Platelet Catecholamine Concentrations after Short-Term Stress in Normal Subjects

1994 ◽  
Vol 86 (1) ◽  
pp. 35-41 ◽  
Author(s):  
E. Carstensen ◽  
John S. Yudkin
Keyword(s):  
Psychological Stress ◽  
Plasma Noradrenaline ◽  
Plasma Catecholamine ◽  
Short Term ◽  
Bicycle Ergometry ◽  
Plasma Adrenaline ◽  
Before And After ◽  
Significant Change ◽  
Plasma Catecholamine Concentrations ◽  
Catecholamine Levels

1. Four studies were designed to test the hypothesis that platelet catecholamine levels may provide a stable index of circulating plasma catecholamine concentrations, and that these are unaffected by acute elevations of plasma levels with physical and psychological stress. 2. To assess the biological variability within individuals, ten subjects were sampled on five occasions over 8–30 h. The intra-individual coefficients of variation for plasma and platelet noradrenaline levels were 193 +10% and 9.5 +4.2%, respectively, and for plasma and platelet adrenaline levels 48.3 +22% and 25.3 +8.4%, respectively. 3. Three other studies investigating the response to physical and psychological stress were performed. In the first study, plasma and platelet catecholamine levels were studied in 12 healthy subjects before and after bicycle ergometry. Plasma catecholamine concentrations increased [noradrenaline by +346 + 323% (P = 0.002) and adrenaline by +314 + 352% (P -0.003)], whereas platelet concentrations showed little change [noradrenaline +4+18% (P = 0.94) and adrenaline +38+ 116% (P = 0.67)]. 4. In the study, catecholamine concentrations were measured in eight subjects after hand immersion in iced water. Plasma noradrenaline concentrations increased significantly (+58 +19%, P = 0.001), but no significant change was found in plasma adrenaline concentrations (+8+44%, P = 0.48). Platelet catecholamine concentrations showed no significant change (noradrenaline +15 +15%, P = 0.052, and adrenaline 19 +82%, P = 0.84). 5. In the third study, catecholamine concentrations were measured in 22 medical students before and after their end-of-year examination. There was no significant change in plasma noradrenaline or adrenaline concentrations (+20 +39%, P = 0.08, and −2 +33%, P = 0.36, respectively) nor in platelet concentrations (noradrenaline +6+19%, P = 0.15, and adrenaline +34 +72, P = 0.65). 6. In 53 subjects sampled between 08.00 and 12.00 hours, plasma and platelet noradrenaline concentrations were significantly correlated (r, = 0.47, P <0.001), but the relationship between plasma and platelet adrenaline concentrations in these subjects did not achieve significance (rs = 0.17, P <0.23). 7. In conclusion, platelet catecholamine concentrations seem to be unaffected by acute short-term stress and may provide a reliable indicator of chronic sympatho-adrenomedullary arousal.

Administration of docosahexaenoic acid influences behavior and plasma catecholamine levels at times of psychological stress

Lipids ◽  
1999 ◽  
Vol 34 (S1) ◽  
pp. S33-S37 ◽  
Author(s):  
Tomohito Hamazaki ◽  
Shigeki Sawazaki ◽  
Tetsuro Nagasawa ◽  
Yoko Nagao ◽  
Yuko Kanagawa ◽  
...  
Keyword(s):  
Docosahexaenoic Acid ◽  
Psychological Stress ◽  
Plasma Catecholamine ◽  
Catecholamine Levels

Aerobic training improves exercise-induced lipolysis in SCAT and lipid utilization in overweight men

2003 ◽  
Vol 285 (5) ◽  
pp. E984-E990 ◽  
Author(s):  
I. de Glisezinski ◽  
C. Moro ◽  
F. Pillard ◽  
F. Marion-Latard ◽  
I. Harant ◽  
...  
Keyword(s):  
Lipid Oxidation ◽  
Nonesterified Fatty Acid ◽  
Plasma Catecholamine ◽  
Lipid Mobilization ◽  
Before And After ◽  
Exercise Induced ◽  
Plasma Catecholamine Concentrations ◽  
Subcutaneous Adipose ◽  
Overweight Subjects ◽  
Moderate Exercise Training

The aim of this study was to investigate whether endurance training improves lipid mobilization and oxidation in overweight subjects. Eleven young men (25.6 ± 1.4 yr and body mass index 27.7 ± 0.2) performed a 4-mo training program consisting of practicing aerobic exercise 5 days/wk. Before and after the training period, lipid oxidation was explored during a 60-min exercise at 50% of peak O2 consumption by use of indirect calorimetry. Lipid mobilization and antilipolytic α2-adrenoceptor effect were also studied using the microdialysis method in abdominal subcutaneous adipose tissue (SCAT). After training, plasma nonesterified fatty acid (NEFA) levels, at rest and during exercise, were significantly lower than before ( P < 0.001). Lipolysis in SCAT was significantly higher after than before training. An antilipolytic α2-adrenoceptor effect in SCAT was underlined during exercise before training and disappeared after. The respiratory exchange ratio was lower after training, i.e., the percentage of lipid oxidation was higher only at rest. The amount of lipid oxidized was higher after training, at rest, and during exercise. Although exercise power was higher after training, the relative intensity was equivalent, as suggested by a similar increase in plasma catecholamine concentrations before and after training. In conclusion, 4-mo training in overweight men improved lipid mobilization through a decrease of antilipolytic α2-adrenoceptor effect in SCAT and lipid oxidation during moderate exercise. Training induced a decrease of blood NEFA, predicting better prevention of obesity.

Effect of Psychic Stimulation on Plasma Catecholamine Concentrations and Nasal Patency in Patients with Nasal Allergy

1994 ◽  
Vol 103 (5) ◽  
pp. 375-382 ◽  
Author(s):  
Akiyoshi Konno ◽  
Nobuhisa Terada ◽  
Minoru Nomoto
Keyword(s):  
Nasal Mucosa ◽  
Mental Arithmetic ◽  
Plasma Norepinephrine ◽  
Plasma Catecholamine ◽  
Nasal Allergy ◽  
Nasal Patency ◽  
Significant Difference ◽  
Plasma Catecholamine Concentrations ◽  
Normal Controls ◽  
Catecholamine Levels

To compare the degree of sympathoadrenal and nasal vascular response to psychic stimulation between patients with nasal allergy and normal controls, we measured the changes in plasma norepinephrine and epinephrine concentrations and nasal patency elicited by cannulation into the forearm vein and mental arithmetic in 28 patients with nasal allergy and age- and sex-matched normal controls. Ten of the 28 allergy patients had markedly swollen, pale, edematous nasal mucosa and served as a subgroup of nasal allergy patients. Plasma catecholamine levels increased significantly, with a synchronous increase of nasal patency, during stimulation. Among the three groups, no statistical differences were observed in plasma catecholamine levels either at rest or during stimulation. There was no significant difference in extent of increase of nasal patency induced by stimulation in the total group of subjects with nasal allergy compared with normal controls. However, it was significantly smaller in a subgroup of nasal allergy patients having markedly pale, edematous swelling of the nasal mucosa.

Changes in sympathoadrenal response to standing in humans after spaceflight

1995 ◽  
Vol 79 (2) ◽  
pp. 428-433 ◽  
Author(s):  
P. A. Whitson ◽  
J. B. Charles ◽  
W. J. Williams ◽  
N. M. Cintron
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Stroke Volume ◽  
Space Shuttle ◽  
Cardiovascular Responses ◽  
Plasma Norepinephrine ◽  
Plasma Catecholamine ◽  
Blood Samples ◽  
Before And After ◽  
Catecholamine Levels

Plasma catecholamine levels and cardiovascular responses to standing were determined in astronauts before and after several Space Shuttle missions. Blood pressure, heart rate, and cardiac output were measured and blood samples for catecholamine analyses were drawn at the end of the supine and standing periods. Supine plasma norepinephrine and epinephrine concentrations increased 34 and 65%, respectively, on landing day compared with before flight. Standing on landing day resulted in a 65 and 91% increase in plasma norepinephrine and epinephrine, respectively. Supine and standing norepinephrine levels remained elevated 3 days after landing while epinephrine levels returned to preflight levels. On landing day, supine heart rate and systolic blood pressure increased 18 and 8.9%, respectively, and standing heart rate and diastolic blood pressure were elevated by 38 and 19%, respectively. On standing, stroke volume was decreased by 26% on landing day compared with before flight. Collectively, these data indicate that the decreased orthostatic function after spaceflight results largely from the decreased stroke volume. Possible mechanisms contributing to this condition are discussed.

The effects of naloxone and timolol on plasma catecholamine levels during short-term dynamic exercise

1987 ◽  
Vol 47 (8) ◽  
pp. 847-851 ◽  
Author(s):  
L. Gullestad ◽  
L. Øystein Dolva ◽  
S. E. Kjeldsen ◽  
I. Eide ◽  
J. Kjekshus
Keyword(s):  
Dynamic Exercise ◽  
Plasma Catecholamine ◽  
Short Term ◽  
Catecholamine Levels

Alterations in β-adrenergic sensitivity and platelet α2-adrenoceptors in obese women: effect of exercise and caloric restriction

1990 ◽  
Vol 78 (1) ◽  
pp. 81-87 ◽  
Author(s):  
Ivan Berlin ◽  
Michel Berlan ◽  
Brigitte Crespo-Laumonnier ◽  
Catherine Landault ◽  
Christine Payan ◽  
...  
Keyword(s):  
Caloric Restriction ◽  
Plasma Catecholamines ◽  
Bed Rest ◽  
Plasma Noradrenaline ◽  
Obese Women ◽  
Apparent Dissociation Constant ◽  
Plasma Adrenaline ◽  
Α2 Adrenoceptors ◽  
Α2 Adrenoceptor ◽  
Before And After

1. Peripheral adrenergic responses were studied in eight obese women before and after 15 days of caloric restriction (2500 kJ/day) and in eight sex- and age-matched lean controls. 2. β-Adrenergic sensitivity (defined as the dose of isoprenaline required to increase resting heart rate by 25 beats/min) was evaluated before and after the diet. Density and affinity (determined as the apparent dissociation constant) of platelet α2-adrenergic receptors, and plasma adrenaline and noradrenaline levels, were measured after overnight bed-rest and after 9 min of standardized exercise performed before and after the low caloric diet. 3. Before the diet basal antecubital venous plasma noradrenaline concentrations were lower in obese women when compared with lean women (0.94 ± 0.06 vs 1.27 ± 0.17 nmol/l, P < 0.02). Isoprenaline sensitivity did not differ between lean and obese women. 4. At rest, platelet α2-adrenoceptor density was lower in overweight than in lean women (129 ± 21 vs 168 ± 16 fmol/mg of protein, P < 0.02). Exercise significantly increased platelet α2-adrenoceptor density and decreased affinity in lean women. This decrease correlated with the rise in plasma noradrenaline. 5. In obese women exercise did not modify platelet α2-adrenoceptor density or affinity, despite a significant increase in plasma catecholamines. However, the increase in plasma noradrenaline during exercise was lower in obese women. 6. The low caloric diet produced a β-adrenergic supersensitivity. 7. We conclude that (a) obesity does not alter β-adrenergic sensitivity; (b) 15 days of caloric restriction produces a β-adrenergic supersensitive state; (c) obese women show an inability to desensitize platelet α2-adrenoceptors in response to exercise.

The Distribution of Catecholamines between Platelets and Plasma in Normal Human Subjects

1985 ◽  
Vol 69 (1) ◽  
pp. 1-6 ◽  
Author(s):  
C. C. T. Smith ◽  
L. D. Curtis ◽  
A. P. Delamothe ◽  
B. N. C. Prichard ◽  
D. J. Betteridge
Keyword(s):  
High Performance ◽  
Human Subjects ◽  
Normal Subjects ◽  
Plasma Noradrenaline ◽  
Plasma Catecholamine ◽  
Noradrenaline Content ◽  
Platelet Factor ◽  
Normal Human ◽  
Catecholamine Levels

1. We have used high-performance liquid chromatography with electrochemical detection to measure content of adrenaline and noradrenaline in platelets in 13 normal subjects at rest. 2. Subjects were exercised to raise plasma catecholamine levels and promote the platelet release reaction. 3. There was a significant positive correlation between plasma noradrenaline concentrations and platelet noradrenaline content. 4. Platelet/plasma concentration ratios were 1855 for noradrenaline and 268 for adrenaline at rest and 473 and 152 respectively after exercise. 5. Plasma noradrenaline levels positively correlated with age. 6. Determination of platelet factors released to the plasma showed increases of β-thromboglobulin and platelet factor 4 with exercise, whereas thromboxane B2 remained unchanged. No change in platelet catecholamine levels occurred with exercise and no correlations were observed between platelet catecholamines and released platelet factors. 7. These data suggest that plasma catecholamine levels influence platelet content and that noradrenaline and adrenaline are concentrated in platelets.

scholarly journals The Effects of Gallamine and a Mixture of Pancuronium and Alcuronium on the Pressor and Plasma Catecholamine Responses to Tracheal Intubation

1984 ◽  
Vol 12 (1) ◽  
pp. 22-26 ◽  
Author(s):  
Mary F. Cummings ◽  
W. J. Russell ◽  
D. B. Frewin ◽  
Wendy A. Miller
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Mean Arterial Pressure ◽  
Tracheal Intubation ◽  
Arterial Pressure ◽  
Plasma Noradrenaline ◽  
Plasma Catecholamine ◽  
Plasma Adrenaline ◽  
Noradrenaline Concentration ◽  
Noradrenaline And Adrenaline

Tracheal intubation can be accompanied by significant increases in arterial pressure, heart rate and the plasma levels of noradrenaline and adrenaline. The drugs used at induction can enhance or attenuate these responses. In nine patients who had received gallamine, intubation was associated with a 45% rise in mean arterial pressure, a twofold rise in plasma adrenaline and a 49% rise in plasma noradrenaline concentration. When a mixture of pancuronium and alcuronium (in a ratio of 4:10 by weight) was used in ten patients, blood pressure fell 24% after induction and rose 49% after intubation. A 24% rise in plasma noradrenaline in response to intubation was also observed. Compared with pancuronium alone, the use of the mixture attentuates the rise in blood pressure and noradrenaline concentration associated with intubation but does not abolish them. In addition, the mixture was associated with a significant fall in blood pressure between induction and intubation, whereas this was not found with gallamine.

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