scholarly journals PPM1H is differentially expressed in brain metastases in breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Brain Metastases ◽  
Treatment Options ◽  
Normal Breast ◽  
Breast Cancer Patients ◽  
Human Breast ◽  
Gene Encoding ◽  
Primary Tumors ◽  
Microarray Datasets ◽  
The Brain

Breast cancer patients with metastasis to the brain are faced with limited treatment options (1). To facilitate enhanced understanding of the transcriptional makeup of brain metastasis in human breast cancer and to support discovery of novel therapeutic targets, we mined published microarray datasets (2, 3) to identify genes whose expression was most markedly different when comparing brain metastases to primary tumors from patients with breast cancer and to the normal breast. We identified the gene encoding the protein phosphatase PPM1H as among the genes whose expression was most significantly different in metastases to the brain as compared to primary tumors of the breast. Increased expression of PPM1H in brain metastases in patients with breast cancer may be important for any number of steps involved in metastasis, including colonization of the brain.

scholarly journals The death receptor Fas (CD95) is differentially expressed in brain metastases in breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Brain Metastases ◽  
Human Breast Cancer ◽  
Treatment Options ◽  
Death Receptor ◽  
Breast Cancer Patients ◽  
Human Breast ◽  
Primary Tumors ◽  
Microarray Datasets ◽  
The Brain

Breast cancer patients with metastasis to the brain are faced with limited treatment options (1). To facilitate enhanced understanding of the transcriptional makeup of brain metastasis in human breast cancer and to support discovery of novel therapeutic targets, we mined published microarray datasets (2, 3) to identify genes whose expression was most markedly different when comparing brain metastases to primary tumors from patients with breast cancer. We identified the Fas receptor as among the genes whose expression was most significantly different in metastases to the brain as compared to primary tumors of the breast. Decreased expression of Fas in brain metastases in patients with breast cancer may be important for any number of steps involved in metastasis, including colonization of the brain.

scholarly journals Differential expression of the G0/G1 switch gene 2, G0S2, in the brain metastases of patients with breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Brain Metastases ◽  
Differential Expression ◽  
Treatment Options ◽  
Metastatic Breast ◽  
Significant Differential Expression ◽  
Primary Tumors ◽  
Breast Cancer Brain Metastasis ◽  
Microarray Datasets ◽  
The Brain

In patients with breast cancer, brain metastasis provides limited treatment options (1-3). To discover genes associated with brain metastases in patients with metastatic breast cancer, we mined published microarray datasets, comparing global transcription in brain metastases and primary tumors of the breast (4, 5). Using this methodology, we identified significant differential expression of the G0/G1 switch gene 2, encoded by G0S2, in the brain metastases of patients with breast cancer as compared to primary tumors of the breast. The G0S2 gene product could be of relevance to any one of the numerous processes by which tumor cells in breast cancer metastasize, including exit of the breast, entry into the periphery, breach of the blood brain barrier or colonization of and survival in the brain.

scholarly journals Differential expression of the oxytocin receptor, OXTR, in cancers of the breast.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Differential Expression ◽  
Oxytocin Receptor ◽  
Normal Breast ◽  
Breast Cancer Patients ◽  
Gene Encoding ◽  
Significant Differential Expression ◽  
Primary Tumors ◽  
Tumor Expression ◽  
Microarray Datasets

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2 , 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding the oxytocin receptor, OXTR, when comparing primary tumors of the breast to the tissue of origin, the normal breast. OXTR expression in primary tumors of the breast was significantly lower than in normal breast tissue, and relapse-free survival in breast cancer patients was significantly longer in patients with high tumor expression of OXTR than in patients with low tumor expression of OXTR. OXTR may be of relevance to initiation, maintenance or progression of cancers of the female breast.

scholarly journals RNF186 is differentially expressed in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Treatment Options ◽  
Ring Finger ◽  
Metastatic Breast ◽  
Breast Cancer Patients ◽  
Human Breast ◽  
Primary Tumors ◽  
Endoplasmic Reticulum Stress Pathway ◽  
The Brain

Breast cancer patients diagnosed with metastasis to the brain (1-3) are presented limited treatment options (4, 5). We mined published microarray data (6, 7) to discover genes associated with brain metastasis in human breast cancer, and identified differential expression of RNF186 when comparing brain metastatic tissues to primary tumors of the breast. RNF186 was expressed at significantly lower levels in metastasis to the brain as compared to primary tumors. Molecular functions and down-regulation of RNF186, a ring finger E3 ligase that can modulate endoplasmic reticulum-stress pathway signaling (8) may be relevant to pathways underlying metastasis to the brain in human breast cancer.

scholarly journals LINC00968 is differentially expressed in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Human Breast Cancer ◽  
Treatment Options ◽  
Metastatic Breast ◽  
Breast Cancer Patients ◽  
Human Breast ◽  
Primary Tumors ◽  
Non Coding Rna ◽  
The Brain

Breast cancer patients diagnosed with metastasis to the brain (1-3) are presented limited treatment options (4, 5). We mined published microarray data (6, 7) to discover genes associated with brain metastasis in human breast cancer at the transcriptome-level and in an unbiased fashion. We describe here the differential expression of the long intergenic non-coding RNA LINC00968 in the brain metastatic tissues and primary tumors of women with breast cancer. LINC00968 transcript was present at significantly reduced quantities at in brain metastases and in primary tumors of the breast as compared to untransformed breast tissues. Molecular functions and down-regulation of LINC00968, a non-coding RNA that has not previously been described in relation to central nervous system metastasis in human breast cancer represents a feature of the transcriptional fingerprint of brain metastatic breast cancer in humans and may be relevant to pathways underlying invasion and colonization of the brain.

scholarly journals Asporin (ASPN) is differentially expressed in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Type I Collagen ◽  
Treatment Options ◽  
Metastatic Breast ◽  
Type I ◽  
Breast Cancer Patients ◽  
Human Breast ◽  
Primary Tumors ◽  
The Brain

Breast cancer patients diagnosed with metastasis to the brain (1-3) are presented limited treatment options (4, 5). We mined published microarray data (6, 7) to discover genes associated with brain metastasis in human breast cancer, and identified differential expression of the gene encoding asporin, ASPN, when comparing brain metastatic tissues to primary tumors of the breast. ASPN was expressed at significantly lower levels in metastasis to the brain as compared to primary tumors, and primary tumor expression of ASPN was significantly correlated with overall survival (8). Asporin (9) , its ability to interact with TGF-β (10) and type I collagen (11), and inhibition of these interactions through down-regulation of asporin expression may be relevant to pathways underlying metastasis to the brain in human breast cancer.

scholarly journals Differential expression of LINC02716 in cancers of the breast.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Differential Expression ◽  
Metastatic Breast ◽  
Normal Breast ◽  
Differentially Expressed ◽  
Gene Encoding ◽  
Significant Differential Expression ◽  
Primary Tumors ◽  
Microarray Datasets ◽  
The Brain

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding LINC02716, DKFZp779M0652, when comparing primary tumors of the breast to the tissue of origin, the normal breast. DKFZp779M0652 was also differentially expressed in the brain metastases of patients with metastatic breast cancer. DKFZp779M0652 mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. DKFZp779M0652 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

scholarly journals Differential expression of the Wolf-Hirschhorn syndrome candidate 1, WHSC1 (NSD2/KMT3G), in cancers of the breast.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Differential Expression ◽  
Normal Breast ◽  
Breast Cancer Patients ◽  
Gene Encoding ◽  
Significant Differential Expression ◽  
Primary Tumors ◽  
Free Survival ◽  
Tumor Expression ◽  
Microarray Datasets

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding the H3K36 methyltransferase Wolf-Hirschhorn syndrome candidate 1, WHSC1, also known as Nsd2 or KMT3G, when comparing primary tumors of the breast to the tissue of origin, the normal breast. WHSC1 expression in primary tumors of the breast was significantly higher than in normal breast tissue, and relapse-free survival in breast cancer patients was significantly worse in patients with high tumor expression of WHSC1 than in patients with low tumor expression of WHSC1. WHSC1 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

scholarly journals CD300LG (Nepmucin) is differentially expressed in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Messenger Rna ◽  
Treatment Options ◽  
Metastatic Breast ◽  
Global Gene Expression ◽  
Normal Breast ◽  
Breast Cancer Patients ◽  
Primary Tumors ◽  
The Brain

Brain metastases affect up to 34% of breast cancer patients treated with trastuzumab (1). Limited treatment options are available for clinical control of brain metastatic breast cancer (2-4). We mined published microarray data (5, 6) to identify genes associated with metastasis to the brain in human breast cancer. This unbiased, global gene expression analysis identified differential expression of CD300LG as a transcriptional feature of brain metastasis in patients with breast cancer. Messenger RNA for CD300LG was present at significantly lower quantities in the brain metastatic tissues of patients with metastatic breast cancer. Additional microarray analysis revealed that CD300LG was also among the genes whose expression, transcriptome-wide, was most significantly different in primary tumors of the breast when compared to normal breast tissues. CD300LG is part of the transcriptional signature of human metastatic breast cancer.

scholarly journals The BRD8 bromodomain protein is differentially expressed in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Treatment Options ◽  
Metastatic Breast ◽  
Human Breast ◽  
Gene Encoding ◽  
Primary Tumors ◽  
Free Survival ◽  
Tumor Expression ◽  
The Brain

Metastasis to the brain is a serious complication of breast cancer (1-3) with limited treatment options (4, 5). We mined published microarray data (6, 7) to discover genes associated with brain metastasis in human breast cancer, and identified differential expression of the gene encoding the bromodomain protein BRD8 when comparing brain metastatic tissues to primary tumors of the breast. BRD8 was expressed at significantly lower levels in metastasis to the brain as compared to primary tumors, and primary tumor expression of BRD8 was significantly correlated with relapse-free survival. Understanding the transcriptional functions of BRD8 in the context of the Tip60/NuA4 histone acetyltransferase complex in human breast cancer may shed light on mechanisms that contribute to migration of tumor cells from the breast and subsequent colonization of the brain.

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