Pulmonary hamartoma, a rare benign tumour of the lung - Case series

Introduction - Pulmonary hamartoma, with incidence of 0.25-0.32%, accounts for 6% of solitary pulmonary nodules. The role of radiology is limited as only 10-30% of cases show characteristic ‘popcorn’ calcification and Computed Tomography can detect approximately 50% of hamartomas. Hence cytological and/or histopathological examination is required to make a definitive diagnosis and exclude malignancy. Objective – As pulmonary hamartoma is a rare entity detected serendipitously on radiography and requires cytological and histopathological examination for confirmation of diagnosis, we present nine cases of solitary pulmonary nodules which were diagnosed as pulmonary hamartoma. Methods - We retrospectively screened departmental records and slides and found nine cases of pulmonary hamartoma in our tertiary care institute. Three cases were diagnosed on CT guided Fine Needle Aspiration Cytology and four cases were diagnosed on histopathological examination of surgical specimens, over a period of 16 years (1997-2012). Two cases were incidentally discovered to have pulmonary hamartoma at autopsy. Observations – The age of the patients ranged from 17-63 years (mean-46.3), with male to female ratio being 3.5:1. The size of the hamartoma varied from 0.4 – 1.3 cm, with mean diameter of 1 cm. Cytology showed mixture of bronchial epithelial cells, adipocytes and stromal fragments in fibromyxoid and chondroid background. Histopathology demonstrated lobules of cartilage and adipose tissue with intervening clefts lined by respiratory epithelium and mesenchymal stroma. Conclusion – Every solitary pulmonary nodule is not malignant. It is important to correctly diagnose pulmonary hamartoma, a rare, yet benign neoplasm presenting as a solitary lung nodule and distinguish it from malignancy.Asian Journal of Medical Science, Volume-5(3) 2014: 112-115 http://dx.doi.org/10.3126/ajms.v5i3.9243

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Histopathological Study of Lesions of the Nasal Cavity, Paranasal Sinuses and Nasopharynx in a Tertiary Care Centre, Visakhapatnam over a Period of 2 Years

Journal of Evidence Based Medicine and Healthcare ◽

10.18410/jebmh/2021/557 ◽

2021 ◽

Vol 8 (33) ◽

pp. 3054-3059

Author(s):

Rajendra Prasad Jagannadham ◽

Lakshmi Latchupatula ◽

Sravani Ponnada ◽

Neelima Lalam ◽

Raghunadhababu Gudipudi ◽

...

Keyword(s):

Nasal Cavity ◽

Paranasal Sinuses ◽

Histopathological Examination ◽

Tertiary Care ◽

Histopathological Study ◽

Histopathological Diagnosis ◽

Malignant Tumours ◽

Tertiary Care Centre ◽

Female Ratio ◽

Male Predominance

BACKGROUND A variety of non - neoplastic and neoplastic conditions involve the nasal cavity, paranasal sinuses and nasopharynx and these are very common lesions encountered in clinical practice. Histopathological examination of these lesions is the gold standard for diagnosis because management and prognosis vary among different lesions. The aim of the present study was to evaluate the histopathological study of the lesions of the nasal cavity, paranasal sinuses and nasopharynx in relation to their incidence, age, gender and site wise distribution and to compare the results with the available data. METHODS A study of 88 cases was conducted for a period of 2 years from August 2017 to July 2019. After fixation, Processing and Haematoxylin and Eosin staining and special stains histopathological diagnosis was made. RESULTS Among 88 total cases, 58 were males and 30 were females. A male predominance was observed with a male to female ratio of 1.93 : 1. They were more common in third, fourth and fifth decade of life. Malignant nasal lesions were seen after fourth decade of life. Nasal lesions were more common in nasal cavity (67.05 %), followed by paranasal sinuses (18.18 %) and nasopharynx (14.75). Out of 88 total cases, 39 (44.32 %) were non - neoplastic, 30 (34.09 %) were benign and 19 (21.59 %) were malignant nasal lesions. CONCLUSIONS Sinonasal lesions and nasopharyngeal lesions can have various differential diagnoses. A complete clinical, radiological and histopathological correlation helps to categorize these sinonasal lesions into various non - neoplastic and neoplastic types. But histopathological examination remains the mainstay of definitive diagnosis. KEYWORDS Nasal Cavity, Paranasal Sinuses, Nasopharynx, Benign Tumours, Malignant Tumours, Histopathological Examination

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Radial EBUS versus CT-guided needle biopsy for evaluation of solitary pulmonary nodules

Oncotarget ◽

10.18632/oncotarget.23952 ◽

2018 ◽

Vol 9 (19) ◽

pp. 15122-15131 ◽

Cited By ~ 6

Author(s):

Wei Wang ◽

Like Yu ◽

Yuchao Wang ◽

Qian Zhang ◽

Chuanzhen Chi ◽

...

Keyword(s):

Needle Biopsy ◽

Pulmonary Nodules ◽

Solitary Pulmonary Nodules ◽

Ct Guided

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Transesophageal endoscopic ultrasound fine needle aspiration of vertebral body osteolytic tumors – a novel diagnostic approach. Case series.

Medical Ultrasonography ◽

10.11152/mu-2618 ◽

2020 ◽

Author(s):

Romeo Ioan Chira ◽

Alina Florea ◽

Vlad Ichim ◽

Liliana Rogojan ◽

Alexandra Chira ◽

...

Keyword(s):

Vertebral Body ◽

Endoscopic Ultrasound ◽

Fine Needle Aspiration ◽

Histopathological Examination ◽

Traditional Approach ◽

Case Series ◽

Lumbar Vertebrae ◽

Needle Aspiration ◽

Ct Guided ◽

Fine Needle

Aims: Vertebral lesions, either primary or more frequently metastasis, are difficult targets for percutaneous guided biopsies and surgical biopsies and are associated with greater risks of complications. We investigated the feasibility of endoscopic ultrasound (EUS) fine needle aspiration (FNA) biopsy in the assessment of vertebral osteolytic tumors as an alternative to CT guided biopsy which is the technique currently used.Material and methods: Four patients with osteolytic tumors of the vertebral bodies identified by imaging methods (CT or MRI) – 3 patients, and one with a tumor detected primarily during EUS procedure were included in order to evaluate the feasibility of the procedure. The lesions were located either at the dorsal or lumbar vertebrae. In all cases we performed EUS FNA of the osteolytic vertebral body lesions with 22G needles using the transesophageal or transgastric approach.Results: In all cases EUS FNA provided enough tissue for an accurate histopathological report, with no procedural complication. We diagnosed lung adenocarcinoma, hepatocarcinoma and a pancreatic adenocarcinoma vertebral metastasis and one case of lymphoma.Conclusions: EUS FNA is a valuable technique which should be considered in selected cases, when a “traditional approach” is not applicable or associated with a higher risk. Treatment guidelines are based on the histology of the tumor, histopathological examination being nowadays mandatory. Therefore, we propose for selected cases a feasible technique, with significantly lower procedural risks, as an alternative for open surgical biopsies or computed tomography guided biopsies

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Role of CT guided lung biopsy in solitary pulmonary nodules with a moderate to high risk of malignancy

Lung Cancer ◽

10.1016/s0169-5002(18)30076-x ◽

2018 ◽

Vol 115 ◽

pp. S20

Author(s):

B. Hawramy ◽

L. Cheyne ◽

J. Martin ◽

M. Kon

Keyword(s):

High Risk ◽

Lung Biopsy ◽

Pulmonary Nodules ◽

Solitary Pulmonary Nodules ◽

Ct Guided ◽

Risk Of Malignancy

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A retrospective clinico-pathological study of hysterectomy cases in a tertiary care hospital in India – a review of 950 cases.

Bangladesh Journal of Medical Science ◽

10.3329/bjms.v17i1.35287 ◽

2018 ◽

Vol 17 (1) ◽

pp. 88-92

Author(s):

Pal Subrata ◽

Chakrabarti Srabani ◽

Sinha Anuradha ◽

Phukan Jyoti Prakash ◽

Bose Kingshuk ◽

...

Keyword(s):

Clinical Diagnosis ◽

Histopathological Examination ◽

Tertiary Care ◽

Medical Science ◽

Abdominal Hysterectomy ◽

Uterine Bleeding ◽

Histopathological Diagnosis ◽

Care Hospital ◽

Dysfunctional Uterine Bleeding ◽

Common Indication

Introduction: Hysterectomy is the most commonly performed gynaecological surgery in India as well as in abroad. It is frequently done in myometrial and endometrial pathologies and rarely for other causes. Hysterectomy is definitive management for diseases like fibroid, adenomyosis, dysfunctional bleeding, prolapsed uterus and malignant lesions of uterus and adenexa. We aimed our study to observe incidence of different pathologies of uterus and other reproductive organs in hysterectomy specimens and retrospective correlation between clinical diagnosis and histopathological finding of hysterectomy cases.Materials and Methods: Retrospective data were collected from our routine histopathological laboratory. Detailed history, clinical examination and operative findings and provisional diagnosis of all 950 hysterectomy cases were recorded during study period of 2 years. Histopathological diagnosis was correlated with clinical and preoperative diagnosis.Observations: Abdominal hysterectomy (734 cases, 77.26%) was the most common route of approach during surgery. Common pre-operative diagnoses were fibroid uterus (32%), dysfunctional uterine bleeding (28.95%), uterine prolapsed (22.74%). Other causes included uterine polyps (1.6%), complications of pregnancy (2.74%), ovarian tumours (8.42%), cervical carcinomas (2.97%) etc. Common pathologies on histology were leiomyoma (32%), adenomyosis (20.32%), atrophic endometrium (17.26%) and endometrial pathology (8.95%).Discussion: Our study has been correlated with other studies of India and other south Asian countries. Most common indication of hysterectomy in our study is dysfunctional uterine bleeding (32%) but Gupta et al and Jha R et al found utero-vaginal prolapse as most common indication. Leiomyoma was the most common histology diagnosed in the present series. Clinical diagnosis was possible in 67.57% cases in our study similar to Khan et al (70.51%).Conclusions: Histopathological examination of hysterectomy specimens helps to detect the exact causes and underlined pathology.Bangladesh Journal of Medical Science Vol.17(1) 2018 p.88-92

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CT-Guided Fine-Needle Aspiration Cytology of Solitary Pulmonary Nodules*

CHEST Journal ◽

10.1378/chest.112.2.423 ◽

1997 ◽

Vol 112 (2) ◽

pp. 423-425 ◽

Cited By ~ 94

Author(s):

Luigi Santambrogio ◽

Mario Nosotti ◽

Nadia Bellaviti ◽

Gianni Pavoni ◽

Ferdinando Radice ◽

...

Keyword(s):

Fine Needle Aspiration ◽

Fine Needle Aspiration Cytology ◽

Pulmonary Nodules ◽

Needle Aspiration ◽

Solitary Pulmonary Nodules ◽

Aspiration Cytology ◽

Ct Guided ◽

Fine Needle ◽

Needle Aspiration Cytology

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Clinico-pathological and radiological correlation of sino-nasal masses in a tertiary care center

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20202790 ◽

2020 ◽

Vol 6 (7) ◽

pp. 1342

Author(s):

Dimple Sahni ◽

Gagandeep Kaur ◽

Peeyush Verma ◽

Rajwant Kaur ◽

Harpal Singh

Keyword(s):

Histopathological Examination ◽

Care Center ◽

Tertiary Care ◽

Inflammatory Lesion ◽

P Value ◽

Radiological Investigation ◽

Female Ratio ◽

Histopathological Correlation ◽

Neoplastic Lesion ◽

Neoplastic Lesions

Background: The nasal masses are most commonly encountered condition in outpatient department of otorhinolaryngology. The purpose of this study was to show the clinical, radiological and histopathological correlation of sino nasal masses.Methods: This study was conducted on 100 cases with sino nasal masses over a period of 2 years. A provisional diagnosis was made after clinical and radiological investigation which was confirmed with histopathological examination and the findings were correlated. Results: The number of non-neoplastic lesions were more than neoplastic lesions (75% vs 25%). Incidence was highest in the age group of 31-40 year (21%) with male to female ratio of 1.5:1. In our study among non-neoplastic lesion, inflammatory lesion had highest frequency (75%). We found clinical and histopathological correlation in 94.6% cases (p value 0.04). 93.33% cases correlated radiologically and histopathologically (p value 0.04). Conclusions: We concluded that for proper evaluation of sino nasal masses, clinical, radiological, histopathological evaluation should be carried out conjointly. Histopathologic evaluation remains the gold standard.

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Primary pulmonary lymphoma presenting as nodules and masses: a case report and literature review

Monaldi Archives for Chest Disease ◽

10.4081/monaldi.2021.1259 ◽

2021 ◽

Vol 91 (1) ◽

Author(s):

Xiaofang Gao ◽

Peng Yan

Keyword(s):

Histopathological Examination ◽

Pulmonary Nodules ◽

Transthoracic Needle Biopsy ◽

Ct Guided ◽

Primary Pulmonary Lymphoma ◽

Contrast Enhanced ◽

Pulmonary Lymphoma ◽

Old Men ◽

Percutaneous Transthoracic Needle Biopsy ◽

Multiple Nodules

Primary pulmonary lymphoma (PPL) is a rare neoplasm. We report a case of 45-year-old men who was admitted to hospital for multiple nodules and masses in both lungs. The contrast enhanced chest CT scans revealed multiple nodules and masses of varying sizes in right upper and middle lobes and both lower lobes. CT-guided percutaneous transthoracic needle biopsy was performed. The diagnosis of PPL was confirmed by histopathological examination and Immunohistochemical staining. PPL should be included in the differential diagnoses in symptomless patients with multiple pulmonary nodules and masses.

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Myasthenia Gravis in Patients with Histopathologically Diagnosed Thymoma at Sanglah General Hospital: A Case Series

Indonesian Journal of Cancer ◽

10.33371/ijoc.v15i2.772 ◽

2021 ◽

Vol 15 (2) ◽

pp. 91

Author(s):

Desak Putu Gayatri Saraswati Seputra ◽

I Gusti Ayu Sri Mahendra Dewi

Keyword(s):

Myasthenia Gravis ◽

General Hospital ◽

Muscle Weakness ◽

Histopathological Examination ◽

Early Recognition ◽

Regional Lymph Node ◽

Case Series ◽

Epithelial Tissue ◽

Muscle Involvement ◽

Female Ratio

Introduction: Thymoma is a neoplasm of the thymus gland which arises from the epithelial tissue. Thymoma is frequently related to various paraneoplastic syndromes, most commonly myasthenia gravis. Up to 50% of patients with thymoma are reported to develop myasthenia gravis, whereas 10–15% of patients with myasthenia gravis are found to have thymoma. Case Presentation: This case series reported 3 patients with myasthenia gravis which co-occurred with thymoma at Sanglah General Hospital from 2018 to 2019. The patients’ ages range from 33 to 61 years (mean age 46 ± 11 years) with a 2:1 male-to-female ratio. The diagnosis of myasthenia gravis was made by the presentation of typical myasthenia gravis appearances, the fluctuating intensity of ocular and bulbar muscle weakness (all three cases), and limbs and axial muscle weakness (one case); no respiratory muscle involvement was found. Physical and supporting examinations including electroneuromyography results were coherent with myasthenia gravis. The diagnosis of thymoma was made by highly suggestive appearance in Thorax Multi Sliced Computed Tomography (MSCT) scan examination and histopathologic findings. MSCT scan examination showed a well-circumscribed ovoid solid mass in the mediastinum (left anterosuperior, superior, and anterior to middle right mediastinum) sized from 1.8x1.5x2.9 cm to 8.1x9.9x9.7 cm, enhanced with contrast injection with areas of calcification and central necrotic (1 case) and no dissemination to regional lymph node and neighboring organs. All cases received acetylcholinesterase inhibitors and underwent extended thymectomy. Histopathological examination showed accordance with thymoma features of subtype A, AB, and B1.Conclusions: Clinicians should be aware of the thymoma and myasthenia gravis co-existence possibility to ensure early recognition and appropriate management.

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