The effects of naloxone and timolol on plasma catecholamine levels during short-term dynamic exercise

1987 ◽  
Vol 47 (8) ◽  
pp. 847-851 ◽  
Author(s):  
L. Gullestad ◽  
L. Øystein Dolva ◽  
S. E. Kjeldsen ◽  
I. Eide ◽  
J. Kjekshus
Keyword(s):  
Dynamic Exercise ◽  
Plasma Catecholamine ◽  
Short Term ◽  
Catecholamine Levels

Platelet Catecholamine Concentrations after Short-Term Stress in Normal Subjects

1994 ◽  
Vol 86 (1) ◽  
pp. 35-41 ◽  
Author(s):  
E. Carstensen ◽  
John S. Yudkin
Keyword(s):  
Psychological Stress ◽  
Plasma Noradrenaline ◽  
Plasma Catecholamine ◽  
Short Term ◽  
Bicycle Ergometry ◽  
Plasma Adrenaline ◽  
Before And After ◽  
Significant Change ◽  
Plasma Catecholamine Concentrations ◽  
Catecholamine Levels

1. Four studies were designed to test the hypothesis that platelet catecholamine levels may provide a stable index of circulating plasma catecholamine concentrations, and that these are unaffected by acute elevations of plasma levels with physical and psychological stress. 2. To assess the biological variability within individuals, ten subjects were sampled on five occasions over 8–30 h. The intra-individual coefficients of variation for plasma and platelet noradrenaline levels were 193 +10% and 9.5 +4.2%, respectively, and for plasma and platelet adrenaline levels 48.3 +22% and 25.3 +8.4%, respectively. 3. Three other studies investigating the response to physical and psychological stress were performed. In the first study, plasma and platelet catecholamine levels were studied in 12 healthy subjects before and after bicycle ergometry. Plasma catecholamine concentrations increased [noradrenaline by +346 + 323% (P = 0.002) and adrenaline by +314 + 352% (P -0.003)], whereas platelet concentrations showed little change [noradrenaline +4+18% (P = 0.94) and adrenaline +38+ 116% (P = 0.67)]. 4. In the study, catecholamine concentrations were measured in eight subjects after hand immersion in iced water. Plasma noradrenaline concentrations increased significantly (+58 +19%, P = 0.001), but no significant change was found in plasma adrenaline concentrations (+8+44%, P = 0.48). Platelet catecholamine concentrations showed no significant change (noradrenaline +15 +15%, P = 0.052, and adrenaline 19 +82%, P = 0.84). 5. In the third study, catecholamine concentrations were measured in 22 medical students before and after their end-of-year examination. There was no significant change in plasma noradrenaline or adrenaline concentrations (+20 +39%, P = 0.08, and −2 +33%, P = 0.36, respectively) nor in platelet concentrations (noradrenaline +6+19%, P = 0.15, and adrenaline +34 +72, P = 0.65). 6. In 53 subjects sampled between 08.00 and 12.00 hours, plasma and platelet noradrenaline concentrations were significantly correlated (r, = 0.47, P <0.001), but the relationship between plasma and platelet adrenaline concentrations in these subjects did not achieve significance (rs = 0.17, P <0.23). 7. In conclusion, platelet catecholamine concentrations seem to be unaffected by acute short-term stress and may provide a reliable indicator of chronic sympatho-adrenomedullary arousal.

Ethanol intake, plasma catecholamine levels, and ST-segment changes without myocardial injury in rats with short-term ethanol consumption

1995 ◽  
Vol 28 (4) ◽  
pp. 307-312 ◽  
Author(s):  
Panayotis Fantidis ◽  
Maria Jesus Del Cerro ◽  
Isabel Martínez ◽  
Gabriel Rubio ◽  
Antonio Ruiz Villaespesa ◽  
...  
Keyword(s):  
Myocardial Injury ◽  
Ethanol Consumption ◽  
Ethanol Intake ◽  
Plasma Catecholamine ◽  
Short Term ◽  
St Segment ◽  
Catecholamine Levels

Sorafenib in the treatment of metastatic paraganglioma: A case report.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e13523-e13523
Author(s):  
Meral Gunaldi ◽  
Ismail Oguz Kara ◽  
Cigdem Usul Afsar ◽  
Berna Bozkurt Duman
Keyword(s):  
Treatment Options ◽  
Complete Response ◽  
Plasma Catecholamine ◽  
Short Term ◽  
Metastatic Lesions ◽  
Pet Ct ◽  
History Of ◽  
Catecholamine Levels ◽  
Therapy Treatment

e13523 Background: Paragangliomas (extra-adrenal pheochromocytomas) are rare chromaffin cell tumors that can often be cured by resection. Excess release of catecholamines is characteristic for paragangliomas. Paragangliomas are mostly benign if diagnosed and treated early. Overall 0–36% of paraganglioma patients develop metastatic disease, depending on the type of tumor. Methods: We present a case of a 43-year-old woman who admitted to our department with a history of episodic headaches, diaphoresis and weakness. Hypertension and tachycardia were diagnosed. She had elevated plasma catecholamine levels and a right paraaortic mass (9x9.5cm) was visualized on CT. The mass was excised and the diagnosis of paraganglioma was confirmed. In postoperative follow-up the patient's blood pressure and catecholamine levels were normalized. After twenty months follow up, local recurrence and metastases were detected in thorax, abdomen, and skeletal system. Plasma catecholamine levels were high. Results: Chemotherapy with CVD (adriamycine (7mg/m2), dacarbazine (400mg/m2), cyclophosphamide (500mg/m2), vincristine (1.4mg/m2) on day 1 and 2, repeated every 21 days; were administered and no improvement was observed in PET-CT following a treatment of three cycles. Sorafenib (800mg/m2/day) was applied for three-months. Finally the patient’s plasma catecholamine levels and metastatic lesions regressed. Conclusions: Treatment options of metastatic paragangliomas (MP) are removal by excision or ablation, chemotherapy, or targeted pharmaceuticals. Benefits of CVD chemotherapy for MP appears to be short-term and do not include an increase in patient survival. As targeted therapy, treatment of MP with everolimus or imatinib were attempted with no significant benefit, and thus are not recommended. However partial response was reported with Sunitinib some cases. We used sorafenib as another multiple TKI and detected complete response. So far, sorafenib has not been applied in the treatment of MP in literature. Sorafenib can be preferred in the treatment of MP. Therefore, more comprehensive clinical trials are needed.

Plasma Catecholamine Levels and Vascular Response in Deoxycorticosterone Acetate Hypertension of Rats

1980 ◽  
Vol 59 (s6) ◽  
pp. 315s-317s ◽  
Author(s):  
W. Rascher ◽  
R. Dietz ◽  
A. Schomig ◽  
J. Weber ◽  
F. Gross
Keyword(s):  
Hind Limb ◽  
Vascular Tone ◽  
Plasma Concentrations ◽  
Plasma Catecholamine ◽  
Vascular Response ◽  
Deoxycorticosterone Acetate ◽  
Pronounced Increase ◽  
Basal Plasma ◽  
Noradrenaline And Adrenaline ◽  
Catecholamine Levels

1. In rats with deoxycorticosterone acetate (DOCA) hypertension basal plasma concentrations of noradrenaline and adrenaline correspond to those of sham-treated controls. 2. In DOCA-treated rats frusemide caused a more pronounced increase in plasma noradrenaline than in control rats. This difference was not observed for adrenaline. 3. In the isolated perfused hind-limb preparation the sensitivity to noradrenaline was already enhanced before blood pressure was elevated. 4. These results suggest that the adrenergic vascular tone is increased in DOCA hypertension in rats.

Administration of docosahexaenoic acid influences behavior and plasma catecholamine levels at times of psychological stress

Lipids ◽  
1999 ◽  
Vol 34 (S1) ◽  
pp. S33-S37 ◽  
Author(s):  
Tomohito Hamazaki ◽  
Shigeki Sawazaki ◽  
Tetsuro Nagasawa ◽  
Yoko Nagao ◽  
Yuko Kanagawa ◽  
...  
Keyword(s):  
Docosahexaenoic Acid ◽  
Psychological Stress ◽  
Plasma Catecholamine ◽  
Catecholamine Levels

Rhinitis during pregnancy and rhinitis medicamentosa

1992 ◽  
Vol 107 (6_part_2) ◽  
pp. 845-849 ◽  
Author(s):  
Mary D. Lekas
Keyword(s):  
Intranasal Corticosteroid ◽  
Short Term ◽  
Vasomotor Rhinitis ◽  
Nasal Sprays ◽  
Nasal Steroids ◽  
Rebound Phenomenon ◽  
Nasal Blood Vessels ◽  
Rhinitis Medicamentosa ◽  
Corticosteroid Injections ◽  
Catecholamine Levels

Vasomotor rhinitis is a nonspecific disorder that is caused neither by infection nor allergy but rather by an imbalance of the autonomic nervous system with a preponderant action of parasympathetic fibers on nasal blood vessels. Rhinitis during pregnancy appears to result from the increased production of estrogen; increased estrogen levels caused by treatment, puberty, or liver disease may also cause rhinitis. Nasal saline mist, antihistamines, and topical corticosteroids are recommended; intranasal corticosteroid injections are also useful but must be administered under expert care. Rhinitis medicamentosa results from overuse of topical vasoconstrictors, which produce a rebound phenomenon. Rebound can also result from numerous medications, including antihypertensive preparations that reduce catecholamine levels, antidepressants, antipsychotics, and tranquilizers. Management of rhinitis medicamentosa consists in limiting the use of vasoconstrictors to no more than 3 days and giving the patient saline nasal sprays, daytime oral vasoconstrictors, and nocturnal antihistamines. Corticosteroids, preferably topical nasal steroids rather than even a short-term course of systemic administration, should also be used.

Activation of central GABAA receptors suppresses the alteration of plasma catecholamine levels induced by neostigmine or histamine in rats

Life Sciences ◽  
1994 ◽  
Vol 55 (21) ◽  
pp. PL409-PL413 ◽  
Author(s):  
Katsunori Nonogaki ◽  
Kotomi Mizuno ◽  
Nobuo Sakamoto ◽  
Akihisa Iguchi
Keyword(s):  
Gabaa Receptors ◽  
Plasma Catecholamine ◽  
Catecholamine Levels

THE EFFECTS OF ACCLIMATION TEMPERATURE ON THE DYNAMICS OF CATECHOLAMINE RELEASE DURING ACUTE HYPOXIA IN THE RAINBOW TROUT ONCORHYNCHUS MYKISS

1994 ◽  
Vol 186 (1) ◽  
pp. 289-307 ◽  
Author(s):  
S. Perry ◽  
S. Reid
Keyword(s):  
Rainbow Trout ◽  
Acute Hypoxia ◽  
Catecholamine Release ◽  
Acclimation Temperature ◽  
Plasma Catecholamine ◽  
Blood Oxygen ◽  
Rainbow Trout Oncorhynchus Mykiss ◽  
Arterial Blood ◽  
The Difference ◽  
Catecholamine Levels

The response of cannulated rainbow trout (Oncorhynchus mykiss) to acute hypoxia was studied in fish acclimated to two temperatures (5 and 15 °C). Blood/water respiratory variables and plasma catecholamine levels were measured before and 15 min after exposure to hypoxic water varying between 4.0 and 10.7 kPa (30–80 mmHg) oxygen partial pressure (PwO2). Arterial blood PO2 (PaO2) and oxygen content (CaO2) fell during hypoxia in a similar manner at both temperatures, although the changes in CaO2 were often more pronounced in the fish acclimated to 15 °C. Regardless of acclimation temperature, plasma catecholamine levels were consistently elevated at PwO2 values below 8.0 kPa (60 mmHg); the largest increases in plasma catecholamine levels occurred below PwO2=5.3 kPa (40 mmHg). Adrenaline was the predominant catecholamine released into the circulation. Adrenaline was released at PwO2 values of 8.0 kPa or below, whereas noradrenaline was released at PwO2 values of 6.7 kPa or below. The construction of in vivo oxygen dissociation curves demonstrated an obvious effect of acclimation temperature on haemoglobin (Hb) oxygen-affinity; the P50 values at 15 °C and 5 °C were 3.6 kPa (26.7 mmHg) and 1.9 kPa (14.0 mmHg), respectively. At 15 °C, catecholamines were released into the circulation abruptly at a PaO2 threshold of 4.6 kPa (34.5 mmHg) while at 5 °C the catecholamine release threshold was lowered to 3.3 kPa (24.5 mmHg). The difference in the PaO2 catecholamine release thresholds was roughly equivalent to the difference in the P50 values at the two distinct temperatures. Catecholamine release thresholds, calculated on the basis of arterial blood oxygen-saturation (expressed as CaO2/[Hb]), were similar at both temperatures and were approximately equal to 53–55 % Hb O2-saturation. The results support the contention that the lowering of blood oxygen content/saturation rather than PO2 per se is the proximate stimulus/signal causing catecholamine release in rainbow trout during acute hypoxia.

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