Mentalizing Imagery Therapy for depressed family dementia caregivers: Feasibility, clinical outcomes and brain connectivity changes

Background: Family dementia caregivers experience high rates of depression and anxiety that often go untreated due to time demands. We aimed to determine the feasibility of a brief, 4-week Mentalizing Imagery Therapy intervention, which couples mindfulness with guided imagery practices aimed at bolstering mentalizing capacity, to reduce caregiver psychological symptoms and to explore potential impact on dorsolateral prefrontal cortex connectivity.Methods: Twenty-four family dementia caregivers with moderate depression symptoms (a score of ≥10 in Patient Health Questionnaire-9) were assigned to either group Mentalizing Imagery Therapy (MIT, n=12) or a waitlist augmented by optional relaxation exercises (n=12). Participants completed questionnaires to measure depression and anxiety at baseline and follow-up, and those eligible also underwent resting state functional magnetic resonance (fMRI) brain imaging at these time points.Results: Eleven of 12 caregivers assigned to MIT completed the intervention and attended weekly groups 98% of the time. MIT home practice logs indicated average practice of 52 sessions per week for 238 minutes per session. All participants in waitlist completed the post-assessment. MIT participants exhibited significantly greater improvement than waitlist on self-reported depression and anxiety symptoms (p<.05) after 4 weeks. Neuroimaging results revealed increased dorsolateral prefrontal cortex connectivity with a putative emotion regulation network in the MIT group (p=.05) but not in waitlist (p=1.0).Limitations: Sample size limitations necessitate validation of findings in larger, randomized controlled trials. Conclusions: A 4-week group MIT program was feasible for caregivers, with high levels of participation in weekly group meetings and home practice exercises. This manuscript describes outcomes of a feasibility study of Mentalizing Imagery Therapy and is in review for peer reviewed publication as of 02.06.21.