scholarly journals Effect of Ethanol Induced Occlusion of the Renal Artery in Rabbit Kidney Implanted with VX2 Carcinoma

1989 ◽  
Vol 30 (5) ◽  
pp. 535-539 ◽  
Author(s):  
Shigeki Imai ◽  
Y. Kajihara ◽  
S. Nishishita ◽  
T. Hayashi
Keyword(s):  
Renal Artery ◽  
Rabbit Kidney ◽  
Vx2 Carcinoma

Effect of Ethanol Induced Occlusion of the Renal Artery in Rabbit Kidney Implanted with VX2 Carcinoma

1989 ◽  
Vol 30 (5) ◽  
pp. 535-539 ◽  
Author(s):  
S. Imai ◽  
Y. Kajihara ◽  
S. Nishishita ◽  
T. Hayashi
Keyword(s):  
Renal Artery ◽  
Tumor Cells ◽  
Barium Sulphate ◽  
Renal Tumors ◽  
Absolute Ethanol ◽  
Rabbit Kidney ◽  
Control Group ◽  
Short Term ◽  
Vx2 Carcinoma ◽  
Repeat Angiography

The effects of injection of absolute ethanol into the renal artery were investigated in 13 rabbit kidneys previously implanted with VX2 carcinoma. Eight rabbits with implanted tumors served as controls. The effects were evaluated by angiography and histology. Three days after implantation, tumors were demonstrated by angiography as relatively hypovascular areas in the subcapsular cortex of the kidneys. Following angiography, absolute ethanol (0.3 ml/kg) was injected into the renal artery. Repeat angiography with barium sulphate was performed after an additional 3 days (10 ethanol treated animals, 2 controls), 10 days (2 treated, 1 control) or 14 days (1 treated, 0 control). In treated animals the tumors were markedly smaller in comparison with those of the control group. The occlusion procedure, however, did not completely eradicate tumor cells. The histologic study of the implanted tumor confirmed the findings previously reported that viable tumor cells still remained in the peripheral portions of infarcted areas. This study demonstrated the beneficial, though not curative, short-term effects of transcatheter renal artery treatment with absolute ethanol in malignant renal tumors.

Blood supply and distribution of albumin and red cells in rabbit kidney

1962 ◽  
Vol 202 (4) ◽  
pp. 805-811 ◽  
Author(s):  
Maria Serratto ◽  
C. Larkin Flanagan ◽  
David P. Earle
Keyword(s):  
Renal Artery ◽  
Blood Supply ◽  
Collateral Circulation ◽  
Renal Cortex ◽  
Renal Parenchyma ◽  
Red Cells ◽  
Rabbit Kidney ◽  
Left Renal Artery ◽  
Renal Pedicle ◽  
Supply And Distribution

Intravenously administered I131 albumin (RISA) is more concentrated in medulla than in cortex of the normal rabbit kidney. In contrast, labeled erythrocytes are more concentrated in normal rabbit renal cortex than in medulla. Collateral circulation to rabbit renal parenchyma arises from capsular and ureteral arteries. The magnitudes of these two blood supplies are small and roughly equal. Both cortex and medulla receive blood from both groups of collaterals. When capsular vessels alone supply the kidney, renal weight and concentrations of RISA and labeled erythrocytes increase progressively with time up to 1 hr. This suggests a preponderance of arterial over venous and lymphatic collaterals after acute renal pedicle occlusion. RISA concentration of the contralateral medulla of the rabbit whose left renal artery and vein have been occluded increases rapidly and remains high for 1 hr as compared to control animals.

Intraarterial Doxorubicin Infusion Treatment with and without Occlusion of the Renal Artery in Rabbit Renal VX-2 Carcinoma

1987 ◽  
Vol 28 (4) ◽  
pp. 467-471 ◽  
Author(s):  
G. Gadeholt ◽  
J. H. Göthlin
Keyword(s):  
Renal Artery ◽  
Artery Occlusion ◽  
Vascular Trauma ◽  
Vascular Lesions ◽  
Rabbit Kidney ◽  
Arterial Spasm ◽  
Short Period ◽  
Renal Artery Occlusion ◽  
Physiologic Saline ◽  
Iatrogenic Vascular Trauma

The aim of this investigation was to establish an animal model for studying fractionated intraarterial treatment of a rabbit kidney VX-2 carcinoma. As repeated catheterizations and drug infusions may cause vascular lesions, we wanted to find whether the rabbit renal artery could be catheterized several times within a short period of time with acceptable iatrogenic vascular trauma. Each of 3 groups of rabbits with implanted renal VX-2 carcinoma were treated 3 times with either 1) temporary renal artery occlusion combined with infusion (occlusion infusion) of a) physiologic saline (OIS) or b) doxorubicin (OID), or 2) with renal artery infusion of doxorubicin. OID was administered in 20 of 21 attempts, OIS in 21 of 24, and infusion of doxorubicin in 20 of 21 attempts. Renal arterial spasm was seen in 5 of 22 rabbits, rarely at the first catheterization, more frequently during the second and third. Permanent iatrogenic vascular trauma occurred in 4 of 15 rabbits after the second and third occlusion infusion. We conclude that the rabbit kidney with implanted VX-2 carcinoma may be a useful model for testing fractionation schemes for multiple intraarterial infusions of antineoplastic drugs.

TH-C-I-609-02: Refill Curve Simulations of Rabbit Kidney and of Liver with VX2 Carcinoma

2005 ◽  
Vol 32 (6Part20) ◽  
pp. 2154-2154
Author(s):  
T Potdevin ◽  
J Fowlkes ◽  
A Moskalik ◽  
P Carson
Keyword(s):  
Rabbit Kidney ◽  
Vx2 Carcinoma

ULTRASOUND APPEARANCE AND EARLY DETECTION OF Vx2 CARCINOMA IN THE RABBIT KIDNEY

1989 ◽  
Vol 30 (2) ◽  
pp. 88-96 ◽  
Author(s):  
N. Ackerman ◽  
D.A. Haager ◽  
J.V. Kaude
Keyword(s):  
Early Detection ◽  
Rabbit Kidney ◽  
Vx2 Carcinoma

The Relation between the Excretion of Sodium and Water and the Perfusion Pressure in the Isolated, Blood-Perfused, Rabbit Kidney, with Special Reference to Changes Occurring in Clip-Hypertension

1976 ◽  
Vol 50 (3) ◽  
pp. 223-236 ◽  
Author(s):  
J. M. A. Thompson ◽  
C. J. Dickinson
Keyword(s):  
Blood Pressure ◽  
Renal Artery ◽  
Sodium Excretion ◽  
Perfusion Pressure ◽  
Sympathetic Innervation ◽  
Functional Change ◽  
Rabbit Kidney ◽  
Left Renal Artery ◽  
Water Excretion ◽  
Pressure Threshold

1. The sodium and water excretion rates of rabbit kidneys were studied when isolated and perfused at known pressure with blood from another normal anaesthetized rabbit. Studies at several different perfusion pressures confirmed that a small rise in perfusion pressure caused a large rise in sodium excretion and that the potential sodium-excreting ability of the isolated kidney was high. The curve obtained could be closely fitted by a quadratic equation which allowed an estimate to be made of the blood pressure below which no urine is formed, i.e. the ‘theoretical perfusion pressure threshold’. For normal kidneys this was 55·4 mmHg. 2. A group of rabbits had a silver clip applied to the left renal artery and, 3–6 weeks later, the eight most hypertensive animals were selected to provide their kidneys for perfusion. Both kidneys were perfused simultaneously. The clip on the left renal artery was removed immediately before perfusion and the cannula placed distal to the stenosis in the post-stenotic dilatation. The function curves of these kidneys were compared with the curves obtained from normal kidneys. 3. The untouched kidney contralateral to the clip was found to require a significantly higher perfusion pressure (71·7 mmHg) for it to achieve a given sodium excretion rate and, surprisingly, the clipped kidney showed a similar functional change (76·4 mmHg). In other words the positions of both function curves were shifted though their slopes were not much changed. 4. Both kidneys in single-clip-hypertension appear to adapt or reset their sodium excretory behaviour. The resetting in the untouched kidney allows hypertension to be sustained without undue sodium loss. Aldosterone probably contributes little to the resetting. We infer, indirectly, that the normal kidney may, to a significant extent, restrain sodium excretion by virtue of its sympathetic innervation. We also opine that the kidney cannot be assigned fixed intrinsic functional properties on which a renal sodium-handling theory of long-term blood pressure regulation can be firmly based.

Reduction of Potassium in Kidney Proximal Tubules to Aid in Electron Probe X-Ray Microanalysis of Calcium

1985 ◽  
Vol 43 ◽  
pp. 474-475
Author(s):  
A. LeFurgey ◽  
P. Ingram ◽  
L.J. Mandel
Keyword(s):  
Smooth Muscle ◽  
Proximal Tubule ◽  
Electron Probe ◽  
Clinical Applications ◽  
Proximal Tubules ◽  
Rabbit Kidney ◽  
Target Cells ◽  
X Ray ◽  
Freeze Dried

For quantitative determination of subcellular Ca distribution by electron probe x-ray microanalysis, decreasing (and/or eliminating) the K content of the cell maximizes the ability to accurately separate the overlapping K Kß and Ca Kα peaks in the x-ray spectra. For example, rubidium has been effectively substituted for potassium in smooth muscle cells, thus giving an improvement in calcium measurements. Ouabain, a cardiac glycoside widely used in experimental and clinical applications, inhibits Na-K ATPase at the cell membrane and thus alters the cytoplasmic ion (Na,K) content of target cells. In epithelial cells primarily involved in active transport, such as the proximal tubule of the rabbit kidney, ouabain rapidly (t1/2= 2 mins) causes a decrease2 in intracellular K, but does not change intracellular total or free Ca for up to 30 mins. In the present study we have taken advantage of this effect of ouabain to determine the mitochondrial and cytoplasmic Ca content in freeze-dried cryosections of kidney proximal tubule by electron probe x-ray microanalysis.

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