Life events are positively associated with luteinizing hormone in middle age adult men: role of cortisol as a third variable

ABSTRACT The role of luteinizing hormone (LH) for the maintenance of pregnancy, parturition and lactation was investigated by immunological and histochemical methods in the rat. Neutralisation of endogenous rat-LH with Rabbit-Anti-Bovine-LH-Serum (selective hypophysectomy) from days 7-12 of pregnancy resulted in reabsorption of the foetuses and the reappearance of strong 20α-hydroxysteroid-dehydrogenase (20α-OHSD) activity in the corpora lutea (CL) of pregnancy, which normally show no such activity at that time. This effect could be prevented in part by concurrent pregnenolone administration and fully by progesterone, but was not influenced by oestrogen or prolactin. It is concluded that in early pregnancy LH is the main luteotrophic hormone in the rat even though prolactin might act synergistically with it. Antiserum treatment after the 12th day of gestation had no influence on the state or duration of pregnancy or on parturition. LH-injections during the first half of pregnancy had no luteolytic effects i. e. they did not activate 20α-OHSD activity. After day 16 they advanced the reappearance of the enzyme, but delayed parturition or resulted in stillbirths. Neither LH nor antiserum seemed to alter lactation. Since progesterone prevented both the termination of pregnancy and the recurrence of 20α-OHSD activity, it should have some regulatory properties on the enzyme. It is discussed whether the gonadotrophin-dependent progesterone level could regulate the 20α-OHSD activity rather than result from it.

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FEEDBACK CONTROL OF FSH IN THE MALE: ROLE OF OESTROGEN

Acta Endocrinologica ◽

10.1530/acta.0.0740449 ◽

1973 ◽

Vol 74 (3) ◽

pp. 449-460 ◽

Cited By ~ 11

Author(s):

Patrick C. Walsh ◽

Ronald S. Swerdloff ◽

William D. Odell

Keyword(s):

Luteinizing Hormone ◽

Follicle Stimulating Hormone ◽

Oestrogen Therapy ◽

Serum Concentrations ◽

Elderly Men ◽

Normal Range ◽

Oestrogen Treatment ◽

Serum Lh ◽

Higher Doses

ABSTRACT Serum follicle stimulating hormone (FSH) and luteinizing hormone (LH) were measured by radioimmunoassay in a group of elderly men following castration and oestrogen therapy. Prior to orchiectomy, mean serum concentrations of LH and FSH were within the normal range. Two days following castration, serum LH concentrations increased in all eight patients; higher levels of LH were subsequently measured in all but one patient after periods of time ranging from 49 to 210 days. Serum FSH levels, measured in three patients following castration, increased in a pattern parallel to LH changes. Ethinyl oestradiol (EOe) in doses ranging from 5 to 300 μg/day was administered to ten men who had been castrated 3 to 72 months earlier. Oestrogen treatment suppressed both LH and FSH in a parellel manner in nine of ten patients. LH was first suppressed to intact levels in one of eight patients treated with 20 μg/day of EOe, in two of six patients treated with 50 μg/day, and in one patient by 80 μg/day. FSH was not suppressed to precastration levels until 50 μg/day of EOe was administered; this dose suppressed three of six patients. Higher doses of EOe (150–300 μg/day) suppressed both LH and FSH to levels below the sensitivity of the assay. These data fail to demonstrate any differential effect of oestrogen on LH and FSH release.

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Role of luteinizing hormone receptor in the ontogeny and progression of adrenocortical tumors in transgenic mice expressing SV40Tag under the inhibin-[alpha] promoter

Endocrine Abstracts ◽

10.1530/endoabs.41.oc9.2 ◽

2016 ◽

Author(s):

Milena Doroszko ◽

Marcin Chrusciel ◽

Kirstine Belling ◽

Susanna Vuorenoja ◽

Marlene Dalgaard ◽

...

Keyword(s):

Luteinizing Hormone ◽

Transgenic Mice ◽

Hormone Receptor ◽

Luteinizing Hormone Receptor ◽

Adrenocortical Tumors

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Stressful life events induce graves' disease: further evidence for the role of stress as an inducing factor in graves' disease

Endocrine Abstracts ◽

10.1530/endoabs.63.p1196 ◽

2019 ◽

Author(s):

Ifigenia Kostoglou-Athanassiou ◽

Lambros Athanassiou ◽

Eleni Xanthakou ◽

Panagiotis Spyropoulos ◽

Thomais Kalogirou ◽

...

Keyword(s):

Life Events ◽

Stressful Life Events ◽

Stressful Life ◽

Graves Disease

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Sleep Reactivity and Psychological Health in Normal Sleepers: the moderating role of stress

10.31234/osf.io/nxz42 ◽

2018 ◽

Author(s):

Jason G. Ellis ◽

Sarah Allen ◽

Michael Perlis ◽

Michael Grandner ◽

Maria Gardani ◽

...

Keyword(s):

Life Events ◽

Psychological Health ◽

Public Health Campaign ◽

Health Campaign ◽

Cross Sectional Survey ◽

Cross Sectional ◽

Dysfunctional Cognitions ◽

The Relationship ◽

Moderating Role

The aim of the present study was to determine whether normal sleepers with vulnerability to insomnia, via high sleep reactivity, demonstrate more sleep-related dysfunctional cognitions and behaviours and poorer psychological health compared to those who are not vulnerable. Further, the influence of stress on the relationship between sleep reactivity and psychological health was also examined. A cross-sectional survey of 737 young adult ‘normal’ sleepers from the general population was undertaken. Results indicated normal sleepers vulnerable to insomnia demonstrated more sleep-related dysfunctional cognitions and behaviours as well as poorer psychological health compared to those not vulnerable. Furthermore, the relationship between sleep reactivity and psychological health was moderated by perceived stress over the previous month and life events over the previous year. Therefore, identifying and supporting those who are vulnerable to insomnia may be a fruitful avenue for preventative public health campaign to mitigate both insomnia and poor psychological health.

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Role of Ca2+ and Na+ on luteinizing hormone release from the calf pituitary

AJP Endocrinology and Metabolism ◽

10.1152/ajpendo.1988.255.4.e469 ◽

1988 ◽

Vol 255 (4) ◽

pp. E469-E474

Author(s):

J. P. Kile ◽

M. S. Amoss

Keyword(s):

Luteinizing Hormone ◽

Ionophore A23187 ◽

Channel Blockers ◽

Hormone Release ◽

Primary Cells ◽

Rat Pituitary ◽

Voltage Dependent ◽

Lh Release ◽

Ca2 Channels

It has been proposed that gonadotropin-releasing hormone (GnRH) stimulates Ca2+ entry by activation of voltage-independent, receptor-mediated Ca2+ channels in the rat gonadotroph. Little work has been done on the role of calcium in GnRH-induced luteinizing hormone (LH) release in species other than the rat. Therefore, this study was done to compare the effects of agents that alter Ca2+ or Na+ entry on LH release from calf anterior pituitary primary cells in culture. GnRH (100 ng/ml), Ca2+ ionophore A23187 (2.5 microM), and the depolarizing agent ouabain (0.1-10 microM) all produced significant increases (P less than 0.05) in LH release; these effects were significantly reduced when the cells were preincubated with the organic Ca2+ channel blockers nifedipine (1-10 microM) and verapamil (1-10 microM) and with Co2+ (0.01-1 mM). The effect of ouabain was inhibited by tetrodotoxin (TTX; 1-10 nM) as well as by nifedipine at 0.1-10 microM. In contrast to its effect on rat pituitary LH release, TTX significantly inhibited GnRH-stimulated LH release at 1-100 nM. These results suggest that GnRH-induced LH release may employ Ca2+ as a second messenger in bovine gonadotrophs and support recent speculation that GnRH-induced Ca2+ mobilization may in part be voltage dependent.

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