scholarly journals Relation of Age and Serum Prostatic-Specific Antigen level with Histopathological diagnosis in Transurethral Resection of Prostate specimen, an Experience from Eastern Tertiary Hospital

2019 ◽  
Vol 17 (2) ◽  
pp. 62-65
Author(s):  
Ram Sagar Shah ◽  
Dipesh Raj Pandey
Keyword(s):  
Transurethral Resection ◽  
Specific Antigen ◽  
Tertiary Hospital ◽  
Interquartile Range ◽  
Transurethral Resection Of Prostate ◽  
Histopathological Diagnosis ◽  
Prostatic Specific Antigen ◽  
Carcinoma Prostate ◽  
Common Diagnosis ◽  
Prostate Diseases

Background: Prostatic Specific Antigen (PSA) is a protease secreted by epithelial cells of prostate. Serum PSA level is increased when the normal structure of gland is destroyed by benign or malignant tumor or inflammation. Though there is established relation between PSA plasma level and age among the two most common prostate diseases (Benign prostatic hyperplasia and Carcinoma Prostate) in the literature, relation has not been explored in our part of the world, therefore, this study was done to see the relation between age and PSA amount with Prostate diseases. Material and Methods: This was a Cross-sectional study conducted in a tertiary hospital, Nobel Medical College Teaching Hospital from January 2017 to December 2018. Ethical clearance was obtained from Institutional Review Committee (IRC). All the cases of prostate diseases presenting to urology department undergoing transurethral resection of the prostate (TURP) were included. Histopathology report of TURP specimen were collected from department of pathology and the relationship between diagnosis, PSA level and age were established. Results: BPH was the most common diagnosis (72.41%). Age of BPH patients ranged from 48-78 years and mean age with SD was 60.56±7.32. Median age with interquartile range was 61.00. Similarly, in the BPH group, PSA value ranged between 0.80-15.40 ng/ml with mean PSA value along with SD being 5.64±4.16 ng/ml. Similarly, Median PSA value with interquartile range was 4.20ng/ml. Carcinoma Prostate (27.59%) was the second most common diagnosis. Histological type of all cases diagnosed as cancer was adenocarcinoma. Their age ranged between 54-83. Their mean age with SD was 67.67±7.68. Similarly, Median age with interquartile range was 68.00. PSA value in this group ranged between 8.50-147.30 ng/ml. Again, the mean PSA value with SD is 55.72±33.40 ng/ml. Similarly, Median PSA value with interquartile range is 54.30 ng/ml. Conclusion: PSA level in the blood of men over 40years is highly correlated with a Age, irrespective of diagnosis. In above 40 age group, with advancing age, Carcinoma Prostate becomes more and more common diagnosis than BPH. Similarly, average PSA level is higher in Carcinoma Prostate than BPH.

scholarly journals Endogenous testosterone to prostate-specific antigen relationship in men without prostatic diseases: a 10-year retrospective study

2018 ◽  
Vol 5 (4) ◽  
pp. 1186
Author(s):  
Promise N. Wichendu ◽  
Ehimen P. Odum ◽  
Collins Amadi ◽  
Benjamin M. Aleme
Keyword(s):  
Retrospective Study ◽  
Specific Antigen ◽  
Serum Testosterone ◽  
Tertiary Hospital ◽  
Total Testosterone ◽  
Hospital Data ◽  
Testosterone Levels ◽  
Prostatic Diseases ◽  
Total Psa ◽  
Prostate Diseases

Background: The relationship between endogenous testosterone and PSA in men without prostatic diseases is controversial. Hence, this study was designed to investigate this relationship among healthy Nigerian men.Methods: A retrospective study of serum total testosterone (TT) and total PSA records of 1066 prostate disease-free men was undertaken in a Nigerian tertiary Hospital. Data on age, serum testosterone, and PSA from 1st January 2007 to December 2016 was abstracted and analysed.Results: The mean age, serum PSA, and serum total testosterone levels among study cohorts are 58.40±12.24 years, 3.0±2.24 µg/l, and 15.5±0.53 nmol/l respectively. There was an inverse relationship between serum PSA and testosterone levels with age. Subjects with high-risk PSA level (PSA>4.0 µg/l) had statistically significant higher PSA (p<0.001) and TT (p<0.001) values compared to the low-risk PSA level group. Subjects in the eugonadism group had higher PSA levels than those in the hypogonadism group (eugonadism 3.90µg/l±2.22 versus hypogonadism 2.18µg/l±2.30; p=0.012). Age correlated positively with PSA (p<0.001), but negatively with TT (p<0.001) while PSA correlated positively with TT (p<0.001).Conclusions: The findings of this study suggest an association between endogenous TT and PSA among healthy men without prostatic diseases and augment the evidence that serum TT maybe linked to prostate diseases. Clinical decisions regarding PSA should factor the levels of endogenous TT to enhance clinical judgments.

scholarly journals Study on Correlation between Serum Prostate Specific Antigen and Various Prostatic Pathology

2018 ◽  
Vol 1 (2) ◽  
pp. 70-73
Author(s):  
Nirajan Mainali ◽  
Niraj Nepal ◽  
Prabesh Kumar Chaudhary ◽  
Jit Shrestha
Keyword(s):  
Histopathological Examination ◽  
Specific Antigen ◽  
Outlet Obstruction ◽  
Blood Stream ◽  
Study Patient ◽  
Antigen Level ◽  
Prostatic Specific Antigen ◽  
Medical College ◽  
Common Diagnosis ◽  
Organ Specific

Introduction: Prostatic enlargement that may due to any cause may give rise to bladder outlet obstruction. Prostatic specific antigen is the enzyme that is responsible for liquefaction of semen within a few minutes after it has clotted. Prostatic specific antigen is a widely used tumor marker for prostatic cancer. Prostatic specific antigen levels in the blood go up if the barrier between the lining epithelium and the blood stream is damaged. This study was done to determine the correlation between serum Prostatic specific antigen level and histological diagnosis in prostatic biopsy.Material and Methods: This is a one year prospective study carried out in the Department of Pathology, Nobel Medical College from August 16, 2016 to August 15 2017. A total of 175 cases were included in the study. Patient Prostatic specific antigen level were noted and biopsy specimen was collected after operation. Histopathological examination was done and correlation between HPE diagnosis and serum Prostatic specific antigen level was done.Results: Benign Prostatic Hyperplasia was the most common diagnosis that was encountered. Majority of the cases had a serum Prostatic specific antigen level less than 10 ng/ml. Serum Prostatic specific antigen level of more than 30 ng/ml was seen only in prostatic carcinoma.Conclusions: Serum Prostatic specific antigen is organ specific but not a disease for prostate. It can be used to monitor the carcinoma of the prostate rather than the diagnosis of the carcinoma.

scholarly journals An Updated Meta-Analysis of the Efficacy and Safety of Prostatic Artery Embolization vs. Transurethral Resection of the Prostate in the Treatment of Benign Prostatic Hyperplasia

2021 ◽  
Vol 8 ◽  
Author(s):  
Zhunan Xu ◽  
Zhongbao Zhou ◽  
Yingmei Mu ◽  
Tong Cai ◽  
Zhenli Gao ◽  
...  
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Transurethral Resection ◽  
Meta Analysis ◽  
Specific Antigen ◽  
Prostatic Hyperplasia ◽  
Transurethral Resection Of Prostate ◽  
Efficacy And Safety ◽  
Artery Embolization ◽  
Prostatic Artery Embolization ◽  
Prostatic Artery

Background: Prostatic artery embolization (PAE) in the treatment of benign prostatic hyperplasia (BPH) has been introduced into clinical practice, but conclusive evidence of efficacy and safety has been lacking.Objective: To compare the efficacy and safety of prostatic artery embolization (PAE) vs. transurethral resection of prostate (TURP), we performed a meta-analysis of clinical trials.Methods: We searched randomized controlled trials (RCTs) from Pubmed, Embase, Wanfang, and CNKI from January 2000 to December 2020 and used RevMan 5.0 to analyze the data after five RCTs were included.Results: The reducing of prostate volume (PV) [Median mean (MD) 14.87; 95% confidence interval (CI) 7.52–22.22; P &lt; 0.0001] and the increasing of maximum flow rate in free uroflowmetry (Qmax) (MD 3.73; 95% CI 0.19–7.27; P = 0.004) were more obvious in TURP than in PAE; however, the rate of lower sexual dysfunction [odds ratio (OR) 0.12; 95% CI 0.05–0.30; P &lt; 0.00001] was lower in PAE compared with TURP. Meanwhile, no conspicuous difference in International Prostate Symptoms Score (IPSS) score (MD 1.42; 95% CI −0.92 to 3.75; P = 0.23), quality of life (Qol) score (MD 0.21; 95% CI −0.31 to 0.73; P = 0.43), post void residual (PVR) (MD 21.16; 95% CI −5.58 to 47.89; P = 0.12), prostate-specific antigen (PSA) (MD 0.56; 95% CI −0.15 to 1.27; P = 0.12), and complications (OR 0.90; 95% CI 0.20–4.05; P = 0.89) between PAE and TURP group was shown.Conclusion: PAE may replace TURP as an alternative treatment for Benign prostatic hyperplasia (BPH) patients who do not want to have surgery or with operational contraindications.

scholarly journals A STUDY ON CORRELATION OF SERUM PROSTATE SPECIFIC ANTIGEN WITH CLINICAL AND PATHOLOGICAL VARIABLES IN PATIENTS OF PROSTATOMEGALY

2021 ◽  
Vol 5 (10) ◽  
Author(s):  
Sanjay Patidar ◽  
Kritika Kamal ◽  
Jaydip Sinh Kathota ◽  
Sudhanshu Tiwari ◽  
Prashant Nakrani
Keyword(s):  
Prostate Cancer ◽  
Prostate Specific Antigen ◽  
Cancer Detection ◽  
Specific Antigen ◽  
Digital Rectal Examination ◽  
Age Group ◽  
Rectal Examination ◽  
Carcinoma Prostate ◽  
Total Psa ◽  
Prostate Diseases

Background: In clinical practice, biopsies are generally performed only when the results ofprostate specific antigen (PSA) test or digital rectal examination (DRE) are abnormal. This leads to misdiagnosis of most small prostatic cancers present in many older men. Patients with lower urinary tract infection (LUTS) who have serum PSA levels higher than 4ng/ml are primarily advised to undergo prostate biopsy to rule out cancer. However, PSA is organ specific not disease specific, so the presence of other prostate diseases such as benign prostatic hyperplasia (BPH) and prostatitis may influence its effectiveness for cancer detection. Hence, the PSA based prostate cancer detection is fraught with high false positive rate. Aim:To evaluate the utility of PSA assay as a method of investigation in diagnosis of prostatic lesion. Objectives: The use of Serum PSA levels for the early detection of prostate cancer and evaluate its role with other modalities for diagnosis of prostate cancer and to diagnose different diseases of prostate, i.e. prostatitis, BPH in prostatomegaly, and its correlation with Serum PSA levels. Materials and Methods: This prospective descriptive study was conducted in Index Medical College, Hospital & Research Centre, Indore, M.P,India in the period of August 2019 to July 2021. The patients were selected from the outdoor Department of General Surgery. Results: A total of 80 male patients presenting with LUTS were included. Their mean age was 68.66 years. The majority i.e. 41 of the study group were in the age group of 61-70 years. 42 of patients had Serum PSA < 4ng/ml. Biopsy proven adenocarcinoma cases 34% of the cases are in the age group of 61-70 years. Out of the biopsy proven adenocarcinoma cases, DRE was suspicious of malignancy in 89%. Conclusion: Serum PSA levels have a significant correlation with the age group, with the increase in age there is rise in Serum PSA levels. Transabdominal ultrasound, DRE and Serum PSA has high sensitivity in diagnosis of prostatomegaly but it was found that none of the screening tool has got much efficacy in differentiating carcinoma prostate from benign hypertrophy, but the combination of DRE and Serum total PSA or DRE, Serum total PSA and ultrasound abdomen showed higher efficacy in diagnosis of carcinoma prostate. Increase in Serum PSA is directly related to carcinoma, but there is no absolute cut-off for Serum PSAfor diagnosis of carcinoma. Key-Words: Prostate specific antigen, Prostatomegaly, Benign Prostatic Hypertrophy, Digital Rectal Examination, International Prostate Severity Score, Carcinoma Prostate.

Serum Prostate Specific Antigen Levels after Transurethral Resection of Prostate

1996 ◽  
pp. 1035-1039 ◽  
Author(s):  
Leonard S. Marks ◽  
Frederick J. Dorey ◽  
Thomas Rhodes ◽  
Erlinda D. Shery ◽  
Harry Rittenhouse ◽  
...  
Keyword(s):  
Prostate Specific Antigen ◽  
Transurethral Resection ◽  
Specific Antigen ◽  
Transurethral Resection Of Prostate ◽  
Serum Prostate Specific Antigen

scholarly journals Efficacy of bipolar transurethral resection of the prostate using TURIS: our short term experience

2019 ◽  
Vol 6 (5) ◽  
pp. 1556
Author(s):  
Praveen Singh ◽  
Mohd Mubashir A. Khan
Keyword(s):  
Urethral Stricture ◽  
Transurethral Resection ◽  
Specific Antigen ◽  
Resected Specimen ◽  
Transurethral Resection Of Prostate ◽  
Urinary Flow ◽  
Short Term ◽  
Stricture Rate ◽  
The Mean

Background: Objective of the study was to report our short term experience regarding efficacy of bipolar transurethral resection of prostate using TURIS (transurethral resection in saline) system.Methods: Between May 2016 to April 2017 49 consecutive patients underwent bipolar transurethral resection of prostate (B-TURP) at our institute. All patients were evaluated preoperatively by physical examination, ultrasonography and laboratory studies, including measurement of hemoglobin, serum sodium, and prostate specific antigen levels. Patients were assessed postoperatively at three, six and 18 months.Results: The mean age of the patients was 64.83±7.47 years and mean preoperative prostate volume was 64.73±13.59 ml. The mean preoperative hemoglobin was 13.32±0.9 g/l and mean postoperative hemoglobin was 12.09±1.11 g/l. The mean resection time was 57.02±14.37 minutes and mean resected specimen weight was 41.69±12.15 gm. The mean preoperative maximum urinary flow rate (Qmax) was 8.6±1.17 ml/s and mean Qmax at three, six and 18 months follow up was 18.85±2.15, 19.43±1.49 and 18.98±1.6 ml/s respectively. The mean preoperative international prostate symptom score (IPSS) was 26.32±2.69 and mean IPSS at three, six and 18 months follow up was 6.68±1.36, 6.47±0.79 and 6.30±0.9 respectively. Only one patient developed urethral stricture during follow up.Conclusions: The B-TURP is efficacious and results in significant improvement in IPSS and Qmax. The urethral stricture rate after B-TURP is not different from monopolar TURP.

scholarly journals EKSPRESI Hsa-miR-22-3p PADA URIN PASIEN BENIGN PROSTATE HYPERPLASIA (BPH) SEBAGAI BIOMARKER NON INVASIF

2021 ◽  
Vol 20 (1) ◽  
pp. 93-102
Author(s):  
Angga Dwi Prasetyo
Keyword(s):  
Benign Prostate Hyperplasia ◽  
Specific Antigen ◽  
Digital Rectal Examination ◽  
Urine Samples ◽  
Transurethral Resection Of Prostate ◽  
Cross Sectional ◽  
Prostate Hyperplasia ◽  
Non Invasive ◽  
Prostate Diseases ◽  
Benign Prostate

Benign Prostate Hyperplasia (BPH) is one of prostate diseases with highest prevalence rates men in the world. Benign Prostate Hyperplasia are caused by many factors, such as disorders of androgen receptors, mutations genes, age, epigenetics and environment. Detection BPH in the form of Prostate Specific Antigen (PSA), Transurethral Resection Of Prostate (TURP) and Digital Rectal Examination (DRE) which is invasive in the patient. MicroRNAs in urine eksosomes can be used to detect BPH with non-invasive to patients. This study aims to determine the potential expression of Hsa-miR-22-3p in eksosomal urine samples of BPH as a non-invasive biomarker. This was an observational cross sectional analytic study. Urine samples were obtained from dr. Sardjito Yogyakarta and dr. Soeradji Tirtonegoro hospital. Furthermore, eksosomes isolation, RNA isolation, cDNA synthesis and quantification with qRT-PCR. Based on the results, it is known that Hsa-miR-22-3p decreased expression as much as 29.54 times in BPH, there were significant differences between samples of BPH and normal samples (P = 0.001). Thus Hsa-miR-22-3p has potential as a biomarker in Benign Prostate Hyperplasia. 

scholarly journals Change in Free To Total Prostate Specific Antigen Ratio Following Transurethral Resection of Prostate in Patient With Benign Prostatic Hyperplasia

2020 ◽  
Vol 18 (2) ◽  
pp. 83-87
Author(s):  
SM Yunus Ali ◽  
Md Saiful Islam ◽  
Mohammad Al Amin ◽  
Md Golam Mowla Choudhury ◽  
Isteaq Ahmed Shamim
Keyword(s):  
Prostate Specific Antigen ◽  
Transurethral Resection ◽  
Histopathological Examination ◽  
Urinary Tract Obstruction ◽  
Specific Antigen ◽  
Total Serum ◽  
Transurethral Resection Of Prostate ◽  
Free Psa ◽  
Lower Urinary Tract Obstruction ◽  
Total Psa

Objective- To determine the changes in free to total serum prostate specific antigen (PSA) ratio level after transurethral resection of prostate (TURP) in BPH patients at different interval of time. Materials & Methods- A total of 93 patients undergoing TURP for benign enlargement of prostate were included in the study. Serum total PSA and free PSA were assessed before operation and on the Ist and 7th postoperative day and at month 3 to determine the changes in total PSA, free PSA and free to total PSA ratio following TURP. Result- The preoperative mean total PSA, free PSA and free to total PSA ratio were 3.5 :L 1.7 ng/ml, 0.781 0.21 ng/ml and 0.28 + 0.07. In terms of IPSS, 75(80.7%) patients had severe lower urinary tract obstruction and 18(19.3%) moderate obstruction. Histopathological examination of the resected prostatic tissue revealed that all the 93 patients had benign prostatic lesion. Conclusion-The free and total PSA in first few days increases and thereafter it decreases in 3 months period following transurethral resection of prostate in men with BPH. As both these parameters decrease proportionately, the free to total PSA ratio remains consistent. If free to total PSA ratio decreases it raises suspicision about the early changes in malignancy. Bangladesh Journal of Urology, Vol. 18, No. 2, July 2015 p.83-87

Sign in / Sign up

Export Citation Format

Share Document