Expression levels of mRNA for neurosteroidogenic enzymes 17β-HSD, 5α-reductase, 3α-HSD and cytochrome P450 aromatase in the fetal wild type and SF-1 knockout mouse brain

2014 ◽  
Vol 40 (1) ◽  
pp. 44-48 ◽  
Author(s):  
Tanja Spanic ◽  
Teja Fabjan ◽  
Gregor Majdic
2021 ◽  
Vol 38 (2) ◽  
pp. 247-252
Author(s):  
Guler Unal ◽  
Emily Marquez ◽  
Mara H. O'brien ◽  
Pericles Stavropoulos ◽  
Ian P. Callard

In this study, we aimed to clone brain-derived Cyp19b and ovary-derived Cyp19a the P450 aromatase gene isoforms and to indicate the expression levels of these genes in the hypothalamus and ovary tissues from reproductively arrested ovarian development (RA) and non-arrested ovarian development (RN) Alburnus tarichi from Lake Van, Turkey. The expression levels of Cyp19b and Cyp19a genes were predominant in the hypothalamus and ovary, respectively. The level of Cyp19b mRNA was significantly lower in the hypothalamus and ovary from RA fish than in the hypothalamus and ovary from RN fish (P<0.05). The expression level of Cyp19a was significantly lower in the ovary of RA fish (P<0.05) than RN fish while no difference was found in the hypothalamus of both RA and RN fish (P<0.05). According to these findings, we suggest that the RA fish represent a segment of the population and these fish may be more sensitive to endocrine disruption compound/s than others.


1997 ◽  
Vol 16 (6) ◽  
pp. 769-777 ◽  
Author(s):  
INHO CHOI ◽  
DERYL L. TROYER ◽  
DEAN L. CORNWELL ◽  
KATHY R. KIRBY-DOBBELS ◽  
WERNER R. COLLANTE ◽  
...  

2004 ◽  
Vol 21 (4) ◽  
pp. 417-425 ◽  
Author(s):  
Yasuhisa Kobayashi ◽  
Tohru Kobayashi ◽  
Masaru Nakamura ◽  
Tomoki Sunobe ◽  
Craig E. Morrey ◽  
...  

Author(s):  
Gilles-Eric Seralini ◽  
Alexey Tomilin ◽  
Pierrı̈ck Auvray ◽  
Celine Nativelle-Serpentini ◽  
Pascal Sourdaine ◽  
...  

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