scholarly journals Perspectives on targeting cardio-vascular diseases through reorientation of activities

2020 ◽  
Author(s):  
Atul Agarwal
Keyword(s):  
Cardiovascular Diseases ◽  
Acute Coronary Syndromes ◽  
Vascular Diseases ◽  
Peripheral Vascular ◽  
Primary And Secondary Prevention ◽  
Coronary Syndromes ◽  
New Perspective ◽  
Cardio Vascular ◽  
Underlying Pathology

Cardiovascular diseases include coronary artery, cerebrovascular, renovascular, and peripheral vascular diseases. These vascular diseases are known to present with many serious conditions―which include angina and acute coronary syndromes, strokes, cognitive impairment and dementia, epilepsy, parkinsonism, claudication, erectile dysfunction, renal failure, and hypertension. The underlying pathology for these ailments is atherosclerosis. Since 1950s, we have become increasingly focused on causation and management of cardiovascular diseases, which have strong behavioral components. Primary and secondary prevention remains our long-term goal. This paper discusses a new perspective on targeting cardiovascular diseases through reorientation of activities.

Antiplatelet Therapy in Acute Coronary Syndromes

2010 ◽  
Vol 6 (1) ◽  
pp. 58
Author(s):  
Sasha Koul ◽  
David Erlinge ◽  
◽  
Keyword(s):  
Platelet Function ◽  
Acute Coronary Syndromes ◽  
New Drugs ◽  
Antiplatelet Drugs ◽  
Bleeding Complications ◽  
Great Promise ◽  
Mortality Data ◽  
Poor Responders ◽  
Coronary Syndromes

Drugs inhibiting platelet function play a major role in the treatment of acute coronary syndromes (ACS). The first drug used, which is still considered the cornerstone of therapy today, is aspirin. Although very impressive in acutely decreasing rates of myocardial infarction as well as death, long-term data are scarce, despite our current recommendation for lifelong aspirin. The thienopyridines, most notably clopidogrel, are the next line of antiplatelet drugs. Well-documented data support the usage of clopidogrel for non-STEMI-ACS (NSTE-ACS). Although positive mortality data exist regarding clopidogrel and STEMI patients in a medically treated population, including thrombolysis, no larger amounts of randomised data exist in a primary PCI setting. Poor responders to aspirin and/or clopidogrel are a clinical problem, with these individuals constituting a higherrisk group for recurrent ischaemic events. Whereas very little can be done regarding aspirin resistance, clopidogrel resistance might be diminished by increasing the dosage or changing to more potent and newer-generation antiplatelet drugs. The role of glycoprotein IIb/IIIa inhibitors has diminished drastically and instead paved the way for thrombin antagonists (bivalirudin), which have fewer bleeding complications with resulting better long-term mortality. Novel adenosine diphosphate (ADP)-receptor blockers such as prasugrel and ticagrelor have shown increased efficacy over clopidogrel and hold great promise for the future. However, not all patients may benefit from these new drugs and economic constraints may also limit their use. Platelet function tests could possibly help in identifying risk groups in need of stronger platelet inhibition.

scholarly journals Recent Advances of Cell Membrane Coated Nanoparticles in Treating Cardiovascular Disorders

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3428
Author(s):  
Chaojie Zhu ◽  
Junkai Ma ◽  
Zhiheng Ji ◽  
Jie Shen ◽  
Qiwen Wang
Keyword(s):  
Cardiovascular Diseases ◽  
Cell Membrane ◽  
Preventive Therapy ◽  
Peripheral Vascular ◽  
Coating Technology ◽  
Immune Clearance ◽  
Coated Nanoparticles ◽  
Membrane Coating ◽  
Therapeutic Tools

Cardiovascular diseases (CVDs) are the leading cause of death worldwide, causing approximately 17.9 million deaths annually, an estimated 31% of all deaths, according to the WHO. CVDs are essentially rooted in atherosclerosis and are clinically classified into coronary heart disease, stroke and peripheral vascular disorders. Current clinical interventions include early diagnosis, the insertion of stents, and long-term preventive therapy. However, clinical diagnostic and therapeutic tools are subject to a number of limitations including, but not limited to, potential toxicity induced by contrast agents and unexpected bleeding caused by anti-platelet drugs. Nanomedicine has achieved great advancements in biomedical area. Among them, cell membrane coated nanoparticles, denoted as CMCNPs, have acquired enormous expectations due to their biomimetic properties. Such membrane coating technology not only helps avoid immune clearance, but also endows nanoparticles with diverse cellular and functional mimicry. In this review, we will describe the superiorities of CMCNPs in treating cardiovascular diseases and their potentials in optimizing current clinical managements.

scholarly journals Long-Term Mortality Benefits of Early Smoking Cessation after Acute Coronary Syndromes

2016 ◽  
Vol 25 ◽  
pp. S329
Author(s):  
M. Yudi ◽  
N. Andrianopoulos ◽  
O. Farouque ◽  
J. Ramchand ◽  
N. Jones ◽  
...  
Keyword(s):  
Smoking Cessation ◽  
Acute Coronary Syndromes ◽  
Coronary Syndromes ◽  
Long Term Mortality

scholarly journals Antiartherosclerotic Effects of Plant Flavonoids

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Shamala Salvamani ◽  
Baskaran Gunasekaran ◽  
Noor Azmi Shaharuddin ◽  
Siti Aqlima Ahmad ◽  
Mohd Yunus Shukor
Keyword(s):  
Cardiovascular Diseases ◽  
Side Effects ◽  
Animal Models ◽  
Vascular Diseases ◽  
Lipid Lowering ◽  
Peripheral Vascular ◽  
Heart Attacks ◽  
Synthetic Drug

Atherosclerosis is the process of hardening and narrowing the arteries. Atherosclerosis is generally associated with cardiovascular diseases such as strokes, heart attacks, and peripheral vascular diseases. Since the usage of the synthetic drug, statins, leads to various side effects, the plants flavonoids with antiartherosclerotic activity gained much attention and were proven to reduce the risk of atherosclerosisin vitroandin vivobased on different animal models. The flavonoids compounds also exhibit lipid lowering effects and anti-inflammatory and antiatherogenic properties. The future development of flavonoids-based drugs is believed to provide significant effects on atherosclerosis and its related diseases. This paper discusses the antiatherosclerotic effects of selected plant flavonoids such as quercetin, kaempferol, myricetin, rutin, naringenin, catechin, fisetin, and gossypetin.

Association Between Blood Glucose and Long-Term Mortality in Patients With Acute Coronary Syndromes in the OPUS-TIMI 16 Trial

2006 ◽  
Vol 97 (11) ◽  
pp. 1573-1577 ◽  
Author(s):  
Satish Bhadriraju ◽  
Kausik K. Ray ◽  
Anthony C. DeFranco ◽  
Kim Barber ◽  
Padmini Bhadriraju ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Acute Coronary Syndromes ◽  
Coronary Syndromes ◽  
Long Term Mortality

Prevalence, long-term prognosis and medical alternatives for patients admitted for acute coronary syndromes and prasugrel contraindication

2018 ◽  
Vol 270 ◽  
pp. 36-41 ◽  
Author(s):  
Alberto Cordero ◽  
Jose M. García-Acuña ◽  
Moisés Rodríguez-Mañero ◽  
Rosa Agra-Bermejo ◽  
Belen Cid ◽  
...  
Keyword(s):  
Acute Coronary Syndromes ◽  
Coronary Syndromes ◽  
Long Term Prognosis
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