (CG) with a mean BMI of 23.57 ± 0.9 kg/m2. The contents of trace elements in erythrocytes were determined with an inductively coupled plasma atomic emission spectrometer. Results: The only trace element showing significant differences in concentration between the studied groups was nickel (Ni). The level of nickel in the obese women with PCOS (BMI ≥ 30) was significantly higher than in nonobese women (BMI < 30). The content of other trace elements in erythrocytes did not differ significantly between the studied groups. Several significant correlations were found within each of the studied PCOS groups: in the group of obese women, the content of zinc (Zn) in erythrocytes positively correlated with prolactin, the content of magnesium (Mg) positively correlated with testosterone, and the content of manganese (Mn) negatively correlated with thyroid-stimulating hormone. In the group of nonobese women, Zn content correlated positively with testosterone, Ni with luteinizing hormone (LH) and estradiol, and Mg negatively correlated with estradiol. Conclusions: The relationship between the level of trace elements and the level of hormones suggests that, in obese women with PCOS, nickel may play a role in inhibiting the processes of folliculogenesis and ovulation. Research on trace elements and their relationship to ovulatory cycles and the development of PCOS may contribute to reducing the consequences of PCOS and, therefore, should be extended.

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Assessment of the levels of some trace elements in polycystic ovary syndrome and the possible association With insulin resistance.

International Journal of Pharma and Bio Sciences ◽

10.22376/ijpbs.2017.8.1.b143-151 ◽

2017 ◽

Vol 8 (1) ◽

Author(s):

MILAL M. AL-JEB ORRY

Keyword(s):

Insulin Resistance ◽

Trace Elements ◽

Polycystic Ovary Syndrome ◽

Polycystic Ovary ◽

Ovary Syndrome

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Serum trace elements and heavy metals in polycystic ovary syndrome

Human & Experimental Toxicology ◽

10.1177/0960327111424299 ◽

2011 ◽

Vol 31 (5) ◽

pp. 452-456 ◽

Cited By ~ 28

Author(s):

Z Kurdoglu ◽

M Kurdoglu ◽

H Demir ◽

HG Sahin

Keyword(s):

Heavy Metals ◽

Trace Elements ◽

Polycystic Ovary Syndrome ◽

Polycystic Ovary ◽

Serum Levels ◽

Healthy Controls ◽

Ovary Syndrome ◽

Essential Trace Elements ◽

Serum Trace Elements ◽

Healthy Participants

Objective: We aimed to investigate the serum levels of essential trace elements copper (Cu), zinc (Zn), manganese (Mn), magnesium (Mg) and heavy metals cadmium (Cd), cobalt (Co) and lead (Pb) in the patients with polycystic ovary syndrome (PCOS). Methods: A total of 65 (35 patients with PCOS and 30 healthy controls) women were included in the study. Serum Cu, Zn, Mn, Pb, Mg, Co and Cd levels were analyzed using atomic absorption spectrophotometric method. Results: Serum Cu and Zn levels were significantly higher, but Mn and Pb levels were lower in patients with PCOS compared with the healthy participants ( p < 0.01). There was no difference between patients with PCOS and the controls with respect to the serum levels of Mg, Co and Cd. Conclusions: This is the first study investigating serum Cu, Zn, Mn, Pb, Co, Mg and Cd levels in the patients with PCOS. The serum levels of trace elements and heavy metals might change in patients with PCOS. The findings in this study should be investigated with further trials in order to obtain new insights into PCOS.

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