Formulation andin vitrocharacterization of poly(dl-lactide-co-glycolide)/Eudragit RLPO or RS30D nanoparticles as an oral carrier of levofloxacin hemihydrate

2015 ◽  
pp. 1-9
Author(s):  
Azza A. Hasan ◽  
Shereen A. Sabry ◽  
Marwa H. Abdallah ◽  
Dalia A. El-damasy
Keyword(s):  
Eudragit Rlpo

scholarly journals Evaluation and Optimization of Influence of Permeability Property and Concentration of Polymethacrylic Polymers on Microspheres of Metformin HCl

2014 ◽  
Vol 12 (2) ◽  
pp. 131-141 ◽  
Author(s):  
Ikramul Hasan ◽  
Shovan Paul ◽  
Sharmin Akhter ◽  
Navid Jubaer Ayon ◽  
Md Selim Reza
Keyword(s):  
Particle Size ◽  
Drug Release ◽  
Surface Morphology ◽  
Drug Loading ◽  
Liquid Paraffin ◽  
In Vitro Dissolution ◽  
Release Mechanism ◽  
Release Kinetic ◽  
Eudragit Rlpo ◽  
Metformin Hcl

Metformin HCl microspheres were prepared with the aim of increasing its bioavailability and decreasing gastrointestinal side effects by means of sustained action. Eudragit RSPO and Eudragit RLPO, polymers of different permeability characteristics were used to prepare different microspheres. Emulsification solvent evaporation technique using acetone as the internal phase and liquid paraffin as the external phase was the method of choice. Six formulations were prepared using two polymers. The effect of drug loading and polymeric property on the surface morphology, entrapment efficiency, particle size and release characteristics of the microspheres were examined. FTIR and DSC studies established compatibility of the drug with the polymers. SEM studies clearly revealed the effect of drug loading and polymeric nature on the surface morphology of the microspheres. Entrapment efficiencies were within 77.09-97.11% and particle size of all the batches were in the acceptable range. Release data were treated with different mathematical kinetic models. The drug release profile showed that Eudragit RSPO and Eudragit RLPO have opposite effect on drug release. On the other hand, increase in drug loading results in increased drug release. Kinetic modeling of in vitro dissolution profiles revealed that the drug release mechanism varies from diffusion controlled to anomalous type. Dhaka Univ. J. Pharm. Sci. 12(2): 131-141, 2013 (December) DOI: http://dx.doi.org/10.3329/dujps.v12i2.17611

Quantification of the types of water in Eudragit RLPO polymer and the kinetics of water loss using FTIR

2013 ◽  
Vol 458 (1) ◽  
pp. 90-98 ◽  
Author(s):  
Chompak Pirayavaraporn ◽  
Thomas Rades ◽  
Keith C. Gordon ◽  
Ian G. Tucker
Keyword(s):  
Water Loss ◽  
Kinetics Of ◽  
Eudragit Rlpo

scholarly journals Design, Development, and Optimization of Sterculia Gum-Based Tablet Coated with Chitosan/Eudragit RLPO Mixed Blend Polymers for Possible Colonic Drug Delivery

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Bipul Nath ◽  
Lila Kanta Nath
Keyword(s):  
Drug Delivery ◽  
Delivery System ◽  
Release Kinetics ◽  
Release Kinetic ◽  
Design Development ◽  
Colonic Delivery ◽  
Colonic Drug Delivery ◽  
Sterculia Urens ◽  
Eudragit Rlpo

The purpose of this study is to explore the possible applicability of Sterculia urens gum as a novel carrier for colonic delivery system of a sparingly soluble drug, azathioprine. The study involves designing a microflora triggered colon-targeted drug delivery system (MCDDS) which consists of a central polysaccharide core and is coated to different film thicknesses with blends of chitosan/Eudragit RLPO, and is overcoated with Eudragit L00 to provide acid and intestinal resistance. The microflora degradation property of gum was investigated in rat caecal medium. Drug release study in simulated colonic fluid revealed that swelling force of the gum could concurrently drive the drug out of the polysaccharide core due to the rupture of the chitosan/Eudargit coating in microflora-activated environment. Chitosan in the mixed film coat was found to be degraded by enzymatic action of the microflora in the colon. Release kinetic data revealed that the optimized MCDDS was fitted well into first-order model, and apparent lag time was found to be 6 hours, followed by Higuchi release kinetics. In vivo study in rabbits shows delayed , prolonged absorption time, decreased , and absorption rate constant (Ka), indicating a reduced systemic toxicity of the drug as compared to other dosage forms.

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