scholarly journals Intra Vaginal Drug Delivery System (Novel Drug Delivery System)

2020 ◽  
Vol 7 (6) ◽  
pp. 234-241
Author(s):  
Ankit Kumar ◽  
Sanjeev Kumar
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Trichomonas Vaginalis ◽  
Bacterial Infections ◽  
Dosage Form ◽  
Female Reproductive Tract ◽  
Gardnerella Vaginalis ◽  
Vaginal Mucosa ◽  
Novel Drug

In case of intra-vaginal route of drug administration the dosage form is applied vaginally for the convenient release of the dosage form and for better therapeutic action of the medicament, it is usually used in HIV patients. many conditions that affect the  female reproductive tract, such as , sexually transmitted diseases, fungal & bacterial infections,  cancer and various pathogens such as virus (human immunodeficiency virus, HIV), bacteria (Gardnerella vaginalis), fungi (Candida spp.) or parasites (Trichomonas vaginalis). Systemically active drugs (contraceptive steroids) as well as locally active drugs (metronidazole Zidovudine, Lamivudine) can be effectively delivered for an extended period of time by the help of intra-vaginal  controlled release system. Continuous infusion of drugs through vaginal mucosa results in the reduced possibilities of Hepatic- gastrointestinal first-pass metabolism, gastric impatience of drugs and vacillation of dosing interval. Current study focus on the, use of various polymers which are used in hydrogels, these polymers provide bioadhesive property to the vaginal formulations, so that the vaginal formulation remains on vaginal tissues for 3- 4 days. Currently available vaginal dosage forms have several limitations, such as leakage and messiness necessitating the need to develop novel drug delivery systems.

scholarly journals REVIEW ON FORMULATION AND EVALUATION OF SOLID LIPID NANOPARTICLES FOR VAGINAL APPLICATION

2022 ◽  
pp. 1-8
Author(s):  
PALLERLA PRIYANKA ◽  
M. SRI REKHA ◽  
A. SEETHA DEVI
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Bacterial Infections ◽  
Reproductive Tract ◽  
Female Reproductive Tract ◽  
Low Permeability ◽  
Self Medication ◽  
Vaginal Drug Delivery ◽  
Short Period

Vaginal drug administration can improve prophylaxis and treatment of many conditions affecting the female reproductive tract, which includes fungal and bacterial infections, sexually transmitted diseases and cancer also. This is the best route for the administration of proteins, peptides, and also other therapeutic drugs like macro-molecules. For the administration of drugs like contraceptives, steroids, metronidazole, anti-retroviral, vaginal drug delivery is the most preferable route. However, achieving sufficient drug concentration in the vagina can be challenging because of its low permeability. The benefits of the vaginal drug delivery system are it increases the bioavailability, least systemic side effects; easiness of use and self-medication is possible. However vaginal drug delivery system is considered as a less effective route because of the unfortunate absorption of drugs across the vaginal epithelium. The traditional commercial preparations, such as creams, foams, gels, irrigations and tablets, are known to reside in the vaginal cavity for a relatively short period of time owing to the self-cleaning action of the vaginal tract and often require multiple daily doses to ensure the desired therapeutic effect. With the rapidly developing field of nanotechnology, the use of specifically designed carrier systems such as Nanoparticle-based drug delivery has been proven an excellent choice for vaginal application to overcome the challenges associated with the low permeability.

Niosomes: The Current and Future perspectives in Drug Delivery System

2021 ◽  
pp. 3961-3966
Author(s):  
Bhupendra Singh ◽  
Pooja Sharma ◽  
Sujit Bose ◽  
Jyoti Thakur ◽  
Geetanjali Saini ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Dosage Form ◽  
Ionic Surfactants ◽  
Future Perspectives ◽  
Conventional Drug ◽  
Dosing Frequency ◽  
Novel Drug Delivery System ◽  
Novel Drug

There are many problems with the conventional dosage form of various drugs and one of them is dosing frequency in which patients have to take the drug again and again throughout the day which is very difficult mainly for the elder patient. So, to overcome this problem the approach of a novel drug delivery system (NDDS) is used to replace the conventional drug delivery system. NDDS mainly deals with sustained release of drugs which is effective to reduce the dosing frequency. Niosome is one of the best approaches of a novel drug delivery system, in which the drug in solution form is enclosed in vesicle which is made up of non-ionic surfactants. In the case of liposome which is another part of NDDS vesicles is made up of phospholipids. Niosome formulation is a powerful tool to resolve the issue of insolubility and the low bioavailability of drugs. This paper overviews the various methods of preparation of Niosome along with its pharmaceutical applications.

scholarly journals Topical Dosage Form & Delivery System for Pigmentation Control: A Review

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 1341-1349
Author(s):  
Yap Vi Lien ◽  
Mogana R ◽  
Sasikala Chinnappan ◽  
Ashok Kumar Janakiraman ◽  
Tan Lee Fang
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Dosage Form ◽  
Skin Penetration ◽  
Dosage Forms ◽  
Brown Pigment ◽  
Tyrosinase Enzyme ◽  
Novel Drug ◽  
Conventional Dosage

Hyperpigmentation is one of the most commonly seen skin disorders which is not a concerning health issues but it may affect the psychological aspect of a person. Hyperpigmentation is caused by the presence of excess melanin, which is the brown pigment of the skin. Products that aimed to reduce the pigmentations act by inhibiting the tyrosinase enzyme, which is the rate-limiting enzyme in the synthesis of melanin. There are many products that are currently available in the market that aims to reduce pigmentation of the skin. These products are conventionally formulated into different dosage forms such as cream, lotion and emulgel, which gains popularity due to its convenience on application. However, due to the drawbacks that these dosage forms possess such as poor stability and absorption, new formulations are presented which incorporate novel drug delivery system into the conventional dosage forms. These novel drug delivery systems are, inter alia, liposome, niosomes and microsphere. They carry benefits of controlled drug delivery, enhanced skin penetration and reduce drug toxicity as compared to the conventional dosage form, which resulted in the increase in marketed product diving into this pathway. This present article will discuss the various dosage forms, drug delivery system, its advantages, disadvantages and marketed product for pigmentation control.

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