In vitro–in vivocorrelation study for the dermatopharmacokinetics of terbinafine hydrochloride topical cream

2012 ◽  
Vol 39 (9) ◽  
pp. 1372-1377 ◽  
Author(s):  
Suwadee Saeheng ◽  
Wichit Nosoongnoen ◽  
Supenya Varothai ◽  
Korbtham Sathirakul
Keyword(s):  
Terbinafine Hydrochloride ◽  
Topical Cream

Identification of critical formulation parameters affecting the in vitro release, permeation, and rheological properties of the acyclovir topical cream

2020 ◽  
Vol 590 ◽  
pp. 119914
Author(s):  
Nahid S. Kamal ◽  
Yellela S.R. Krishnaiah ◽  
Xiaoming Xu ◽  
Ahmed S. Zidan ◽  
Sameersingh Raney ◽  
...  
Keyword(s):  
Rheological Properties ◽  
In Vitro Release ◽  
Topical Cream ◽  
Formulation Parameters ◽  
Vitro Release

DEVELOPMENT AND IN VITRO EVALUATION OF PHYTOSOME OF TERBINAFINE HYDROCHLORIDE FOR ORAL DRUG DELIVERY

2020 ◽  
pp. 85-94
Author(s):  
SHIVAM SHARMA ◽  
VIVEK
Keyword(s):  
Fourier Transforms ◽  
Oral Drug Delivery ◽  
In Vitro Release ◽  
Molar Ratio ◽  
Oral Drug ◽  
In Vitro Evaluation ◽  
Terbinafine Hydrochloride ◽  
Membrane Technique ◽  
Terbinafine Hcl

Objective: The purpose of this study was to develop and in vitro evaluation phytosome of terbinafine HCL to enhance the bioavailability for oral route. Methods: The novel phytosome of terbinafine hydrochloride (TFH) was formulated with the molar ratio (1:2) of drug and phospholipid by using solvent evaporation technique. The resulting TFH-PC was determined by means of particle size analyzer (PSA), percentage yield, microscopy, drug content, transmission electron microscopy (TEM). Substantial contact of terbinafine HCL with phospholipids was completed through Fourier transforms infrared spectroscopy (FTIR). Results: The all relevant results of TFH-PC were showed that the percentage entrapment efficiency of formulation was found in 76% to 90%. In vitro release data were exhibited approximately 65% to 79% of the drug released from the TFH-PC formulation by using dialysis membrane technique. Therefore, Formulation (F3) was accomplished that phytosome contain the superior physical characters and compatibility with drug and phospholipids than to make it easy to overcome the competence of drug to pass the lipid-rich bio-membrane. Conclusion: In present work, terbinafine loaded phytosome was formulated for increasing the oral bioavailability of selected drug. Hence, TER-HCL phytosome were effectively improved the absorption of drug in form of phospholipids complex.

scholarly journals In vitro assessment of pharmaceutical potential of ethosomes entrapped with terbinafine hydrochloride

2016 ◽  
Vol 7 (3) ◽  
pp. 453-461 ◽  
Author(s):  
Syed Ahmed Iizhar ◽  
Ismail Ahmed Syed ◽  
Rukhsana Satar ◽  
Shakeel Ahmed Ansari
Keyword(s):  
Terbinafine Hydrochloride ◽  
In Vitro Assessment

scholarly journals In Vitro Susceptibility of Talaromyces Marneffei In Malaysia: Comparison of Yeast and Mycelial Phases

2021 ◽  
Author(s):  
Xue Ting Tan ◽  
Nurliyana binti Mohd Shuhairi ◽  
Stephanie Jane Ginsapu ◽  
Surianti Binti Shukor ◽  
Fairuz Binti Amran
Keyword(s):  
Amphotericin B ◽  
Geometric Mean ◽  
Antifungal Susceptibility ◽  
Etiologic Agent ◽  
Mycelial Form ◽  
In Vitro Susceptibility ◽  
Terbinafine Hydrochloride ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome

Abstract Talaromyces marneffei is an etiologic agent of talaromycosis. It can cause serious complications and death in immunocompromised patients, particularly in acquired immunodeficiency syndrome (AIDS) patients. This infectious disease is endemic in Southeast Asia including Malaysia. To date, published reports on the antifungal susceptibility profile of T. marneffei is very limited. The objective of this study is to determine the minimum inhibitory concentration (MIC) of T. marneffei in yeast and mycelial phases in Malaysia. In the year 2020, 27 clinical strains of T. marneffei were received from various hospitals in Malaysia. The identification was carried out using microscopic, macroscopic and molecular methods. Following that, the susceptibility of each isolate in both yeast and mycelial form to thirteen common antifungals was performed according to the broth microdilution in Clinical & Laboratory Standards Institute (CLSI) M38 method. The antifungals tested were anidulafungin, micafungin sodium, caspofungin diacetate, 5-fluorocytosine, amphotericin B and terbinafine hydrochloride, posaconazole, voriconazole, itraconazole, ketoconazole, ravuconazole, clotrimazole and isavuconazole. The geometric mean of all antifungals other than anidulafungin, micafungin sodium, caspofungin diacetate and 5-fluorocytosine against T. marneffei mould (mycelial) were >2 μg/ml. However, the geometric mean of all antifungals against T. marneffei yeast was <2 μg/ml. Our in vitro data suggests promising activities of amphotericin B, terbinafine hydrochloride, posaconazole, voriconazole, itraconazole, ketoconazole, ravuconazole, clotrimazole and isavuconazole against yeast and mould phases of T. marneffei.

scholarly journals In vitro Evaluationof the Antimi- crobial Activity of a Topical Skin Preparation Containing 0.1% Polyhexanide vs a Topical Skin Prepa-ration Containing 1% Silver Sulfadiazine

2021 ◽  
Vol 6 (2) ◽  
pp. 1-7
Author(s):  
Barbara Maglione ◽  
Keyword(s):  
Antibacterial Activity ◽  
Positive Control ◽  
Negative Control ◽  
Silver Sulfadiazine ◽  
Bacterial Strains ◽  
Skin Preparation ◽  
E Coli ◽  
Topical Cream ◽  
Significant Difference

Aim: The effective in vitro antibacterial activity on Staphylococcus aureus (S.aureus), Pseudomonas aeruginosa (P.aeruginosa), Klebsiella pneumoniae (K.pneumoniae),Escherichia coli (E.Coli) and the combination of S.aureus and K. pneumonia of a topical cream based on 0.1% polyhexanidewas compared to a topical cream based on 1% silver sulfadiazine.A topical cream containing 0,1% gentamicin was used as a positive control and a white blank topical cream was used as negative control. Materials and Methods: The in vitro antibacterial activities were determined by agar well-diffusion assay. Two-way Analysis of Variance (ANOVA) was used to test, by calculation of P-values, for significant antiseptic activity in bacteria treated with 0.1% polyhexanide topical cream compared to 1% silver sulfadiazine and to the negative and positive controls. Results: Among the derivatives tested, all the active topical creams analyzed were able to reduce microbial strains. The topical cream based on 0.1% polyhexanide showed a significantly higher antibacterial efficacy in comparison to the topical cream based on 1% silver sulfadiazine on S. aureus and K. pneumonia and on the combination of S. aureus and K. pneumoniae,while no significant difference was detected between the antibacterial activity of the two topical creams against P. aeruginosa and E. coli. Conclusion: These results provide a further insight into the antibacterial activity of polyhexanide and its non-inferiority compared to silver sulfadiazine towards certain bacterial strains (P. aeruginosa and E. coli) and superiority towards other (S. aureus and K. pneumoniae)and support the use of 0.1% Polyhexanide topical preparation for the treatment of wounds that are infected or at risk of infection.

scholarly journals Polyurethanes as New Excipients in Nail Therapeutics

Pharmaceutics ◽  
2018 ◽  
Vol 10 (4) ◽  
pp. 276 ◽  
Author(s):  
Barbara Valdes ◽  
Ana Serro ◽  
Joana Marto ◽  
Rui Galhano dos Santos ◽  
Elena Cutrín Gómez ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Polymer Concentration ◽  
In Vitro Release ◽  
Nail Plate ◽  
Oral Drugs ◽  
Terbinafine Hydrochloride ◽  
Nail Lacquer ◽  
Nail Infection ◽  
Vitro Release

Onychomycosis affects about 15% of the population. This disease causes physical and psychosocial discomfort to infected patients. Topical treatment (creams, solutions, gels, colloidal carriers, and nail lacquers) is usually the most commonly required due to the high toxicity of oral drugs. Currently, the most common topical formulations (creams and lotions) present a low drug delivery to the nail infection. Nail lacquers appear to increase drug delivery and simultaneously improve the effectiveness of treatment with increased patient compliance. These formulations leave a polymer film on the nail plate after solvent evaporation. The duration of the film residence in the nail constitutes an important property of nail lacquer formulation. In this study, a polyurethane polymer was used to delivery antifungals drugs, such as terbinafine hydrochloride (TH) and ciclopirox olamine (CPX) and the influence of its concentration on the properties of nail lacquer formulations was assessed. The nail lacquer containing the lowest polymer concentration (10%) was the most effective regarding the in vitro release, permeation, and antifungal activity. It has also been demonstrated that the application of PU-based nail lacquer improves the nail plate, making it smooth and uniform and reduces the porosity contributing to the greater effectiveness of these vehicles. To conclude, the use of polyurethane in nail formulations is promising for nail therapeutics.

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