scholarly journals The 17β-hydroxysteroid dehydrogenase type 4, HSD17B4, is differentially expressed in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Central Nervous System ◽  
Metastatic Breast Cancer ◽  
Microarray Data ◽  
Metastatic Breast ◽  
Hydroxysteroid Dehydrogenase ◽  
Breast Cancer Patients ◽  
Significant Differential Expression ◽  
Central Nervous System Metastases ◽  
The Brain

One study reported the incidence of central nervous system metastases in breast cancer patients treated with trastuzumab as 34% (1). We mined published microarray data (2, 3) to discover genes associated with brain metastasis in breast cancer. We identified significant differential expression of the 17β-hydroxysteroid dehydrogenase type 4, HSD17B4 (4-6), in patients with breast cancer. HSD17B4 may be relevant to the biology underlying colonization of the brain with metastatic breast cancer clones.

scholarly journals Glycoprotein M6A (GPM6A) is over-expressed in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Central Nervous System ◽  
Nervous System ◽  
Metastatic Breast Cancer ◽  
Microarray Data ◽  
Metastatic Breast ◽  
Breast Cancer Patients ◽  
Significant Differential Expression ◽  
Central Nervous System Metastases ◽  
The Brain

One study reported the incidence of central nervous system metastases in breast cancer patients treated with trastuzumab as 34% (1). We mined published microarray data (2, 3) to discover genes associated with brain metastasis in breast cancer. We identified significant differential expression of glycoprotein M6A, encoded by GPM6A (4, 5), in the brain metastases of patients with metastatic breast cancer. GPM6A may be relevant to the biology underlying colonization of the brain with metastatic breast cancer clones.

scholarly journals Auxilin (DNAJC6) is over-expressed in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Central Nervous System ◽  
Metastatic Breast Cancer ◽  
Microarray Data ◽  
Metastatic Breast ◽  
Coated Vesicle ◽  
Breast Cancer Patients ◽  
Significant Differential Expression ◽  
Central Nervous System Metastases ◽  
The Brain

One study reported the incidence of central nervous system metastases in breast cancer patients treated with trastuzumab as 34% (1). We mined published microarray data (2, 3) to discover genes associated with brain metastasis in breast cancer. We identified significant differential expression of auxilin, a molecule with the ability to support assembly and disassembly of the clathrin-coated vesicle lattice (4, 5), encoded by DNAJC6, in the brain metastases of patients with metastatic breast cancer. DNAJC6 may be relevant to the biology underlying colonization of the brain with metastatic breast cancer clones.

scholarly journals The L-type lectin LMAN2 is over-expressed in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Central Nervous System ◽  
Nervous System ◽  
Metastatic Breast Cancer ◽  
Microarray Data ◽  
Metastatic Breast ◽  
Breast Cancer Patients ◽  
Significant Differential Expression ◽  
Central Nervous System Metastases ◽  
The Brain

One study reported the incidence of central nervous system metastases in breast cancer patients treated with trastuzumab as 34% (1). We mined published microarray data (2, 3) to discover genes associated with brain metastasis in breast cancer. We identified significant differential expression of the L-type lectin LMAN2 (4-7), also known as VIP36, in patients with breast cancer. LMAN2 may be relevant to the biology underlying colonization of the brain with metastatic breast cancer clones.

scholarly journals Ma1 antigen (PNMA1) is over-expressed in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Central Nervous System ◽  
Nervous System ◽  
Metastatic Breast Cancer ◽  
Microarray Data ◽  
Metastatic Breast ◽  
Breast Cancer Patients ◽  
Significant Differential Expression ◽  
Central Nervous System Metastases ◽  
The Brain

One study reported the incidence of central nervous system metastases in breast cancer patients treated with trastuzumab as 34% (1). We mined published microarray data (2, 3) to discover genes associated with brain metastasis in breast cancer. We identified significant differential expression of the paraneoplastic Ma1 antigen, encoded by the PNMA1 gene, in the brain metastases of patients with breast cancer. PNMA1 may be relevant to the biology underlying colonization of the brain with metastatic breast cancer clones.

scholarly journals ZNF432 is over-expressed in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Central Nervous System ◽  
Nervous System ◽  
Metastatic Breast Cancer ◽  
Microarray Data ◽  
Metastatic Breast ◽  
Breast Cancer Patients ◽  
Significant Differential Expression ◽  
Central Nervous System Metastases ◽  
The Brain

One study reported the incidence of central nervous system metastases in breast cancer patients treated with trastuzumab as 34% (1). We mined published microarray data (2, 3) to discover genes associated with brain metastasis in breast cancer. We identified significant differential expression of ZNF432 in patients with breast cancer. ZNF432 may be relevant to the biology underlying colonization of the brain with metastatic breast cancer clones.

scholarly journals LRRC15 is differentially expressed in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Central Nervous System ◽  
Metastatic Breast Cancer ◽  
Microarray Data ◽  
Metastatic Breast ◽  
Leucine Rich Repeat ◽  
Breast Cancer Patients ◽  
Significant Differential Expression ◽  
Central Nervous System Metastases ◽  
The Brain

One study has reported a 34% incidence of central nervous system metastases, including metastasis to the brain, in breast cancer patients treated with trastuzumab (1). We mined published microarray data (2, 3) to discover genes associated with brain metastasis in breast cancer. We identified significant differential expression of the leucine-rich repeat-containing protein 15, encoded by LRRC15 (4, 5), in the brain metastases of patients with metastatic breast cancer. LRRC15 may be relevant to the biology underlying colonization of the brain with metastatic breast cancer clones.

scholarly journals Succinate dehydrogenase B (SDHB) is differentially expressed in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Succinate Dehydrogenase ◽  
Microarray Data ◽  
Metastatic Breast ◽  
Breast Cancer Patients ◽  
Mitochondrial Complex ◽  
Significant Differential Expression ◽  
Central Nervous System Metastases ◽  
The Brain

One study has reported a 34% incidence of central nervous system metastases, including metastasis to the brain, in breast cancer patients treated with trastuzumab (1). We mined published microarray data (2, 3) to discover genes associated with brain metastasis in breast cancer. We identified significant differential expression of the mitochondrial complex II subunit succinate dehydrogenase B, encoded by SDHB (4, 5), in the brain metastases of patients with metastatic breast cancer. SDHB may be relevant to the biology underlying colonization of the brain with metastatic breast cancer clones.

Central Nervous System Metastases in HER‐2–Positive Metastatic Breast Cancer Patients Treated with Trastuzumab: Incidence, Survival, and Risk Factors

2007 ◽  
Vol 12 (7) ◽  
pp. 766-773 ◽  
Author(s):  
Stefania Gori ◽  
Simonetta Rimondini ◽  
Verena De Angelis ◽  
Mariantonietta Colozza ◽  
Giancarlo Bisagni ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Central Nervous System ◽  
Nervous System ◽  
Metastatic Breast Cancer ◽  
Cancer Patients ◽  
Metastatic Breast ◽  
Breast Cancer Patients ◽  
Central Nervous System Metastases ◽  
Her 2

scholarly journals The beta subunit of the Interleukin-10 receptor is differentially expressed in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Brain Metastasis ◽  
Microarray Data ◽  
Metastatic Breast ◽  
Clinical Problem ◽  
Interleukin 10 ◽  
Beta Subunit ◽  
Significant Differential Expression ◽  
The Brain

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to discover genes associated with brain metastasis in breast cancer. We identified significant differential expression of the beta subunit of the interleukin-10 receptor, encoded by IL10RB, in the brain metastases of patients with metastatic breast cancer. Signals transduced from the interleukin-10 receptor, and its immunosuppressive and/or tolerogenic properties (6-10) may be relevant to the biology underlying colonization of the brain with metastatic breast cancer clones.

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