Auxilin (DNAJC6) is over-expressed in brain metastatic breast cancer.
Keyword(s):
One study reported the incidence of central nervous system metastases in breast cancer patients treated with trastuzumab as 34% (1). We mined published microarray data (2, 3) to discover genes associated with brain metastasis in breast cancer. We identified significant differential expression of auxilin, a molecule with the ability to support assembly and disassembly of the clathrin-coated vesicle lattice (4, 5), encoded by DNAJC6, in the brain metastases of patients with metastatic breast cancer. DNAJC6 may be relevant to the biology underlying colonization of the brain with metastatic breast cancer clones.
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2008 ◽
Vol 63
(2)
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pp. 275-280
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2020 ◽