High blood hemoglobin concentration as risk factor of major atherosclerotic cardiovascular events in 114,159 healthy men and women in the Apolipoprotein MOrtality RISk study (AMORIS)

2011 ◽  
Vol 44 (5) ◽  
pp. 476-486 ◽  
Author(s):  
Ingar Holme ◽  
Are H Aastveit ◽  
Niklas Hammar ◽  
Ingmar Jungner ◽  
Göran Walldius
Keyword(s):  
Risk Factor ◽  
Mortality Risk ◽  
Cardiovascular Events ◽  
Hemoglobin Concentration ◽  
Men And Women ◽  
Healthy Men ◽  
Blood Hemoglobin ◽  
Blood Hemoglobin Concentration

scholarly journals The definition of anemia: what is the lower limit of normal of the blood hemoglobin concentration?

Blood ◽  
2006 ◽  
Vol 107 (5) ◽  
pp. 1747-1750 ◽  
Author(s):  
Ernest Beutler ◽  
Jill Waalen
Keyword(s):  
Normal Distribution ◽  
Lower Limit ◽  
Population Distribution ◽  
Hemoglobin Concentration ◽  
Blood Hemoglobin ◽  
Definition Of ◽  
Lower Limit Of Normal ◽  
Blood Hemoglobin Concentration

The diagnosis of anemia is an important aspect of the practice of hematology. The first step is to decide whether the patient is, in fact, anemic. Unless earlier blood counts are available, and they often are not, the physician must make his or her decision on the basis of the population distribution of hemoglobin values. How likely is it that the patient's hemoglobin value lies below the normal distribution; that is, “the lower limit”?

scholarly journals Curvilinear VO2:Power Output Relationship in a Ramp Test in Professional Cyclists: Possible Association with Blood Hemoglobin Concentration.

2002 ◽  
Vol 52 (1) ◽  
pp. 95-103 ◽  
Author(s):  
Alejandro Lucía ◽  
Jesús Hoyos ◽  
Alfredo Santalla ◽  
Margarita Pérez ◽  
José L. Chicharro
Keyword(s):  
Power Output ◽  
Hemoglobin Concentration ◽  
Ramp Test ◽  
Blood Hemoglobin ◽  
Blood Hemoglobin Concentration

scholarly journals Splenic contraction-induced reversible increase in hemoglobin concentration in intermittent hypoxia

1999 ◽  
Vol 86 (1) ◽  
pp. 181-187 ◽  
Author(s):  
Ichiro Kuwahira ◽  
Uguri Kamiya ◽  
Tokuzen Iwamoto ◽  
Yoshihiro Moue ◽  
Tetsuya Urano ◽  
...  
Keyword(s):  
Intermittent Hypoxia ◽  
Hemoglobin Concentration ◽  
Hypoxic Exposure ◽  
Plasma Epinephrine ◽  
Receptor Stimulation ◽  
Blood Hemoglobin ◽  
Underlying Mechanisms ◽  
Blood Hemoglobin Concentration

The effect of intermittent hypoxia (IHx) on blood hemoglobin concentration ([Hb]) and the underlying mechanisms were studied in rats exposed to 10% O2, 1 h/day, for up to 5 wk. IHx protocols with longer daily hypoxic exposure show persistent polycythemia; however, it is unknown whether [Hb] increases transiently during hypoxia in protocols without polycythemia. Hypoxia produced a reversible [Hb] increase after 4 days of IHx but not in normoxic controls (NxC) or after shorter period of IHx. Splenectomy abolished the phenomenon. Plasma epinephrine and norepinephrine levels during hypoxia were comparable in IHx and NxC groups, but the epinephrine-induced [Hb] increase was larger in IHx. The α1- and α2-adrenoreceptor blockade (phentolamine) and α2-blockade (yohimbine) abolished the [Hb] increase of IHx rats. Conversely, α2-receptor stimulation (oxymetazoline) increased [Hb] during normoxia in IHx but not in NxC. In conclusion, this IHx protocol results in reversible [Hb] increases during hypoxia via splenic contraction mediated by increased α2-adrenoreceptor response. This may protect O2supply during hypoxia without the cardiovascular burden of polycythemia during normoxia.

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