We established multiple regression models by on-site survey on 3090 famers’ family in 139 counties in 4 provinces in the Huang-Huai plain, comprehensively analyzing the factors which affect the utilization of farmer's straw. Research results indicate that, some factors such as family agricultural labor population number, and family income level, and masters’ political conditions, and duties in village, and education life, and straw using technology master situation, and straw using cognitive and farming area, and farming system, and straw subsidies, and straw industry development have positive effects on straw comprehensive utilization, while the factors like part-time work degree, and domestic livestock culture situation, and the cost-effective of using straw have negative effects on straw comprehensive utilization. These factors like straw subsidies, the cost-effective of using straw, straw using cognitive, straw utilization technology, family farm income, farm area have significant impact on farmer's straw utilization; masters’ political conditions, duties in village, education life, family livestock culture situation, straw industry development make little influences. To increase the level of farmer's straw comprehensive utilization, there are some measures to take: Party members and leaders of the village further play the exemplary role apart from raising the awareness of farmers on crop straw; conscientiously implement the State subsidy policies about straw; implement straw utilization technology innovation, actively promote straw utilization technology; promote the realization of straw resources and commercialization to improve farmers’ income.