scholarly journals Differential expression of the G0/G1 switch gene 2, G0S2, in the brain metastases of patients with breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Brain Metastases ◽  
Differential Expression ◽  
Treatment Options ◽  
Metastatic Breast ◽  
Significant Differential Expression ◽  
Primary Tumors ◽  
Breast Cancer Brain Metastasis ◽  
Microarray Datasets ◽  
The Brain

In patients with breast cancer, brain metastasis provides limited treatment options (1-3). To discover genes associated with brain metastases in patients with metastatic breast cancer, we mined published microarray datasets, comparing global transcription in brain metastases and primary tumors of the breast (4, 5). Using this methodology, we identified significant differential expression of the G0/G1 switch gene 2, encoded by G0S2, in the brain metastases of patients with breast cancer as compared to primary tumors of the breast. The G0S2 gene product could be of relevance to any one of the numerous processes by which tumor cells in breast cancer metastasize, including exit of the breast, entry into the periphery, breach of the blood brain barrier or colonization of and survival in the brain.

scholarly journals Differential expression of growth-arrest specific 1, GAS1, in the brain metastases of patients with breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Brain Metastases ◽  
Differential Expression ◽  
Microarray Data ◽  
Treatment Options ◽  
Growth Arrest ◽  
Metastatic Breast ◽  
Significant Differential Expression ◽  
Primary Tumors ◽  
The Brain

Metastasis to the brain is a complication of breast cancer (1, 2) with limited treatment options (3). We mined published microarray data (4, 5) to discover genes associated with brain metastases in patients with metastatic breast cancer. We identified significant differential expression of GAS1 in the brain metastases of patients with breast cancer as compared to primary tumors of the breast. GAS1 may be relevant to the underlying biology by which tumor cells of the breast spread to the brain.

scholarly journals Differential expression of TNS1 in the brain metastases of patients with breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Brain Metastases ◽  
Differential Expression ◽  
Treatment Options ◽  
Metastatic Breast ◽  
Translation Initiation Factor ◽  
Initiation Factor ◽  
Significant Differential Expression ◽  
Primary Tumors ◽  
The Brain

Metastasis to the brain is a complication of breast cancer (1, 2) with limited treatment options (3). We mined published microarray data (4, 5) to discover genes associated with brain metastases in patients with metastatic breast cancer. We identified significant differential expression of the eukaryotic translation initiation factor TNS1 in the brain metastases of patients with breast cancer as compared to primary tumors of the breast. TNS1 may be relevant to the underlying biology by which tumor cells of the breast spread to the brain.

scholarly journals Differential expression of TAX1BP1 in the brain metastases of patients with breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Brain Metastases ◽  
Differential Expression ◽  
Treatment Options ◽  
Metastatic Breast ◽  
Significant Differential Expression ◽  
Interacting Protein ◽  
Primary Tumors ◽  
Tnf Α ◽  
The Brain

Metastasis to the brain is a complication of breast cancer (1, 2) with limited treatment options (3). We mined published microarray data (4, 5) to discover genes associated with brain metastases in patients with metastatic breast cancer. We identified significant differential expression TAX1BP1 in the brain metastases of patients with breast cancer as compared to primary tumors of the breast. TAX1BP1, an HLTV-I Tax-interacting protein with the ability to bind the deubiquitinase A20 and inhibit cell death mediated by Fas and TNF-α pathways (6-10), may be relevant to the underlying biology by which tumor cells of the breast spread to the brain.

scholarly journals Differential expression of VEGF-A in the brain and lymph node metastases of patients with breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Brain Metastases ◽  
Differential Expression ◽  
Lymph Node Metastases ◽  
Metastatic Breast ◽  
Significant Differential Expression ◽  
Primary Tumors ◽  
Node Metastases ◽  
The Brain

Metastasis to the brain is a complication of breast cancer (1, 2) with limited treatment options (3). We mined published microarray data (4, 5) to discover genes associated with brain metastases in patients with metastatic breast cancer. We identified significant differential expression of the gene encoding the vascular endothelial growth factor A, VEGFA, in both the brain metastases and lymph node metastases of patients with breast cancer as compared to primary tumors of the breast. VEGF-A, a molecule described to possess the ability to disrupt the blood-brain barrier (6), may be relevant to the underlying biology by which tumor cells of the breast spread to the lymph nodes and to the brain.

scholarly journals Differential expression of LINC02716 in cancers of the breast.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Differential Expression ◽  
Metastatic Breast ◽  
Normal Breast ◽  
Differentially Expressed ◽  
Gene Encoding ◽  
Significant Differential Expression ◽  
Primary Tumors ◽  
Microarray Datasets ◽  
The Brain

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding LINC02716, DKFZp779M0652, when comparing primary tumors of the breast to the tissue of origin, the normal breast. DKFZp779M0652 was also differentially expressed in the brain metastases of patients with metastatic breast cancer. DKFZp779M0652 mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. DKFZp779M0652 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

scholarly journals PPM1H is differentially expressed in brain metastases in breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Brain Metastases ◽  
Treatment Options ◽  
Normal Breast ◽  
Breast Cancer Patients ◽  
Human Breast ◽  
Gene Encoding ◽  
Primary Tumors ◽  
Microarray Datasets ◽  
The Brain

Breast cancer patients with metastasis to the brain are faced with limited treatment options (1). To facilitate enhanced understanding of the transcriptional makeup of brain metastasis in human breast cancer and to support discovery of novel therapeutic targets, we mined published microarray datasets (2, 3) to identify genes whose expression was most markedly different when comparing brain metastases to primary tumors from patients with breast cancer and to the normal breast. We identified the gene encoding the protein phosphatase PPM1H as among the genes whose expression was most significantly different in metastases to the brain as compared to primary tumors of the breast. Increased expression of PPM1H in brain metastases in patients with breast cancer may be important for any number of steps involved in metastasis, including colonization of the brain.

scholarly journals The death receptor Fas (CD95) is differentially expressed in brain metastases in breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Brain Metastases ◽  
Human Breast Cancer ◽  
Treatment Options ◽  
Death Receptor ◽  
Breast Cancer Patients ◽  
Human Breast ◽  
Primary Tumors ◽  
Microarray Datasets ◽  
The Brain

Breast cancer patients with metastasis to the brain are faced with limited treatment options (1). To facilitate enhanced understanding of the transcriptional makeup of brain metastasis in human breast cancer and to support discovery of novel therapeutic targets, we mined published microarray datasets (2, 3) to identify genes whose expression was most markedly different when comparing brain metastases to primary tumors from patients with breast cancer. We identified the Fas receptor as among the genes whose expression was most significantly different in metastases to the brain as compared to primary tumors of the breast. Decreased expression of Fas in brain metastases in patients with breast cancer may be important for any number of steps involved in metastasis, including colonization of the brain.

scholarly journals Cornifelin is differentially expressed in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Brain Metastasis ◽  
Brain Metastases ◽  
Differential Expression ◽  
Microarray Data ◽  
Metastatic Breast ◽  
Clinical Problem ◽  
Significant Differential Expression ◽  
The Brain

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to discover genes associated with brain metastasis in breast cancer. We identified significant differential expression of cornifelin, encoded by CNFN, in the brain metastases of patients with metastatic breast cancer. Increased expression of CNFN observed in brain metastatic tissues may be pertinent to understanding the biology underlying colonization of the brain with metastatic breast cancer clones.

scholarly journals Recurrent differential expression of open reading frames on chromosome 14 in human metastatic breast cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Differential Expression ◽  
Metastatic Breast ◽  
Open Reading Frames ◽  
Chromosome 14 ◽  
Primary Tumors ◽  
Microarray Datasets ◽  
The Brain ◽  
Reading Frames

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We leveraged the power of systems-level comparative transcriptome analysis in human tissues to discover genes associated with brain metastasis in human breast cancer by integration of multiple independent published microarray datasets (4-7). We identified five independent open reading frames on chromosome 14 that were among the most differentially expressed, transcriptome-wide, in the brain metastatic tissues of patients with metastatic breast cancer when compared to primary tumors of the breast: C14orf179, C14orf112, C14orf169, C14orf109 and C14orf130. Importantly, primary tumor expression of each of these open reading frames was significantly correlated with either overall, distant metastasis-free, or recurrence-free survival in patients with breast cancer. Analysis of three separate microarray datasets revealed at least five other open reading frames on chromosome 14 that were recurrently transcriptionally modulated in brain metastatic tissues of humans with metastatic breast cancer as evidenced by transcriptome-wide differential expression relative to primary tumors of the breast. It is possible that structural or epigenetic changes on chromosome 14 are a major feature associated with human brain metastatic breast cancer.

scholarly journals AKT1 is differentially expressed in primary tumors and brain metastases in humans with breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Brain Metastases ◽  
Metastatic Breast ◽  
Metastatic Tumor ◽  
Clinical Problem ◽  
Central Nervous System Metastasis ◽  
Human Breast ◽  
Primary Tumors ◽  
Breast Tissues ◽  
The Brain

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes to discover genes associated with brain metastasis in patients with metastatic breast cancer. We report here the differential expression of the protein kinase AKT1 in the primary tumors and brain metastases of humans with breast cancer. AKT1 mRNA was present at significantly increased quantities in brain metastatic tissues as compared to primary tumors of the breast. These data combined suggest that up-regulation of AKT1 is a conserved event, both during transformation of breast tissues and progression to central nervous system metastasis and further point to potential importance of AKT1 modulation during progression of human breast cancer.

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