scholarly journals Problem of the etiological diagnosis of a hemorrhagic stroke in cases of co-morbidity of ulcerative colitis, hepatitis C virus, arterial hypertension and blood coagulation disorder: Case report

2017 ◽  
Vol 3 (6) ◽  
pp. 264-266
Author(s):  
Patrice Ntenga ◽  
◽  
K Kabulo ◽  
O Cisse ◽  
S Mourabit ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Case Report ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Arterial Hypertension ◽  
Hemorrhagic Stroke ◽  
Coagulation Disorder ◽  
Etiological Diagnosis ◽  
Co Morbidity ◽  
Blood Coagulation Disorder

Treatment of chronic hepatitis C virus infection with crushed ledipasvir/sofosbuvir administered through a percutaneous endoscopic gastrostomy tube in a patient with HIV coinfection

2020 ◽  
Vol 78 (1) ◽  
pp. 36-40
Author(s):  
Vanessa Huffman ◽  
Diana C Andrade ◽  
Elizabeth Sherman ◽  
Jianli Niu ◽  
Paula A Eckardt
Keyword(s):  
Case Report ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Percutaneous Endoscopic Gastrostomy ◽  
Fixed Dose ◽  
Pharmacokinetic Data ◽  
Percutaneous Endoscopic Gastrostomy Tube ◽  
Endoscopic Gastrostomy ◽  
Hiv Coinfection ◽  
Peg Tube

Abstract Purpose Ledipasvir/sofosbuvir is an oral combination therapy containing fixed doses of direct-acting antiviral agents indicated for the treatment of hepatitis C virus (HCV) infection. Currently there are limited data on the clinical efficacy of crushed ledipasvir/sofosbuvir administered via feeding tube. Summary This case report discusses the successful treatment of chronic HCV genotype 1b infection with crushed ledipasvir/sofosbuvir administered through a percutaneous endoscopic gastrostomy (PEG) tube in a patient with human immunodeficiency virus (HIV) coinfection and high-grade sarcoma who had severe swallowing difficulties. The patient received crushed ledipasvir/sofosbuvir daily for a total of 12 weeks. At 12 weeks the patient had achieved a sustained virologic response. Conclusion Currently, ledipasvir/sofosbuvir is available only as a tablet, with limited pharmacokinetic data available to guide clinicians on use of the fixed-dose combination medication in crushed form. This case report highlights our experience treating a patient with HCV/HIV coinfection through administration of crushed ledipasvir/sofosbuvir via PEG tube, which we found to be a safe and effective therapeutic option.

Idenix v. Gilead: The enablement and written description limits of a genus claim

2021 ◽  
Vol 17 (2) ◽  
pp. 77-83
Author(s):  
Keith A Zullow ◽  
Cindy Chang ◽  
Sean Anderson
Keyword(s):  
Case Report ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Supreme Court ◽  
The Supreme Court ◽  
Federal Circuit ◽  
Written Description ◽  
Insufficient Number

In Idenix Pharms. LLC v. Gilead Sci. Inc., 941 F.3d 1149 (Fed. Cir. 2019), the Federal Circuit affirmed a judgment of invalidity of a patent claiming methods for treating Hepatitis C virus for, inter alia, lack of enablement. The Supreme Court denied Idenix’s petition for a writ of certiorari, meaning that the Federal Circuit decision stands, and genus claims covering thousands of compounds that were supported by an insufficient number of examples have failed the enablement test not once, but twice. See Wyeth & Cordis Corp. v. Abbott Labs., 720 F.3d 1380 (Fed. Cir. 2013). This case report presents the context surrounding the Federal Circuit’s Idenix decision and the Supreme Court’s decision not to hear the case.

scholarly journals Hepatitis C Virus Reactivation Following COVID-19 Vaccination – A Case Report

2021 ◽  
Vol Volume 14 ◽  
pp. 573-576
Author(s):  
Ruud Lensen ◽  
Mihai G Netea ◽  
Frits Rosendaal
Keyword(s):  
Case Report ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Reactivation

Interferon-α Therapy and Anti–Human Leukocyte Antigen Antibodies in Hepatitis C Virus–Positive Patient: Case Report

2007 ◽  
Vol 39 (6) ◽  
pp. 2040-2041 ◽  
Author(s):  
C. Cervelli ◽  
G. Fontecchio ◽  
M.A. Fioroni ◽  
R. Azzarone ◽  
C. Battistoni ◽  
...  
Keyword(s):  
Case Report ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Human Leukocyte Antigen ◽  
Human Leukocyte ◽  
Positive Patient ◽  
Interferon Α ◽  
Patient Case ◽  
Leukocyte Antigen

scholarly journals The effect of antiviral therapy on hepatitis C virus-related thrombocytopenia: a case report

2014 ◽  
Vol 7 (1) ◽  
pp. 59 ◽  
Author(s):  
Rita Lebano ◽  
Valerio Rosato ◽  
Mario Masarone ◽  
Marco Romano ◽  
Marcello Persico
Keyword(s):  
Case Report ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Antiviral Therapy

Hepatitis C Virus and Professional Risk in Anesthesia and Intensive Care: A Case Report

1998 ◽  
Vol 19 (11) ◽  
pp. 823-823
Author(s):  
Leila Bakir ◽  
Moncef Ben Ayed ◽  
Olfa Chourou ◽  
Mohamed-Salah Ben Ammar ◽  
Najia Ben Salah
Keyword(s):  
Intensive Care ◽  
Case Report ◽  
Hepatitis C Virus ◽  
Hepatitis C
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