scholarly journals Succinate dehydrogenase B (SDHB) is differentially expressed in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Succinate Dehydrogenase ◽  
Microarray Data ◽  
Metastatic Breast ◽  
Breast Cancer Patients ◽  
Mitochondrial Complex ◽  
Significant Differential Expression ◽  
Central Nervous System Metastases ◽  
The Brain

One study has reported a 34% incidence of central nervous system metastases, including metastasis to the brain, in breast cancer patients treated with trastuzumab (1). We mined published microarray data (2, 3) to discover genes associated with brain metastasis in breast cancer. We identified significant differential expression of the mitochondrial complex II subunit succinate dehydrogenase B, encoded by SDHB (4, 5), in the brain metastases of patients with metastatic breast cancer. SDHB may be relevant to the biology underlying colonization of the brain with metastatic breast cancer clones.

scholarly journals Glycoprotein M6A (GPM6A) is over-expressed in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Central Nervous System ◽  
Nervous System ◽  
Metastatic Breast Cancer ◽  
Microarray Data ◽  
Metastatic Breast ◽  
Breast Cancer Patients ◽  
Significant Differential Expression ◽  
Central Nervous System Metastases ◽  
The Brain

One study reported the incidence of central nervous system metastases in breast cancer patients treated with trastuzumab as 34% (1). We mined published microarray data (2, 3) to discover genes associated with brain metastasis in breast cancer. We identified significant differential expression of glycoprotein M6A, encoded by GPM6A (4, 5), in the brain metastases of patients with metastatic breast cancer. GPM6A may be relevant to the biology underlying colonization of the brain with metastatic breast cancer clones.

scholarly journals The 17β-hydroxysteroid dehydrogenase type 4, HSD17B4, is differentially expressed in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Central Nervous System ◽  
Metastatic Breast Cancer ◽  
Microarray Data ◽  
Metastatic Breast ◽  
Hydroxysteroid Dehydrogenase ◽  
Breast Cancer Patients ◽  
Significant Differential Expression ◽  
Central Nervous System Metastases ◽  
The Brain

One study reported the incidence of central nervous system metastases in breast cancer patients treated with trastuzumab as 34% (1). We mined published microarray data (2, 3) to discover genes associated with brain metastasis in breast cancer. We identified significant differential expression of the 17β-hydroxysteroid dehydrogenase type 4, HSD17B4 (4-6), in patients with breast cancer. HSD17B4 may be relevant to the biology underlying colonization of the brain with metastatic breast cancer clones.

scholarly journals Auxilin (DNAJC6) is over-expressed in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Central Nervous System ◽  
Metastatic Breast Cancer ◽  
Microarray Data ◽  
Metastatic Breast ◽  
Coated Vesicle ◽  
Breast Cancer Patients ◽  
Significant Differential Expression ◽  
Central Nervous System Metastases ◽  
The Brain

One study reported the incidence of central nervous system metastases in breast cancer patients treated with trastuzumab as 34% (1). We mined published microarray data (2, 3) to discover genes associated with brain metastasis in breast cancer. We identified significant differential expression of auxilin, a molecule with the ability to support assembly and disassembly of the clathrin-coated vesicle lattice (4, 5), encoded by DNAJC6, in the brain metastases of patients with metastatic breast cancer. DNAJC6 may be relevant to the biology underlying colonization of the brain with metastatic breast cancer clones.

scholarly journals The L-type lectin LMAN2 is over-expressed in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Central Nervous System ◽  
Nervous System ◽  
Metastatic Breast Cancer ◽  
Microarray Data ◽  
Metastatic Breast ◽  
Breast Cancer Patients ◽  
Significant Differential Expression ◽  
Central Nervous System Metastases ◽  
The Brain

One study reported the incidence of central nervous system metastases in breast cancer patients treated with trastuzumab as 34% (1). We mined published microarray data (2, 3) to discover genes associated with brain metastasis in breast cancer. We identified significant differential expression of the L-type lectin LMAN2 (4-7), also known as VIP36, in patients with breast cancer. LMAN2 may be relevant to the biology underlying colonization of the brain with metastatic breast cancer clones.

scholarly journals Ma1 antigen (PNMA1) is over-expressed in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Central Nervous System ◽  
Nervous System ◽  
Metastatic Breast Cancer ◽  
Microarray Data ◽  
Metastatic Breast ◽  
Breast Cancer Patients ◽  
Significant Differential Expression ◽  
Central Nervous System Metastases ◽  
The Brain

One study reported the incidence of central nervous system metastases in breast cancer patients treated with trastuzumab as 34% (1). We mined published microarray data (2, 3) to discover genes associated with brain metastasis in breast cancer. We identified significant differential expression of the paraneoplastic Ma1 antigen, encoded by the PNMA1 gene, in the brain metastases of patients with breast cancer. PNMA1 may be relevant to the biology underlying colonization of the brain with metastatic breast cancer clones.

scholarly journals ZNF432 is over-expressed in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Central Nervous System ◽  
Nervous System ◽  
Metastatic Breast Cancer ◽  
Microarray Data ◽  
Metastatic Breast ◽  
Breast Cancer Patients ◽  
Significant Differential Expression ◽  
Central Nervous System Metastases ◽  
The Brain

One study reported the incidence of central nervous system metastases in breast cancer patients treated with trastuzumab as 34% (1). We mined published microarray data (2, 3) to discover genes associated with brain metastasis in breast cancer. We identified significant differential expression of ZNF432 in patients with breast cancer. ZNF432 may be relevant to the biology underlying colonization of the brain with metastatic breast cancer clones.

scholarly journals LRRC15 is differentially expressed in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Central Nervous System ◽  
Metastatic Breast Cancer ◽  
Microarray Data ◽  
Metastatic Breast ◽  
Leucine Rich Repeat ◽  
Breast Cancer Patients ◽  
Significant Differential Expression ◽  
Central Nervous System Metastases ◽  
The Brain

One study has reported a 34% incidence of central nervous system metastases, including metastasis to the brain, in breast cancer patients treated with trastuzumab (1). We mined published microarray data (2, 3) to discover genes associated with brain metastasis in breast cancer. We identified significant differential expression of the leucine-rich repeat-containing protein 15, encoded by LRRC15 (4, 5), in the brain metastases of patients with metastatic breast cancer. LRRC15 may be relevant to the biology underlying colonization of the brain with metastatic breast cancer clones.

scholarly journals The beta subunit of the Interleukin-10 receptor is differentially expressed in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Brain Metastasis ◽  
Microarray Data ◽  
Metastatic Breast ◽  
Clinical Problem ◽  
Interleukin 10 ◽  
Beta Subunit ◽  
Significant Differential Expression ◽  
The Brain

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to discover genes associated with brain metastasis in breast cancer. We identified significant differential expression of the beta subunit of the interleukin-10 receptor, encoded by IL10RB, in the brain metastases of patients with metastatic breast cancer. Signals transduced from the interleukin-10 receptor, and its immunosuppressive and/or tolerogenic properties (6-10) may be relevant to the biology underlying colonization of the brain with metastatic breast cancer clones.

scholarly journals Cornifelin is differentially expressed in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Brain Metastasis ◽  
Brain Metastases ◽  
Differential Expression ◽  
Microarray Data ◽  
Metastatic Breast ◽  
Clinical Problem ◽  
Significant Differential Expression ◽  
The Brain

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to discover genes associated with brain metastasis in breast cancer. We identified significant differential expression of cornifelin, encoded by CNFN, in the brain metastases of patients with metastatic breast cancer. Increased expression of CNFN observed in brain metastatic tissues may be pertinent to understanding the biology underlying colonization of the brain with metastatic breast cancer clones.

scholarly journals The gastrin releasing peptide, GRP, is differentially expressed in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Brain Metastasis ◽  
Microarray Data ◽  
Metastatic Breast ◽  
Metastatic Tumor ◽  
Clinical Problem ◽  
Primary Tumors ◽  
Gastrin Releasing Peptide ◽  
The Brain

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes to discover genes associated with brain metastasis in patients with metastatic breast cancer. We found that the gastrin releasing peptide, encoded by GRP, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. Molecular functions of gastrin releasing peptide may be relevant to the processes by which tumor cells of the breast metastasize to the breast. Down-regulation of GRP may be an important event for metastasis of primary tumor-derived cancer cells to the brain in humans with metastatic breast cancer.

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