Leaf extracts fromMoricandia arvensispromote antiproliferation of human cancer cells, induce apoptosis, and enhance antioxidant activity

2009 ◽  
Vol 33 (1) ◽  
pp. 20-27 ◽  
Author(s):  
Ines Skandrani ◽  
Jihed Boubaker ◽  
Wissem Bhouri ◽  
Ilef Limem ◽  
Soumaya Kilani ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Cancer Cells ◽  
Human Cancer ◽  
Leaf Extracts ◽  
Human Cancer Cells

Evaluation of antioxidant activity and cytotoxicity of polyfluorinated diarylacetylenes and indoles toward human cancer cells

2019 ◽  
Vol 226 ◽  
pp. 109353 ◽  
Author(s):  
Olga Zakharova ◽  
Georgy Nevinsky ◽  
Larisa Politanskaya ◽  
Dmitry Baev ◽  
Ludmila Ovchinnikova ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Cancer Cells ◽  
Human Cancer ◽  
Human Cancer Cells

scholarly journals Antioxidant Activity, Total Phenolics and Taxol Contents Response of Hazel (Corylus avellana L.) Cells to Benzoic Acid and Cinnamic Acid

2012 ◽  
Vol 40 (1) ◽  
pp. 69 ◽  
Author(s):  
Ebrahim BEMANI ◽  
Faezeh GHANATI ◽  
Laleh YOUSEFZADEH BOROUJENI ◽  
Faezeh KHATAMI
Keyword(s):  
Antioxidant Activity ◽  
Benzoic Acid ◽  
Cancer Cells ◽  
Cinnamic Acid ◽  
Human Cancer ◽  
Corylus Avellana ◽  
Cell Extract ◽  
Phenolic Contents ◽  
Human Cancer Cells ◽  
Corylus Avellana L

Hazel (Corylus avellana L.) plant has been recently introduced as a plant with the ability to produce Taxol. In the present research effects of different concentrations of benzoic acid and cinnamic acid on the phenolic compounds, Taxol content, and antioxidant activity of extracts of suspension-cultured hazel cells were investigated. The cells were treated with different concentrations of benzoic acid (0, 0.5, and 1 mM) and cinnamic acid (0, 0.15, 0.3 and 0.6 mM) on day 7 of subculture and were harvested on day 14. Benzoic acid in higher concentrations increased Taxol (4 fold of the control) and antioxidant activity of the cell extract. Cinnamic acid supply did not bring remarkable increase in Taxol content but increased phenolic contents and antioxidant activity of hazel cells extract. Interestingly, the extract of hazel cells showed more cytotoxicity for human cancer cells than pure Taxol. Further investigations may suggest the extract of cinnamic- and benzoic acid- fed hazel cells for treatment of cancer cells.

Cytotoxic effect of Berberis libanotica roots extracts on human cancer cells and antioxidant activities

2017 ◽  
Vol 6 (6) ◽  
pp. 311-317
Author(s):  
Kamar Hamade ◽  
◽  
Louna Karam ◽  
Jean Habib ◽  
Raghida Abou Merhi ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Cancer Cells ◽  
Cytotoxic Effect ◽  
Antioxidant Activities ◽  
Human Cancer ◽  
Medicinal Tree ◽  
Human Cancer Cells ◽  
Promising Source ◽  
Ht 29 ◽  
Mcf 7

In the present study, we evaluated the cytotoxic effect and the antioxidant activity of methanolic and ethanolic roots extracts obtained from Berberis libanotica a Lebanese medicinal tree. Cytotoxic activity was assessed on the colon cancer HT 29, HCT 116, Caco-2 and breast cancer MCF-7 and MDA-MB-231cell lines, using the MTT viability assay. Both extracts inhibited cancer cells proliferation in a doseand time depending manner without being cytotoxic against the normal MCF-10 cell line. Our results suggest that methanolic extract could induce a caspase-independent cell death in the colon and breast tumor cells HT 29 and MCF-7, respectively. DPPH and FRAP assays showed a moderate to strong antioxidant activity of the methanolic and ethanolic extracts with EC50 values of 0.13 ± 0.001 and 0.1± 0.002 mg/ml, respectively. Collectively, these findings suggest that Berberis libanotica roots could serve as a promising source of antioxidant and anticancer bioactive compounds.

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