Multislice computed tomography coronary plaque imaging

2007 ◽  
pp. 327-333
Author(s):  
Pim de Feyter ◽  
A Weustink ◽  
WB Meijboom ◽  
Nico Mollet ◽  
Filippo Cademartiri
Keyword(s):  
Computed Tomography ◽  
Multislice Computed Tomography ◽  
Coronary Plaque ◽  
Plaque Imaging

Coronary plaque imaging with multislice computed tomography: technique and clinical applications

2006 ◽  
Vol 16 (S7) ◽  
pp. M44-M53 ◽  
Author(s):  
Filippo Cademartiri ◽  
Ludovico La Grutta ◽  
Anselmo Alessandro Palumbo ◽  
Erica Maffei ◽  
Giuseppe Runza ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Multislice Computed Tomography ◽  
Coronary Plaque ◽  
Clinical Applications ◽  
Plaque Imaging

Abstract 2796: Coronary Plaque Classification by Multislice Computed Tomography in Comparison with Histopathological Examination of the Atheromatous Tissue Obtained by Directional Coronary Atherectomy

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Shigeki Kimura ◽  
Tsunekazu Kakuta ◽  
Taishi Yonetsu ◽  
Asami Suzuki ◽  
Yuki Komatsu ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Multislice Computed Tomography ◽  
Coronary Plaque ◽  
Plaque Morphology ◽  
Fibrous Plaque ◽  
Cutoff Value ◽  
Cutoff Values ◽  
Significant Difference ◽  
The Mean ◽  
Directional Coronary Atherectomy

Multislice computed tomography (MSCT) has been reported to characterize plaque morphology using intracoronary ultrasound (ICUS) findings as the reference. However, the histopathological assessment for the efficacy of MSCT to distinguish atherosclerotic coronary plaque components has not been performed in vivo. We sought to find the cutoff values of CT density (CTD) to classify the non-calcified plaques using histopathological findings as the standard of reference. Thirty nine target lesions treated by directional coronary atherectomy (DCA) in 39 patients with coronary artery disease, who underwent preintervention MSCT and ICUS, were investigated. The lesions with calcifications in MSCT were excluded. DCA samples of plaques were histopathologically classified into one of the two types; lipid rich plaque (L) or fibrous plaque (F), and further, these two plaque types were subdivided into each two groups, plaque with calcifications or without (L-C, L-NC, F-C, F-NC). The mean CTD was determined by ROI method (5 ROIs) from three cross-sections of each target lesion. We compared the mean CTD among the groups and determined the best cutoff values to differentiate plaque compositions by receiver operating characteristic (ROC) curve. Sixteen lesions were histopathologically classified as lipid rich (6 with calcification (L-C), 10 without (L-NC)) and 23 lesions as fibrous plaque (11: F-C, 12: F-NC). Although mean CTD was not significantly different among the groups (L-C: 73±28 HU, L-NC: 39±11, F-C: 87±15, F-NC: 70±12, p=0.09), there was a significant difference between L-NC and F-NC (p<0.01). ROC analysis revealed that the best cutoff value to differentiate L from F showed relatively low sensitivity (cutoff value 52HU, sensitivity 69%, specificity 96%, AUC 0.82), whereas very high sensitivity and specificity (cutoff value 44 HU, sensitivity 90%, specificity 100%, AUC 0.97) was detected for the cutoff value to differentiate L-NC from F-NC. Plaque CTD may accurately classify non-calcified plaque compositions comparable to histopathological definitions when the lesions were composed without microscopic calcifications.

scholarly journals Computed Tomography Coronary Plaque Imaging as a Secondary End Point for Randomized Pharmaceutical Trials

2010 ◽  
Vol 3 (3) ◽  
pp. 225-227
Author(s):  
Udo Hoffmann ◽  
Quynh A. Truong
Keyword(s):  
Computed Tomography ◽  
Coronary Plaque ◽  
Plaque Imaging ◽  
End Point

Coronary plaque burden detected by multislice computed tomography after acute myocardial infarction with near-normal coronary arteries by angiography

2003 ◽  
Vol 92 (7) ◽  
pp. 849-852 ◽  
Author(s):  
Christophe Caussin ◽  
Alice Ohanessian ◽  
Bernard Lancelin ◽  
Saliha Rahal ◽  
Remi Hennequin ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Computed Tomography ◽  
Acute Myocardial Infarction ◽  
Coronary Arteries ◽  
Multislice Computed Tomography ◽  
Coronary Plaque ◽  
Plaque Burden ◽  
Normal Coronary Arteries

Reproducible coronary plaque quantification by multislice computed tomography

2007 ◽  
Vol 69 (6) ◽  
pp. 857-865 ◽  
Author(s):  
Nico Bruining ◽  
Jos R.T.C. Roelandt ◽  
Alessandro Palumbo ◽  
Ludovico La Grutta ◽  
Filippo Cademartiri ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Multislice Computed Tomography ◽  
Coronary Plaque ◽  
Plaque Quantification

Noninvasive Assessment of Coronary Plaque Burden Using Multislice Computed Tomography

2005 ◽  
Vol 95 (10) ◽  
pp. 1165-1169 ◽  
Author(s):  
Nico R. Mollet ◽  
Filippo Cademartiri ◽  
Koen Nieman ◽  
Francesco Saia ◽  
Pedro A. Lemos ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Multislice Computed Tomography ◽  
Coronary Plaque ◽  
Plaque Burden ◽  
Noninvasive Assessment
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