The L-type lectin LMAN2 is over-expressed in brain metastatic breast cancer.
Keyword(s):
One study reported the incidence of central nervous system metastases in breast cancer patients treated with trastuzumab as 34% (1). We mined published microarray data (2, 3) to discover genes associated with brain metastasis in breast cancer. We identified significant differential expression of the L-type lectin LMAN2 (4-7), also known as VIP36, in patients with breast cancer. LMAN2 may be relevant to the biology underlying colonization of the brain with metastatic breast cancer clones.
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2008 ◽
Vol 63
(2)
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pp. 275-280
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2008 ◽
Vol 6
(7)
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pp. 172-173