Lesional mesial temporal epilepsy case discussions

Background: Multidisciplinary team (MDT) meetings provide treatment recommendations based on available information and collective decision-making in teams with complementary professions, disciplines and skills. We aimed to map ancillary medical and nonmedical patient information during case presentations and case discussions in MDT meetings in cancer care. Methods: Through a nonparticipant, observational approach, we mapped verbal information on medical, nonmedical and patient-related characteristics and classified these based on content. Data were collected from 336 case discussions in three MDTs for neuro-oncology, sarcoma and hepato-biliary cancer. Results: Information on physical status was presented in 48.2% of the case discussions, psychological status in 8.9% and comorbidity in 48.5% of the cases. Nonmedical factors, such as family relations, occupation, country of origin and abode were referred to in 3.6–7.7% of the cases, and patient preferences were reported in 4.2%. Conclusions: Provision of information on comorbidities in half of the cases and on patient characteristics and treatment preferences in <10% of case discussions suggest a need to define data elements and develop reporting standards to support robust MDT decision-making.

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Use of video vignettes and case discussions to educate health professions students about elder abuse

Journal of Interprofessional Education & Practice ◽

10.1016/j.xjep.2021.100434 ◽

2021 ◽

pp. 100434

Author(s):

Deepti Vyas ◽

Tracey DelNero ◽

Todd E. Davenport ◽

Gabriella Musacchia ◽

Lanchi Nguyen ◽

...

Keyword(s):

Elder Abuse ◽

Health Professions ◽

Case Discussions ◽

Video Vignettes

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Temporal epilepsy lesions may be detected by the voxel-based quantitative analysis of brain FDG-PET images using an original block-matching normalization software

Annals of Nuclear Medicine ◽

10.1007/s12149-016-1060-4 ◽

2016 ◽

Vol 30 (4) ◽

pp. 272-278 ◽

Cited By ~ 2

Author(s):

Antoine Verger ◽

Yalcin Yagdigul ◽

Axel Van Der Gucht ◽

Sylvain Poussier ◽

Eric Guedj ◽

...

Keyword(s):

Quantitative Analysis ◽

Fdg Pet ◽

Block Matching ◽

Temporal Epilepsy

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Changes in central 5-HT1A receptor binding in mesial temporal epilepsy measured by positron emission tomography with [11C]WAY100635

Epilepsy Research ◽

10.1016/j.eplepsyres.2006.09.003 ◽

2007 ◽

Vol 73 (1) ◽

pp. 111-118 ◽

Cited By ~ 12

Author(s):

Shigeo Ito ◽

Tetsuya Suhara ◽

Hiroshi Ito ◽

Fumihiko Yasuno ◽

Tetsuya Ichimiya ◽

...

Keyword(s):

Positron Emission Tomography ◽

Receptor Binding ◽

Emission Tomography ◽

Temporal Epilepsy ◽

Positron Emission

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THE INSULA: ISLAND OF REIL

Journal of Neurology Neurosurgery & Psychiatry ◽

10.1136/jnnp-2015-312379.63 ◽

2015 ◽

Vol 86 (11) ◽

pp. e4.155-e4

Author(s):

Ray Wynford-Thomas ◽

Rob Powell

Keyword(s):

Speech Processing ◽

Brain Function ◽

Insular Cortex ◽

Normal Brain ◽

Temporal Epilepsy ◽

Normal Brain Function ◽

Temporal Structures ◽

Hypermotor Seizures ◽

Posterior Insula ◽

As Effects

Just as ‘no man is an island’, despite its misleading name, the insula is not an island. Sitting deeply within the cerebrum, the insular cortex and its connections play an important role in both normal brain function and seizure generation. Stimulating specific areas of the insula can produce somatosensory, viscerosensory, somatomotor and visceroautonomic symptoms, as well as effects on speech processing and pain. Insular onset seizures are rare, but may mimic both temporal and extra-temporal epilepsy and if not recognised, may lead to failure of epilepsy surgery. We therefore highlight the semiology of insular epilepsy by discussing three cases with different auras. Insular onset seizures can broadly be divided into three main types both anatomically and according to seizure semiology:1. Seizures originating in the antero-inferior insula present with laryngeal constriction, along with visceral and gustatory auras (similar to those originating in medial temporal structures).2. Antero-superior onset seizures can have a silent onset, but tend to propagate rapidly to motor areas causing focal motor or hypermotor seizures.3. Seizures originating in the posterior insula present with contralateral sensory symptoms.

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38 Case Discussions on Surgical Decision Making for Massive Rotator Cuff Tears: Repair, Reconstruction, or Reverse Shoulder Replacement?

Video Atlas of Arthroscopic Rotator Cuff Repair ◽

10.1055/b-0041-179900 ◽

2021 ◽

Keyword(s):

Decision Making ◽

Rotator Cuff ◽

Rotator Cuff Tears ◽

Shoulder Replacement ◽

Surgical Decision ◽

Massive Rotator Cuff Tears ◽

Case Discussions ◽

Reverse Shoulder Replacement ◽

Surgical Decision Making

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Parameters of autonomic regulation in patients with focal frontal and temporal epilepsy

I P Pavlov Russian Medical Biological Herald ◽

10.23888/pavlovj202129145-53 ◽

2021 ◽

Vol 29 (1) ◽

pp. 45-53

Author(s):

Julia I. Medvedeva ◽

Roman A. Zorin ◽

Vladimir A. Zhadnov ◽

Michael M. Lapkin

Keyword(s):

Regression Analysis ◽

Temporal Lobe Epilepsy ◽

Evoked Potentials ◽

Temporal Lobe ◽

Focal Epilepsy ◽

Autonomic Regulation ◽

Control Group ◽

Temporal Epilepsy ◽

Logit Regression ◽

Autonomic Support

Aim. This study aimed to investigate the mechanisms of autonomic regulation and autonomic support in focal frontal and temporal lobe epilepsy. Materials and Methods. Thirty-six individuals were examined (19 men and 17 women; mean age 33.71.4 years) in the control group (without history of epileptic seizures) and 68 patients (32 men and 36 women, 34.11.5 years) with focal epilepsy (36 patients with frontal lobe epilepsy, of which 32 had temporal lobe epilepsy). Physiological parameters of heart rate variability and of skin sympathetic evoked potentials were evaluated. Results. Predomination of sympathetic influences in both groups of patients was found. According to the analysis of skin sympathetic evoked potentials, a high activity of the suprasegmental autonomic centers was determined in patients with epilepsy. Based on the results of the correlation analysis, the initial state in patients with temporal lobe epilepsy was characterized by greater intrasystemic tension that reflects the high level of physiological costs. The logit regression analysis model makes it possible to distribute patients with focal epilepsy into groups with different disease courses on the basis of the parameters of the autonomic support of the activity. Conclusion. In patients with focal epilepsy, predomination of sympathetic influences was observed, as well as greater activity of the suprasegmental centers of the autonomic regulation. Intrasystemic ratios of autonomic regulation parameters demonstrate an increase in the intrasystemic tension and a limitation of functional reserves in patients with temporal lobe epilepsy. A complex of parameters of autonomic support allows, based on the logit regression analysis, to distribute patients into groups with different courses of focal epilepsy.

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Elevated IL-6 and IL-1β are associated with temporal lobe epilepsy: A study in Chinese patients

European Journal of Inflammation ◽

10.1177/2058739218778934 ◽

2018 ◽

Vol 16 ◽

pp. 205873921877893 ◽

Cited By ~ 1

Author(s):

Li Xia ◽

Song-Qing Pan ◽

Qiu-Min Zhang ◽

Qin Zhou ◽

Lu Xia ◽

...

Keyword(s):

Temporal Lobe Epilepsy ◽

Temporal Lobe ◽

Chinese Patients ◽

Enzyme Linked Immunosorbent Assay ◽

Healthy Controls ◽

Temporal Epilepsy ◽

Tnf Α ◽

Plasma Cytokines ◽

Proinflammatory Molecules ◽

Positive Correlations

Activation of proinflammatory cytokines in seizures has been well characterized. However, role of cytokines in epilepsy and association with different clinical phenotype has not been well investigated. Reports on possible link between proinflammatory molecules and epilepsy are very limited. In this study, we performed a hospital-based case control study to investigate the association of plasma cytokines and their expression with different clinical categories of epilepsy. Patients admitted to Neurology Department of Renmin Hospital were enrolled in this study after clinical investigations. In all, 92 patients with temporal lobe epilepsy (TLE) and 45 with extra-temporal lobe epilepsy (XTLE) were included in this study. Furthermore, we included 86 healthy controls from the similar geographical population. Plasma levels of interleukin (IL)-6, tumor necrosis factor (TNF)-α, and IL-1β were quantified by enzyme-linked immunosorbent assay (ELISA). All plasma cytokines were elevated in TLE and XTLE compared to healthy controls ( P < 0.0001). Furthermore, IL-6 and IL-1β were significantly higher in TLE when compared to extra-temporal epilepsy. Incidentally, no difference in mean plasma TNF-α levels was noticed among TLE and XTLE. Positive correlations were observed between all plasma proinflammatory molecules (TNF-α, IL-6, and IL-1β) investigated in this study. Epilepsy patients displayed higher proinflammatory molecules, namely, IL-6, IL-1β, and TNF-α. Plasma IL-6 and IL-1β can be use as biomarkers for differentiation of TLE from XTLE.

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