scholarly journals Trajectories for mood states during a multi-session neurofeedback training intervention in major depressive disorder

2021 ◽  
Author(s):  
David Marc Anton Mehler ◽  
Stefanie Kunas ◽  
Moses O. Sokunbi ◽  
Rainer Göbel ◽  
David E.J. Linden
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Controlled Trial ◽  
Mood States ◽  
Control Group ◽  
Neurofeedback Training ◽  
Major Depressive ◽  
Total Mood Disturbance ◽  
Before And After ◽  
Randomised Controlled

Background: Non-invasive neurofeedback training is currently explored as a potential add-on therapy to treat patients suffering from major depressive disorder, and first trials show promising clin-ical effects. The temporal evolution of therapeutic change, however, remains unclear. Methods: Profile of mood states (POMS) questionnaire ratings were collected immediately before and after five sessions of real-time fMRI neurofeedback training (rt-fMRI-NFT) in a randomised controlled trial (RCT). Data were analysed for within and between treatment sessions ef-fects. Results: Trajectories of mood profiles varied between subscales. Total mood disturbance and the subscales depression and tension showed both within and between treatment sessions ef-fects, although within-session effects were descriptively larger. Limitations: The sample size was relatively small owed to the current state of the rt-fMRI-NFT field. No data from a sham-neurofeedback control group was available. Conclusions: The presented data provides a better understanding of when changes in mood states occur. The POMS questionnaire allows monitoring rapid and slowly evolving changes in mood states and can thus inform future study designs for neuromodulation and psychological in-terventions for mental disorders.

Acute and one-year outcome of a randomised controlled trial of brief cognitive therapy for major depressive disorder in primary care

1997 ◽  
Vol 171 (2) ◽  
pp. 131-134 ◽  
Author(s):  
Christine Scott ◽  
Mary Jane Tacchi ◽  
Roger Jones ◽  
Jan Scott
Keyword(s):  
Primary Care ◽  
Major Depressive Disorder ◽  
Randomised Controlled Trial ◽  
Depressive Disorder ◽  
Cognitive Therapy ◽  
Controlled Trial ◽  
Control Group ◽  
Major Depressive ◽  
Treatment As Usual ◽  
Randomised Controlled

BackgroundThe consensus statement on the treatment of depression (Paykel & Priest, 1992) advocates the use of cognitive therapy techniques as an adjunct to medication.MethodThis paper describes a randomised controlled trial of brief cognitive therapy (BCT) plus ‘treatment as usual’ versus treatment as usual in the management of 48 patients with major depressive disorder presenting in primary care.ResultsAt the end of the acute phase, significantly more subjects (P < 0.05) met recovery criteria in the intervention group (n=15) compared with the control group (n=8). When initial neuroticism scores were controlled for, reductions in Beck Depression Inventory and Hamilton Rating Scale for Depression scores favoured the BCT group throughout the 12 months of follow-up.ConclusionsBCT may be beneficial, but given the time constraints, therapists need to be more rather than less skilled in cognitive therapy. This, plus methodological limitations, leads us to advise caution before applying this approach more widely in primary care.

scholarly journals Employment and earnings trajectories before and after sickness absence due to major depressive disorder: a nationwide case–control study

2020 ◽  
pp. oemed-2020-106660
Author(s):  
Christian Hakulinen ◽  
Petri Böckerman ◽  
Laura Pulkki-Råback ◽  
Marianna Virtanen ◽  
Marko Elovainio
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Sickness Absence ◽  
Lower Probability ◽  
Control Group ◽  
Major Depressive ◽  
Earnings Losses ◽  
Before And After ◽  
History Of ◽  
And Gender

ObjectivesTo examine employment and earnings trajectories before and after the first sickness absence period due to major depressive disorder (MDD).MethodsAll individuals (n=158 813) in Finland who had a first sickness absence period (lasting longer than 9 days) due to MDD between 2005 and 2015 were matched with one randomly selected individual of the same age and gender with no history of MDD. Employment status and earnings were measured using register-based data annually from 2005 to 2015. Generalised estimating equations were used to examine the trajectories of employment and earnings before and after MDD diagnosis in men and women separately.ResultsSickness absence due to MDD was associated with increased probability of non-employment during and after the year of the first sickness absence period. In men, but not in women, the probability of being employed was lower 5 years before the sickness absence period due to MDD. When compared with the individuals in the control group, men had around 34% and women 15% lower earnings 1 year, and 40% and 23%, respectively, 5 years, after the first sickness absence period due to MDD. More severe MDD and longer duration of sickness absence period were associated with lower probability of being employed.ConclusionsSickness absence due to MDD was associated with considerable reduction in employment and earnings losses. For men and individuals with more severe MDD, this reduction was before the first sickness period. This supports a reciprocal association between employment and earnings with MDD.

scholarly journals Neurofeedback training in major depressive disorder: a systematic review of clinical efficacy, study quality and reporting practices

2020 ◽  
Author(s):  
Lucas Trambaiolli ◽  
Simon Huldreich Kohl ◽  
David E.J. Linden ◽  
David Marc Anton Mehler
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Clinical Efficacy ◽  
Dose Effect ◽  
Symptom Improvement ◽  
Control Group ◽  
Study Quality ◽  
Neurofeedback Training ◽  
Major Depressive ◽  
Reporting Practices

Major depressive disorder (MDD) is the leading cause of disability worldwide. Neurofeedback training has been suggested as a potential additional treatment option for MDD patients not reaching remission from standard care (i.e., psychopharmacology and psychotherapy). Here we systematically reviewed neurofeedback studies employing electroencephalography, or functional magnetic resonance-based protocols in depressive patients. Of 585 initially screened studies, 24 were included in our final sample (N=480 patients in experimental and N=194 in the control groups completing the primary endpoint). We evaluated the clinical efficacy across studies and explored its relationship with the number of sessions as a potential proxy for a dose-effect response. We also attempted to group studies according to the control condition categories currently used in the field that affect clinical outcomes in group comparisons. In most studies, MDD patients showed symptom improvement superior to the control group(s). However, most articles did not comply with the most stringent study quality and reporting practices. We conclude with recommendations on best practices for experimental designs and reporting standards for neurofeedback training.

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