In vitro and in vivo antitumour activities of puerarin 6″-O-xyloside on human lung carcinoma A549 cell line via the induction of the mitochondria-mediated apoptosis pathway

2016 ◽  
Vol 54 (9) ◽  
pp. 1793-1799 ◽  
Author(s):  
Ti Chen ◽  
Hui Chen ◽  
Ying Wang ◽  
Jian Zhang
Keyword(s):  
Cell Line ◽  
Lung Carcinoma ◽  
A549 Cell ◽  
Human Lung ◽  
A549 Cell Line ◽  
Apoptosis Pathway ◽  
Human Lung Carcinoma

scholarly journals In Vitro and in Vivo Antitumor Activity of Scutebarbatine A on Human Lung Carcinoma A549 Cell Lines

Molecules ◽  
2014 ◽  
Vol 19 (7) ◽  
pp. 8740-8751 ◽  
Author(s):  
Xiao-Kun Yang ◽  
Ming-Yuan Xu ◽  
Gui-Sen Xu ◽  
Yu-Lan Zhang ◽  
Zhao-Xia Xu
Keyword(s):  
Antitumor Activity ◽  
Cell Lines ◽  
Lung Carcinoma ◽  
A549 Cell ◽  
Human Lung ◽  
In Vivo Antitumor Activity ◽  
Human Lung Carcinoma

Cytotoxicity of Imidazole Ionic Liquids in Human Lung Carcinoma A549 Cell Line

2014 ◽  
Vol 61 (7) ◽  
pp. 763-769 ◽  
Author(s):  
Hsiu-Liang Chen ◽  
Hui-Fang Kao ◽  
Jiu-Yao Wang ◽  
Guor-Tzo Wei
Keyword(s):  
Ionic Liquids ◽  
Cell Line ◽  
Lung Carcinoma ◽  
A549 Cell ◽  
Human Lung ◽  
A549 Cell Line ◽  
Human Lung Carcinoma

scholarly journals Synthesis, In Vitro Anticancer Activity and In Silico Study of some Benzylidene Hydrazide Derivatives

2020 ◽  
Vol 840 ◽  
pp. 277-283
Author(s):  
Melanny Ika Sulistyowaty ◽  
Galih Satrio Putra ◽  
Tutuk Budiati ◽  
Katsuyoshi Matsunami
Keyword(s):  
Cell Line ◽  
A549 Cell ◽  
In Silico ◽  
Protein Tyrosine Kinase ◽  
Human Lung ◽  
Human Lung Cancer ◽  
A549 Cell Line ◽  
Mtt Method ◽  
Lung Cancer A549 Cell

Some benzylidenehydrazides (3a-e) have been synthesized in three reaction steps from anthranilic acid in good yields, about 70% - 99%. The structures of the synthesized compounds were analyzed using spectroscopic methods. The compounds were evaluated its activity against human lung cancer, A549 cell line by MTT method and studied its molecular docking onto the protein tyrosine kinase (PDB ID: 1M17) by using Molegro® vs. 5.5. The data showed that N-(2-(2-(4-nitrobenzylidene)hydrazinecarbonyl)phenyl)benzamide (3d) which synthesized in 70% yield and has the highest activity on inhibiting the growth of A549 cell line with IC50 10.9μg/mL, which was linier with our in silico study. Compound 3d has the smallest RS value -94.44 kcal/mol, lower than selected Ligand, Erlotinib.

scholarly journals Efficacy of Combination Treatment and Influence of Schedule with Irinotecan and Amrubicin in Human Lung Carcinoma Cells in Vivo and in Vitro

2010 ◽  
Vol 33 (7) ◽  
pp. 1183-1191 ◽  
Author(s):  
Yoshiyuki Shishido ◽  
Tomio Furuta ◽  
Takeshi Matsuzaki ◽  
Hiroshi Nagata ◽  
Shusuke Hashimoto
Keyword(s):  
Lung Carcinoma ◽  
Combination Treatment ◽  
Human Lung ◽  
Carcinoma Cells ◽  
Lung Carcinoma Cells ◽  
Human Lung Carcinoma
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