Ma1 antigen (PNMA1) is over-expressed in brain metastatic breast cancer.
Keyword(s):
One study reported the incidence of central nervous system metastases in breast cancer patients treated with trastuzumab as 34% (1). We mined published microarray data (2, 3) to discover genes associated with brain metastasis in breast cancer. We identified significant differential expression of the paraneoplastic Ma1 antigen, encoded by the PNMA1 gene, in the brain metastases of patients with breast cancer. PNMA1 may be relevant to the biology underlying colonization of the brain with metastatic breast cancer clones.
2020 ◽
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2020 ◽
2008 ◽
Vol 63
(2)
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pp. 275-280
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2008 ◽
Vol 6
(7)
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pp. 172-173