scholarly journals PREPARATION AND CHARACTERIZATION OF METHOCEL K4M, EUDRAGIT RLPO AND PEG 4000 LOADED CARBAMAZEPINE MICROSPHERES.

2018 ◽  
Vol 6 (7) ◽  
pp. 731-742
Author(s):  
Nasreen Sultana ◽  
Keyword(s):  
Peg 4000 ◽  
Eudragit Rlpo

Physicochemical Characterization of Solid Dispersions of Cefdinir with PVP K-30 and PEG 4000

2010 ◽  
Vol 3 (2) ◽  
pp. 948-956
Author(s):  
Kumar P ◽  
S Kumar ◽  
A Kumar ◽  
M Chander
Keyword(s):  
Solid Dispersions ◽  
Physicochemical Characterization ◽  
Drug Carriers ◽  
Dissolution Properties ◽  
Rate Of Dissolution ◽  
Peg 4000 ◽  
Release Studies ◽  
Crystalline Nature ◽  
Physical Mixtures

The purpose of this study was to prepare and characterize solid dispersions of the antibacterial agent Cefdinir with PEG 4000 and PVP K-30 with a view to improve its dissolution properties. Investigations of the properties of the dispersions were performed using release studies, X-ray powder diffraction (XRD) and Fourier transform infrared (FTIR). The results obtained showed that the rate of dissolution of Cefdinir was considerably improved when formulated in solid dispersions with PVP K-30 and PEG 4000 as compared with pure drug and physical mixtures. The results from XRD studies showed the transition of crystalline nature of drug to amorphous form, while FTIR studies demonstrated the absence of drug-carriers interaction.

Solid-State Characterization of PEG 4000/Monoolein Mixtures

2004 ◽  
Vol 37 (7) ◽  
pp. 2665-2667 ◽  
Author(s):  
Denny Mahlin ◽  
Annika Ridell ◽  
Göran Frenning ◽  
Sven Engström
Keyword(s):  
Solid State ◽  
Peg 4000 ◽  
Solid State Characterization

Size Controllable Synthesis and Characterization of CuO Nanostructure

2018 ◽  
Vol 915 ◽  
pp. 98-103 ◽  
Author(s):  
Duygu Candemir ◽  
Filiz Boran
Keyword(s):  
Freeze Drying ◽  
Chemical Precipitation ◽  
Precipitation Method ◽  
X Ray Diffraction ◽  
X Ray ◽  
Peg 4000 ◽  
Structure Morphology ◽  
Cuo Nanostructure

In this study, copper oxide (CuO) nanostructures were successfully prepared by adding EG (ethylene glycol) and PEG (4000, 8000) (polyethylene glycol) via an in-situ chemical precipitation method. EG and PEG (4000, 8000) were effective for changing the particular size of CuO and we examined the effects of drying type such as freeze drying, muffle and horizontal furnace on the size of CuO nanostructure. The structure, morphology and elemental analysis of CuO nanostructure were analyzed by field-emission scanning electron microscopy (FE-SEM), X-ray diffraction (XRD) and energy dispersive X-ray spectroscopy (EDS). Also, the CuO nanostructures showed excellent electrical conductivity by the changing of PEG’s molecular weight and drying processes.

Formulation Evaluation and Characterization of Fast Dissolving Tablets of Rofecoxib

2021 ◽  
pp. 60-64
Author(s):  
Preeti Mehra ◽  
Vishal Kapoor ◽  
Naveen Gupta ◽  
Dharmendra Singh Rajpoot ◽  
Neeraj Sharma
Keyword(s):  
Solid Dispersion ◽  
Water Solubility ◽  
Solid Dispersions ◽  
Amorphous State ◽  
Dissolution Profile ◽  
Major Drawback ◽  
Peg 4000 ◽  
Dissolution Efficiency ◽  
Pvp K30

Rofecoxib, a new non-steroidal anti-inflammatory agent mainly used for the treatment of osteoarthritis and rheumatoid arthritis. The major drawback of Rofecoxib is its very low water solubility, which results in poor bioavailability after oral administration. Hence, an attempt was made to formulate fast dissolving tablets of Rofecoxib. The solid dispersions of Rofecoxib were prepared with PEG-4000 and PVP K30 by solvent evaporation method. The characterization of prepared solid dispersions by FTIR, XRPD and DSC, which reveals lack of interaction with carriers and dictates amorphous state of solid dispersions. Solid dispersion of Rofecoxib with PVP K30 (1:6) showed maximum dissolution, therefore compressed into tablets by using microcrystalline cellulose, lactose and crosspovidone. The dissolution profile of developed fast dissolving tablets containing solid dispersion of Rofecoxib (1:6) was studied. The formulated formulations showed optimum dissolution efficiency.

Development and physicochemical characterization of saquinavir mesylate solid dispersions using Gelucire 44/14 or PEG 4000 as carrier

2013 ◽  
Vol 36 (9) ◽  
pp. 1113-1125 ◽  
Author(s):  
Thiago Caon ◽  
Ricardo Augusto Konig ◽  
Ariadne Cristiane Cabral da Cruz ◽  
Simone Gonçalves Cardoso ◽  
Carlos Eduardo Maduro Campos ◽  
...  
Keyword(s):  
Solid Dispersions ◽  
Physicochemical Characterization ◽  
Peg 4000

scholarly journals Expression, purification, crystallization and preliminary X-ray analysis of the PaaI-like thioesterase SAV0944 fromStaphylococcus aureus

2014 ◽  
Vol 70 (2) ◽  
pp. 244-247
Author(s):  
Yogesh B. Khandokar ◽  
Noelia Roman ◽  
Kate M. Smith ◽  
Parul Srivastava ◽  
Jade K. Forwood
Keyword(s):  
Recombinant Expression ◽  
Food Poisoning ◽  
Initial Structure ◽  
Molecular Replacement ◽  
Toxic Shock ◽  
Cellular Functions ◽  
Cell Parameters ◽  
Diffusion Technique ◽  
Peg 4000

Staphylococcus aureusis the causative agent of many diseases, including meningitis, bacteraemia, pneumonia, food poisoning and toxic shock syndrome. Structural characterization of the PaaI-like thioesterase SAV0944 (SaPaaI) fromS. aureussubsp.aureusMu50 will aid in understanding its potential as a new therapeutic target by knowledge of its molecular details and cellular functions. Here, the recombinant expression, purification and crystallization ofSaPaaI thioesterase fromS. aureusare reported. This protein initially crystallized with the ligand coenzyme A using the hanging-drop vapour-diffusion technique with condition No. 40 of Crystal Screen from Hampton Research at 296 K. Optimal final conditions consisting of 24% PEG 4000, 100 mMsodium citrate pH 6.5, 12% 2-propanol gave single diffraction-quality crystals. These crystals diffracted to beyond 2 Å resolution at the Australian Synchrotron and belonged to space groupP1211, with unit-cell parametersa= 44.05,b= 89.05,c= 60.74 Å, β = 100.5°. Initial structure determination and refinement gave anRfactor andRfreeof 17.3 and 22.0%, respectively, confirming a positive solution in obtaining phases using molecular replacement.

scholarly journals Trypanocidal Activity and Increased Solubility of Benznidazole Incorporated in PEG 4000 and Its Derivatives

2021 ◽  
Author(s):  
Lucas Sousa ◽  
Maria Luíza Azevedo ◽  
Dayana Rocha ◽  
Ângela Andrade ◽  
Tatiane Amparo ◽  
...  
Keyword(s):  
Polymeric Films ◽  
Dissolution Profile ◽  
Trypanocidal Activity ◽  
Force Microscopy ◽  
Atomic Force ◽  
Drug Concentrations ◽  
Peg 4000 ◽  
Lower Drug ◽  
The Stability

Selecting a polymer depends on its characteristics, the properties of the drug and of the remaining ingredients in the formulation. The drug, when incorporated into a polymeric matrix, can show several advantages when compared with its conventional form. In this context, this work describes the preparation and characterization of polyethylene glycol (PEG 4000) and its derivative particles loaded with benznidazole, as well as evaluates their trypanocidal activity. In this work, reactions to modify the PEG 4000 polymer and the subsequent incorporation of the benznidazole were made. The nuclear magnetic resonance (NMR) analysis confirmed the efficiency in modifying the PEG chains. The morphology of polymeric films was observed by atomic force microscopy (AFM) and showed considerable changes on the film organization. The acetylation of PEG favored the stability of the system and an increase in the zeta potential from -14.83 to -25.54 mV was observed. Although encapsulation efficiency values between 30.14 and 39.48% were found, the enhanced benznidazole dissolution profile by microparticles enables the use of lower drug concentrations. This fact can be proven by the increased trypanocidal effect of benznidazole when encapsulated in BP3 microparticles. Finally, the high selectivity of the formulations for trypanocidal action guarantees their safety as an alternative for the treatment of the Chagas disease.

scholarly journals Synthesis and characterization of sulfonated mesoporous NiO–ICG core–shell solid sphere catalyst with superior capability for methyl ester production

RSC Advances ◽  
2019 ◽  
Vol 9 (54) ◽  
pp. 31306-31315 ◽  
Author(s):  
Soroush Soltani ◽  
Nasrin Khanian ◽  
Umer Rashid ◽  
Thomas Shean Yaw Choong
Keyword(s):  
Polyethylene Glycol ◽  
Methyl Ester ◽  
Solid Sphere ◽  
Synthesis And Characterization ◽  
Core Shell ◽  
Peg 4000

In the present research, a mesoporous NiO core–shell solid sphere was hydrothermally synthesized, using polyethylene glycol (PEG; 4000) as a surfactant and incomplete carbonized glucose (ICG) as a template.

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