scholarly journals The death receptor Fas (CD95) is differentially expressed in brain metastases in breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Brain Metastases ◽  
Human Breast Cancer ◽  
Treatment Options ◽  
Death Receptor ◽  
Breast Cancer Patients ◽  
Human Breast ◽  
Primary Tumors ◽  
Microarray Datasets ◽  
The Brain

Breast cancer patients with metastasis to the brain are faced with limited treatment options (1). To facilitate enhanced understanding of the transcriptional makeup of brain metastasis in human breast cancer and to support discovery of novel therapeutic targets, we mined published microarray datasets (2, 3) to identify genes whose expression was most markedly different when comparing brain metastases to primary tumors from patients with breast cancer. We identified the Fas receptor as among the genes whose expression was most significantly different in metastases to the brain as compared to primary tumors of the breast. Decreased expression of Fas in brain metastases in patients with breast cancer may be important for any number of steps involved in metastasis, including colonization of the brain.

scholarly journals PPM1H is differentially expressed in brain metastases in breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Brain Metastases ◽  
Treatment Options ◽  
Normal Breast ◽  
Breast Cancer Patients ◽  
Human Breast ◽  
Gene Encoding ◽  
Primary Tumors ◽  
Microarray Datasets ◽  
The Brain

Breast cancer patients with metastasis to the brain are faced with limited treatment options (1). To facilitate enhanced understanding of the transcriptional makeup of brain metastasis in human breast cancer and to support discovery of novel therapeutic targets, we mined published microarray datasets (2, 3) to identify genes whose expression was most markedly different when comparing brain metastases to primary tumors from patients with breast cancer and to the normal breast. We identified the gene encoding the protein phosphatase PPM1H as among the genes whose expression was most significantly different in metastases to the brain as compared to primary tumors of the breast. Increased expression of PPM1H in brain metastases in patients with breast cancer may be important for any number of steps involved in metastasis, including colonization of the brain.

scholarly journals RNF186 is differentially expressed in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Treatment Options ◽  
Ring Finger ◽  
Metastatic Breast ◽  
Breast Cancer Patients ◽  
Human Breast ◽  
Primary Tumors ◽  
Endoplasmic Reticulum Stress Pathway ◽  
The Brain

Breast cancer patients diagnosed with metastasis to the brain (1-3) are presented limited treatment options (4, 5). We mined published microarray data (6, 7) to discover genes associated with brain metastasis in human breast cancer, and identified differential expression of RNF186 when comparing brain metastatic tissues to primary tumors of the breast. RNF186 was expressed at significantly lower levels in metastasis to the brain as compared to primary tumors. Molecular functions and down-regulation of RNF186, a ring finger E3 ligase that can modulate endoplasmic reticulum-stress pathway signaling (8) may be relevant to pathways underlying metastasis to the brain in human breast cancer.

scholarly journals LINC00968 is differentially expressed in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Human Breast Cancer ◽  
Treatment Options ◽  
Metastatic Breast ◽  
Breast Cancer Patients ◽  
Human Breast ◽  
Primary Tumors ◽  
Non Coding Rna ◽  
The Brain

Breast cancer patients diagnosed with metastasis to the brain (1-3) are presented limited treatment options (4, 5). We mined published microarray data (6, 7) to discover genes associated with brain metastasis in human breast cancer at the transcriptome-level and in an unbiased fashion. We describe here the differential expression of the long intergenic non-coding RNA LINC00968 in the brain metastatic tissues and primary tumors of women with breast cancer. LINC00968 transcript was present at significantly reduced quantities at in brain metastases and in primary tumors of the breast as compared to untransformed breast tissues. Molecular functions and down-regulation of LINC00968, a non-coding RNA that has not previously been described in relation to central nervous system metastasis in human breast cancer represents a feature of the transcriptional fingerprint of brain metastatic breast cancer in humans and may be relevant to pathways underlying invasion and colonization of the brain.

scholarly journals Asporin (ASPN) is differentially expressed in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Type I Collagen ◽  
Treatment Options ◽  
Metastatic Breast ◽  
Type I ◽  
Breast Cancer Patients ◽  
Human Breast ◽  
Primary Tumors ◽  
The Brain

Breast cancer patients diagnosed with metastasis to the brain (1-3) are presented limited treatment options (4, 5). We mined published microarray data (6, 7) to discover genes associated with brain metastasis in human breast cancer, and identified differential expression of the gene encoding asporin, ASPN, when comparing brain metastatic tissues to primary tumors of the breast. ASPN was expressed at significantly lower levels in metastasis to the brain as compared to primary tumors, and primary tumor expression of ASPN was significantly correlated with overall survival (8). Asporin (9) , its ability to interact with TGF-β (10) and type I collagen (11), and inhibition of these interactions through down-regulation of asporin expression may be relevant to pathways underlying metastasis to the brain in human breast cancer.

scholarly journals Palladin is differentially expressed in both lymph node and brain metastases in human breast cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Brain Metastases ◽  
Human Breast Cancer ◽  
Metastatic Breast ◽  
Metastatic Tumor ◽  
Clinical Problem ◽  
Human Breast ◽  
Primary Tumors ◽  
The Brain

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that palladin, encoded by PALLD, was among the genes whose expression was most quantitatively different in the brain metastases of patients with metastatic breast cancer. PALLD mRNA was present at decreased quantities in brain metastatic tissues as compared to primary tumors of the breast. Importantly, expression of PALLD in primary tumors was significantly correlated with patient overall survival in patients with breast cancer. Modulation of PALLD expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain.

scholarly journals Differential expression of the G0/G1 switch gene 2, G0S2, in the brain metastases of patients with breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Brain Metastases ◽  
Differential Expression ◽  
Treatment Options ◽  
Metastatic Breast ◽  
Significant Differential Expression ◽  
Primary Tumors ◽  
Breast Cancer Brain Metastasis ◽  
Microarray Datasets ◽  
The Brain

In patients with breast cancer, brain metastasis provides limited treatment options (1-3). To discover genes associated with brain metastases in patients with metastatic breast cancer, we mined published microarray datasets, comparing global transcription in brain metastases and primary tumors of the breast (4, 5). Using this methodology, we identified significant differential expression of the G0/G1 switch gene 2, encoded by G0S2, in the brain metastases of patients with breast cancer as compared to primary tumors of the breast. The G0S2 gene product could be of relevance to any one of the numerous processes by which tumor cells in breast cancer metastasize, including exit of the breast, entry into the periphery, breach of the blood brain barrier or colonization of and survival in the brain.

scholarly journals TPM4 is differentially expressed in both lymph node and brain metastases in human breast cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Brain Metastases ◽  
Human Breast Cancer ◽  
Metastatic Breast ◽  
Metastatic Tumor ◽  
Clinical Problem ◽  
Human Breast ◽  
Primary Tumors ◽  
The Brain

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that tropomyosin 4, encoded by TPM4, was among the genes whose expression was most quantitatively different in the brain metastases of patients with metastatic breast cancer. TPM4 mRNA was present at decreased quantities in brain metastatic tissues as compared to primary tumors of the breast. Importantly, expression of TPM4 in primary tumors was significantly correlated with patient overall survival in patients with breast cancer. Modulation of TPM4 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain.

scholarly journals TASP1 is differentially expressed in both lymph node and brain metastases in human breast cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Brain Metastases ◽  
Human Breast Cancer ◽  
Metastatic Breast ◽  
Metastatic Tumor ◽  
Clinical Problem ◽  
Human Breast ◽  
Primary Tumors ◽  
The Brain

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that taspase 1, encoded by TASP1, was among the genes whose expression was most quantitatively different in the brain metastases of patients with metastatic breast cancer. TASP1 mRNA was present at decreased quantities in brain metastatic tissues as compared to primary tumors of the breast. Importantly, expression of TASP1 in primary tumors was significantly correlated with patient overall survival in patients with breast cancer. Modulation of TASP1 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain.

scholarly journals The BRD8 bromodomain protein is differentially expressed in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Treatment Options ◽  
Metastatic Breast ◽  
Human Breast ◽  
Gene Encoding ◽  
Primary Tumors ◽  
Free Survival ◽  
Tumor Expression ◽  
The Brain

Metastasis to the brain is a serious complication of breast cancer (1-3) with limited treatment options (4, 5). We mined published microarray data (6, 7) to discover genes associated with brain metastasis in human breast cancer, and identified differential expression of the gene encoding the bromodomain protein BRD8 when comparing brain metastatic tissues to primary tumors of the breast. BRD8 was expressed at significantly lower levels in metastasis to the brain as compared to primary tumors, and primary tumor expression of BRD8 was significantly correlated with relapse-free survival. Understanding the transcriptional functions of BRD8 in the context of the Tip60/NuA4 histone acetyltransferase complex in human breast cancer may shed light on mechanisms that contribute to migration of tumor cells from the breast and subsequent colonization of the brain.

scholarly journals AKT1 is differentially expressed in primary tumors and brain metastases in humans with breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Brain Metastases ◽  
Metastatic Breast ◽  
Metastatic Tumor ◽  
Clinical Problem ◽  
Central Nervous System Metastasis ◽  
Human Breast ◽  
Primary Tumors ◽  
Breast Tissues ◽  
The Brain

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes to discover genes associated with brain metastasis in patients with metastatic breast cancer. We report here the differential expression of the protein kinase AKT1 in the primary tumors and brain metastases of humans with breast cancer. AKT1 mRNA was present at significantly increased quantities in brain metastatic tissues as compared to primary tumors of the breast. These data combined suggest that up-regulation of AKT1 is a conserved event, both during transformation of breast tissues and progression to central nervous system metastasis and further point to potential importance of AKT1 modulation during progression of human breast cancer.

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