scholarly journals Reward sensitivity and internalizing symptoms during the transition to puberty: An examination of 9-and 10-year-olds in the ABCD Study

2021 ◽  
Author(s):  
Elizabeth A. McNeilly ◽  
Natalie Marie Saragosa-Harris ◽  
Kathryn L. Mills ◽  
Ronald Dahl ◽  
Lucía Magis-Weinberg
Keyword(s):  
Internalizing Symptoms ◽  
Pubertal Timing ◽  
Internalizing Disorders ◽  
Preliminary Evidence ◽  
Reward Sensitivity ◽  
Increased Risk ◽  
Early Pubertal Timing ◽  
Adolescents And Adults ◽  
Window Of Vulnerability

Early pubertal timing has been linked to increased risk for internalizing disorders. Work in older adolescents and adults suggests that heightened reward sensitivity may buffer risk for internalizing symptoms, but few studies have investigated these associations during the early transition to puberty, a window of vulnerability to mental health risk. In this preregistered study, we investigated the associations among pubertal timing, internalizing symptoms, and reward sensitivity in 11,243 9-10 year-olds from the Adolescent Brain Cognitive Development (ABCD) Study®. Using split-half analysis, we tested hypothesized effects across two subsets of the sample (Sample 1 N=5,631 ; Sample 2 N=5,612). Across samples, early pubertal timing was associated with higher internalizing symptoms in females and males, with highest symptoms evident in mid-pubertal adolescents. Additionally, early pubertal timing was robustly associated with greater self-reported reward sensitivity in both females and males. We observed preliminary evidence of a moderating role of self-reported and neural reward sensitivity in the association between early pubertal timing and internalizing symptoms, but several of these effects differed by sex, and no moderation effects replicated across samples. Together, these findings provide novel insights into early indicators of risk for internalizing disorders during the transition to puberty.

scholarly journals The Potential Utility for Massage Therapy During Pregnancy to Decrease Stress and Tobacco Use

2018 ◽  
Vol 11 (3) ◽  
pp. 15-19 ◽  
Author(s):  
Cayla M. O’Hair, BA ◽  
Kathryn Armstrong, MA, LMT ◽  
Helena J.V. Rutherford, PhD
Keyword(s):  
Tobacco Use ◽  
Tobacco Cessation ◽  
Infant Development ◽  
Massage Therapy ◽  
Preliminary Evidence ◽  
Effective Interventions ◽  
Increased Risk ◽  
Traditional Counseling ◽  
Smoke Tobacco

Background: A significant number of women continue to smoke tobacco during pregnancy despite the increased risk of complications to fetal and infant development. Therefore, effective interventions are needed to assist pregnant women with the process of tobacco cessation. Traditional counseling programs have demonstrated some success; however, novel approaches that target stressas a mechanism in the maintenance of addiction would be valuable.Objective: To examine the role of stress in addiction and the utility of massage therapy to decrease stress during pregnancy.Conclusion: Preliminary evidence suggests massage therapy may be beneficial to decreasing tobacco use, and research in pregnant populations is needed.

scholarly journals The role of pubertal timing and temperamental vulnerability in adolescents' internalizing symptoms

2013 ◽  
Vol 25 (2) ◽  
pp. 377-389 ◽  
Author(s):  
Lisa J. Crockett ◽  
Gustavo Carlo ◽  
Jennifer M. Wolff ◽  
Meredith O. Hope
Keyword(s):  
Internalizing Symptoms ◽  
Structural Equation ◽  
Emotional Reactivity ◽  
Structural Equation Models ◽  
Pubertal Timing ◽  
Pubertal Development ◽  
Self Regulation ◽  
Internalizing Behavior ◽  
Adolescent Girls And Boys

AbstractThis longitudinal study examined the joint role of pubertal timing and temperament variables (emotional reactivity and self-regulation) in predicting adolescents' internalizing symptoms. The multiethnic sample included 1,025 adolescent girls and boys followed from age 11 to age 15 (M age = 11.03 years at Time 1). In structural equation models, age 11 measures of pubertal timing, emotional reactivity, and self-regulation and their interactions were used to predict adolescents' internalizing behavior concurrently and at age 15. Results indicated that, among girls, early pubertal timing, higher emotional reactivity, and lower self-regulation predicted increased internalizing behavior. In addition, self-regulation moderated the effect of pubertal timing such that effects of earlier timing on subsequent internalizing were seen primarily among girls with relatively poor self-regulation. Among boys, higher levels of emotional reactivity and lower self-regulation predicted increased internalizing, but there were no effects of pubertal timing. After controlling for Time 1 internalizing symptoms, only self-regulation predicted change in internalizing symptoms. Discussion focuses on the possible interplay of temperament and pubertal development in predicting internalizing problems during adolescence.

Environmental and genetic pathways between early pubertal timing and dieting in adolescence: distinguishing between objective and subjective timing

2011 ◽  
Vol 42 (1) ◽  
pp. 183-193 ◽  
Author(s):  
K. P. Harden ◽  
J. Mendle ◽  
N. Kretsch
Keyword(s):  
Eating Behaviors ◽  
Pubertal Timing ◽  
Pubertal Development ◽  
Objective Measures ◽  
Disordered Eating Behaviors ◽  
Subjective Perceptions ◽  
Menarcheal Age ◽  
Increased Risk ◽  
Early Pubertal Timing ◽  
Increase Risk

BackgroundEarly pubertal timing in girls is associated with elevated risk for dieting and eating pathology. The relative importance of biological versus socio-environmental mechanisms in explaining this association remains unclear. Moreover, these mechanisms may differ between objective measures of pubertal development and girls' subjective perceptions of their own maturation.MethodThe sample comprised 924 sister pairs from the National Longitudinal Study of Adolescent Health. Objective pubertal timing (menarcheal age), girls' perceptions of pubertal status and timing relative to peers, dieting and disordered eating behaviors were assessed during a series of confidential in-home interviews.ResultsBehavioral genetic models indicated that common genetic influences accounted for the association between early menarcheal age and increased risk for dieting in adolescence. In contrast, girls' subjective perceptions of their timing relative to peers were associated with dieting through an environmental pathway. Overall, subjective and objective measures of pubertal timing accounted for 12% of the variance in dieting.ConclusionsGenetic differences in menarcheal age increase risk for dieting among adolescent girls, while girls' perceptions of their maturation represent an environmentally mediated risk.

scholarly journals The Role of Pubertal Timing in the Development of Peer Victimization and Offending From Early- to Mid-Adolescence

2021 ◽  
pp. 027243162110022
Author(s):  
Therése Skoog ◽  
Sabina Kapetanovic
Keyword(s):  
Peer Victimization ◽  
Peer Relations ◽  
Negative Impact ◽  
Developmental Trajectories ◽  
Pubertal Timing ◽  
Growth Curve Analysis ◽  
Early Puberty ◽  
Early Pubertal Timing ◽  
Latent Growth Curve Analysis

We used latent growth curve analysis to extend research on associations between early puberty and adverse peer relations by examining the role of pubertal timing in the developmental trajectories of peer victimization and offending from early- to mid-adolescence. We made use of three-wave longitudinal data collected annually from a cohort of Swedish adolescents ( N = 1,515, 51% girls, [Formula: see text]age at T1 = 13.0 years). The results revealed negative developmental trends for peer victimization and offending. Early pubertal timing was linked to higher initial levels and a steeper decrease of peer victimization and offending. The only effect of pubertal timing that differed between the genders was that the initial level of offending was stronger for boys than girls. In conclusion, the negative impact of early pubertal timing on peer victimization and offending occurs in the early stages of adolescence and disappears thereafter.

scholarly journals Parenting Styles as a Moderator of the Association between Pubertal Timing and Chinese Adolescents’ Smoking Behavior

2021 ◽  
Vol 18 (17) ◽  
pp. 8903
Author(s):  
Hui Ling ◽  
Yaqin Yan ◽  
En Fu ◽  
Amin Zhu ◽  
Jianren Zhang ◽  
...  
Keyword(s):  
Parenting Style ◽  
Pubertal Timing ◽  
Smoking Behavior ◽  
Adolescent Smoking ◽  
Chinese Adolescents ◽  
Chinese Version ◽  
Negative Outcomes ◽  
Early Pubertal Timing ◽  
The Relationship

Background: Pubertal timing refers to the timing of an individual regarding pubertal sexual maturation, both physiologically and psychologically. Existing research shows that pubertal timing is associated with behavioral problems. This study investigated the role of parenting style in the relationship between pubertal timing and Chinese adolescents’ smoking behavior. Methods: The study examined the association of pubertal timing, parenting style and adolescents’ smoking behavior, using the Pubertal Development Scale (Chinese version), Simplified Parenting Style Scale-Chinese version, and three items related to adolescents’ smoking situation. Participants were 1391 Chinese adolescents aged 11–16 years old (53.41% boys). Hierarchical linear regression analyses assessed the moderating role of parenting style on the association between pubertal timing and adolescent smoking behavior. Results: The results indicated that parenting style moderates the relationship between pubertal timing and adolescent smoking behavior. For male adolescents, father rejection moderated the relationship between early pubertal timing and smoking behavior. For female adolescents, father rejection, father emotional warmth, and mother emotional warmth moderated the relationship between pubertal timing and smoking behavior. Conclusions: Findings from the study highlight the importance of parenting style, which may influence the negative outcomes associated with early pubertal timing and can help improve interventions aimed at reducing these negative outcomes.

scholarly journals Assessing the relationship between monoallelic PRKN mutations and Parkinson’s risk

2021 ◽  
Author(s):  
Steven J Lubbe ◽  
Bernabe I Bustos ◽  
Jing Hu ◽  
Dimitri Krainc ◽  
Theresita Joseph ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Copy Number Variant ◽  
Fold Increase ◽  
Preliminary Evidence ◽  
P Value ◽  
Biallelic Mutation ◽  
Mutation Status ◽  
Increased Risk ◽  
Biallelic Mutations

Abstract Biallelic Parkin (PRKN) mutations cause autosomal recessive Parkinson’s disease (PD); however, the role of monoallelic PRKN mutations as a risk factor for PD remains unclear. We investigated the role of single heterozygous PRKN mutations in three large independent case-control cohorts totalling 10 858 PD cases and 8328 controls. Overall, after exclusion of biallelic carriers, single PRKN mutations were more common in PD than controls conferring a >1.5-fold increase in the risk of PD [P-value (P) = 0.035], with meta-analysis (19 574 PD cases and 468 488 controls) confirming increased risk [Odds ratio (OR) = 1.65, P = 3.69E-07]. Carriers were shown to have significantly younger ages at the onset compared with non-carriers (NeuroX: 56.4 vs. 61.4 years; exome: 38.5 vs. 43.1 years). Stratifying by mutation type, we provide preliminary evidence for a more pathogenic risk profile for single PRKN copy number variant (CNV) carriers compared with single nucleotide variant carriers. Studies that did not assess biallelic PRKN mutations or consist of predominantly early-onset cases may be biasing these estimates, and removal of these resulted in a loss of association (OR = 1.23, P = 0.614; n = 4). Importantly, when we looked for additional CNVs in 30% of PD cases with apparent monoallellic PRKN mutations, we found that 44% had biallelic mutations, suggesting that previous estimates may be influenced by cryptic biallelic mutation status. While this study supports the association of single PRKN mutations with PD, it highlights confounding effects; therefore, caution is needed when interpreting current risk estimates. Together, we demonstrate that comprehensive assessment of biallelic mutation status is essential when elucidating PD risk associated with monoallelic PRKN mutations.

scholarly journals Childhood adversity, pubertal timing and self-harm: a longitudinal cohort study

2021 ◽  
pp. 1-9
Author(s):  
Abigail Emma Russell ◽  
Carol Joinson ◽  
Elystan Roberts ◽  
Jon Heron ◽  
Tamsin Ford ◽  
...  
Keyword(s):  
Structural Equation ◽  
Pubertal Timing ◽  
Childhood Adversity ◽  
Height Velocity ◽  
Age At Menarche ◽  
Peak Height Velocity ◽  
Early Puberty ◽  
Increased Risk ◽  
Early Pubertal Timing ◽  
Self Harm

Abstract Background The occurrence of early childhood adversity is strongly linked to later self-harm, but there is poor understanding of how this distal risk factor might influence later behaviours. One possible mechanism is through an earlier onset of puberty in children exposed to adversity, since early puberty is associated with an increased risk of adolescent self-harm. We investigated whether early pubertal timing mediates the association between childhood adversity and later self-harm. Methods Participants were 6698 young people from a UK population-based birth cohort (ALSPAC). We measured exposure to nine types of adversity from 0 to 9 years old, and self-harm when participants were aged 16 and 21 years. Pubertal timing measures were age at peak height velocity (aPHV – males and females) and age at menarche (AAM). We used generalised structural equation modelling for analyses. Results For every additional type of adversity; participants had an average 12–14% increased risk of self-harm by 16. Relative risk (RR) estimates were stronger for direct effects when outcomes were self-harm with suicidal intent. There was no evidence that earlier pubertal timing mediated the association between adversity and self-harm [indirect effect RR 1.00, 95% confidence interval (CI) 1.00–1.00 for aPHV and RR 1.00, 95% CI 1.00–1.01 for AAM]. Conclusions A cumulative measure of exposure to multiple types of adversity does not confer an increased risk of self-harm via early pubertal timing, however both childhood adversity and early puberty are risk factors for later self-harm. Research identifying mechanisms underlying the link between childhood adversity and later self-harm is needed to inform interventions.

scholarly journals The Role of Pubertal Timing and Heterosocial Involvement in Early Adolescents’ Media Internalization: A Moderated Moderation Analysis

2020 ◽  
Vol 40 (8) ◽  
pp. 1167-1194
Author(s):  
Ann Rousseau ◽  
Helene Laporte ◽  
Felix Grundmann ◽  
Steven Eggermont
Keyword(s):  
Peer Interactions ◽  
Pubertal Timing ◽  
Panel Study ◽  
Early Adolescents ◽  
Negative Influence ◽  
Protective Role ◽  
Developmental Factors ◽  
Early Pubertal Timing ◽  
Media Internalization

The present three-wave panel study ( N = 968, [Formula: see text] = 11.30, SD = 1.06) examines how developmental factors—pubertal timing and heterosocial involvement (i.e., one’s involvement in cross-sex activities)—influence early adolescents’ level of media internalization. We hypothesized that early pubertal timing positively moderates the association between sexualizing magazine reading and media internalization. Next, we argued that increased heterosocial involvement will weaken the amplifying influence of early pubertal timing on the aforementioned relationship. Both hypotheses were confirmed. For early adolescents who mature earlier than same-age/sex peers, reading sexualizing magazines resulted in more media internalization. Furthermore, our results showed that moderate to high cross-sex peer interactions can serve as a protective force against the negative influence of early pubertal timing. These results highlight the influential role of appearance-related developmental factors in the processing of sexualizing magazine content and point to the potential protective role of cross-sex peer interactions in media internalization.

scholarly journals ASSESSING THE RELATIONSHIP BETWEEN MONOALLELIC PARK2 MUTATIONS AND PARKINSON’S RISK

2020 ◽  
Author(s):  
Steven J Lubbe ◽  
Bernabe Bustos ◽  
Jing Hu ◽  
Dimitri Krainc ◽  
Theresita Joseph ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Copy Number Variant ◽  
Fold Increase ◽  
Preliminary Evidence ◽  
Biallelic Mutation ◽  
Mutation Status ◽  
Increased Risk ◽  
Independent Case ◽  
Biallelic Mutations

ABSTRACTBiallelic PARK2 (Parkin) mutations cause autosomal recessive Parkinson’s (PD); however, the role of monoallelic PARK2 mutations as a risk factor for PD remains unclear. We investigated the role of single heterozygous PARK2 mutations in three large independent case-control cohorts totalling 10,858 PD cases and 8,328 controls. Overall, after exclusion of biallelic carriers, single PARK2 mutations were more common in PD than controls conferring a >1.5-fold increase in risk of PD (P=0.035), with meta-analysis (19,574 PD cases and 468,488 controls) confirming increased risk (OR=1.65, P=3.69E-07). Carriers were shown to have significantly younger ages at onset compared to non-carriers (NeuroX: 56.4 vs. 61.4 years; Exome: 38.5 vs. 43.1 years). Stratifying by mutation type, we provide preliminary evidence for a more pathogenic risk profile for single PARK2 copy number variant (CNV) carriers compared to single nucleotide variant carriers. Studies that did not assess biallelic PARK2 mutations or consist of predominantly early-onset cases may be biasing these estimates, and removal of these resulted in a loss of association (OR=1.23, P=0.614; n=4). Importantly, when we looked for additional CNVs in 30% of PD cases with apparent monoallellic PARK2 mutations we found that 44% had biallelic mutations suggesting that previous estimates may be influenced by cryptic biallelic mutation status. While this study supports the association of single PARK2 mutations with PD, it highlights confounding effects therefore caution is needed when interpreting current risk estimates. Together, we demonstrate that comprehensive assessment of biallelic mutation status is essential when elucidating PD risk associated with monoallelic PARK2 mutations.

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