Advances in brain imaging have revolutionised the study of synaesthesia and have enormous potential in educating us about the aetiology of this unusual condition. Brain scans provide clear and irrefutable evidence of how synaesthetic sensations are grounded in the brain. ‘Synaesthesia in the brain’ describes several seminal studies in the brain imaging of synaesthesia, which have involved a mixture of techniques: positron emission tomography, functional magnetic resonance imaging, and diffusion tensor imaging. Two key questions have been considered: do synaesthetes have functional or structural differences in their brains, and are their direct or indirect connections between the different parts of the brains that are triggered by different senses?