scholarly journals Randomized Trial to Reduce Air Particle Levels in Homes of Smokers and Children

2017 ◽  
Author(s):  
Vincent Berardi

Exposure to fine particulate matter in the home from sources such as smoking, cooking, and cleaning may put residents, especially children, at risk of detrimental health effects.Data from a randomized clinical trial were analyzed during 2016-2017 to determine whether real-time feedback in the home plus brief coaching of parents or guardians could reduce exposure to fine particles for children living with smokers.

2014 ◽  
Vol 2014 ◽  
pp. 1-14 ◽  
Author(s):  
Wen-cai Zhang ◽  
Yan-ge Wang ◽  
Zheng-feng Zhu ◽  
Fang-qin Wu ◽  
Yu-dong Peng ◽  
...  

Objective. To investigate the role of CD4+CD25+T cells (Tregs) in protecting fine particulate matter (PM-) induced inflammatory responses, and its potential mechanisms.Methods. Human umbilical vein endothelial cells (HUVECs) were treated with graded concentrations (2, 5, 10, 20, and 40 µg/cm2) of suspension of fine particles for 24h. For coculture experiment, HUVECs were incubated alone, with CD4+CD25−T cells (Teff), or with Tregs in the presence of anti-CD3 monoclonal antibodies for 48 hours, and then were stimulated with or without suspension of fine particles for 24 hours. The expression of adhesion molecules and inflammatory cytokines was examined.Results. Adhesion molecules, including vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1), and inflammatory cytokines, such as interleukin (IL-) 6 and IL-8, were increased in a concentration-dependent manner. Moreover, the adhesion of human acute monocytic leukemia cells (THP-1) to endothelial cells was increased and NF-κB activity was upregulated in HUVECs after treatment with fine particles. However, after Tregs treatment, fine particles-induced inflammatory responses and NF-κB activation were significantly alleviated. Transwell experiments showed that Treg-mediated suppression of HUVECs inflammatory responses impaired by fine particles required cell contact and soluble factors.Conclusions. Tregs could attenuate fine particles-induced inflammatory responses and NF-κB activation in HUVECs.


Author(s):  
Busisiwe Shezi ◽  
Angela Mathee ◽  
Nokulunga Cele ◽  
Sipho Ndabandaba ◽  
Renee A. Street

(1) Exposure of informal artisanal cookware makers to fine particles has not yet been characterized. The aim of this study was to characterize occupational exposure to fine particulate matter (PM4 and PM2.5) levels and fine particulate matter (PM2.5) elemental components; (2) Artisanal cookware makers were recruited from five cookware making sites. Exposure to fine particulate matter was measured for 17 male participants. SidePak personal aerosol monitors (AM520) were used to measure personal exposure to PM4, while a DustTrak monitor and an E-sampler were used to assess indoor and outdoor PM2.5 levels, respectively. A questionnaire was administered to capture information on demographic characteristics. The chemical characterization of indoor and outdoor PM2.5 filter mass was conducted using Wavelength Dispersive X-ray Fluorescence. Time series record of 15-min averages for indoor and outdoor PM2.5 levels were assessed; (3) The median (range) was 124 µg/m3 (23−100,000), 64 µg/m3 (1−6097) and 12 µg/m3 (4−1178), respectively, for personal PM4, indoor and outdoor PM2.5. The highest levels for many of the elemental components of PM2.5 were found in the outdoor PM2.5 filter mass and (4). The information generated during this study may assist in extending occupational health and safety strategies to artisanal cookware makers and developing targeted prevention initiatives.


Author(s):  
Hyungyu Park ◽  
Seonghyun Park ◽  
Janghoo Seo

Fine particulate matter entering the body through breathing cause serious damage to humans. In South Korea, filter-type air purifiers are used to eliminate indoor fine particulate matter, and there has been a broad range of studies on the spread of fine particulate matter and air purifiers. However, earlier studies have not evaluated an operating method of air purifiers considering the inflow of fine particulate matter into the body or reduction performance of the concentration of fine particulate matter. There is a limit to controlling the concentration of fine particulate matter of the overall space where an air purifier is fixed in one spot as the source of indoor fine particulate matter is varied. Accordingly, this study analyzed changes in the concentration of indoor fine particulate matter through an experiment according to the discharging method and location of a fixed air purifier considering the inflow route of fine particulate matter into the body and their harmfulness. The study evaluated the purifiers’ performance in reducing the concentration of fine particulate matter in the occupants’ breathing zone according to the operation method in which a movable air purifier responds to the movement of occupants. The results showed the concentration of fine particulate matter around the breathing zone of the occupants had decreased by about 51 μg/m3 compared to the surrounding concentration in terms of the operating method in which an air purifier tracks occupants in real-time, and a decrease of about 68 μg/m3 in terms of the operating method in which an air purifier controls the zone. On the other hand, a real-time occupant tracking method may face a threshold due to the moving path of an air purifier and changes in the number of occupants. A zone controlling method is deemed suitable as an operating method of a movable air purifier to reduce the concentration of fine particulate matter in the breathing zone of occupants.


1971 ◽  
Vol 11 (04) ◽  
pp. 367-373 ◽  
Author(s):  
Jerry B.F. Champlin

Abstract The movement of fine particles through porous, permeable materials is closely interwoven with the migration of soluble ions. Since either the particles orthe ions can represent an economic mineral accumulation as a consequence ofgeochemical concentration, it is of great importance to mineral explorationefforts to be able to establish the parameters that influence particulatemigration through aquifers. Not only are economically interesting depositsformed by such migration, but they also may be ruined, as in the case of manyoil fields where standard secondary recovery methods have caused plugging ofthe productive formations. Recent experimental work has shown close alliance between the relative movement of both trace ions and particles and the over-all concentration of common salts dissolved in ground water. Most importantly, the spacial stability of fineparticles such as the sesquioxides and the clays in formations is dependent onthe nature of the anionic portion of the dominant salt in solution. These results have great potential, applied in exploration or exploitation programs for minerals. Not only do they provide answers for particulate migration problems in the oil fields and ore concentration mechanisms in the uranium deposits, but also they explain the untoward migration of certain radioisotopes from waste storage ponds or cribs at the national reactor-fuel reprocessing plants. By careful development and engineering practice, fine particles tagged with almost any radioactive or activatable ions may become one of the most useful tools in tracing subsurface movement of fluids. Introduction Considerable concern has been expressed by several industries during the past several decades about the effects of fine-particulate matter suspended in water passing through permeable rock. An early concern of the petroleum industry included the problem of subsurface reservoir plugging by fine particles during secondary production operations. More recently, the atomic energy industry has been concerned with particulate migration because of the movement of radioactive ions. Even the interest in applications of nuclear explosions underground has included concern over the effects of the fine-particulate matter that makes up large portions of the rubble produced by the explosion.


2021 ◽  
pp. 118598
Author(s):  
Ashutosh K. Shukla ◽  
Vipul Lalchandani ◽  
Deepika Bhattu ◽  
Jay S. Dave ◽  
Pragati Rai ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document