scholarly journals Histological assessment of the effect of neoadjuvant chemotherapy on conventional high grade osteosarcoma of the long bones

1970 ◽  
Vol 1 (1) ◽  
pp. 60-62
Author(s):  
JB Thapa
Keyword(s):  
Neoadjuvant Chemotherapy ◽  
Tumour Response ◽  
Poor Responders ◽  
High Grade ◽  
Medical Oncologist ◽  
Long Term Follow Up ◽  
High Grade Osteosarcoma ◽  
Histological Mapping

A multidisciplinary team of an orthopaedic surgeon, medical oncologist, radiologist and pathologist was involved in the management of osteosarcoma cases. Four cases of osteosarcoma were examined for the effects of neoadjuvant chemotherapy. Total histological mapping was done to study the postchemotherapy biopsies. Two cases were good responders (more than 90% response), and two cases were poor responders (less than 90% response). Good responders had limb sparing surgery performed on them. Long term follow up results are awaited. Keywords: Neoadjuvant chemotherapy; Osteosarcoma; Total histological mapping; Tumour response DOI: 10.3126/jpn.v1i1.4455 Journal of Pathology of Nepal (2011) Vol.1, 60-62

Long-Term Outcome for Patients With Nonmetastatic Osteosarcoma of the Extremity Treated at the Istituto Ortopedico Rizzoli According to the Istituto Ortopedico Rizzoli/Osteosarcoma-2 Protocol: An Updated Report

2000 ◽  
Vol 18 (24) ◽  
pp. 4016-4027 ◽  
Author(s):  
Gaetano Bacci ◽  
Stefano Ferrari ◽  
Franco Bertoni ◽  
Pietro Ruggieri ◽  
Piero Picci ◽  
...  
Keyword(s):  
Neoadjuvant Chemotherapy ◽  
Tumor Necrosis ◽  
Poor Responders ◽  
High Dose ◽  
Second Malignancies ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Long Term Follow Up

PURPOSE: To provide an estimate of long-term prognosis for patients with osteosarcoma of the extremity treated in a single institution with neoadjuvant chemotherapy and observed for at least 10 years. PATIENTS AND METHODS: Patients with nonmetastatic osteosarcoma of the extremity were preoperatively treated with high-dose methotrexate, cisplatin, and doxorubicin (ADM). Postoperatively, good responders (90% or more tumor necrosis) received the same three drugs used before surgery, whereas poor responders (less than 90% tumor necrosis) received ifosfamide and etoposide in addition to those three drugs. RESULTS: For the 164 patients who entered the study between September 1986 and December 1989, surgery was a limb salvage in 136 cases (82%) and a good histologic response was observed in 117 patients (71%). At a follow-up ranging from 10 to 13 years (median, 11.5 years), 101 patients (61%) remained continuously free of disease, 61 relapsed, and two died of ADM-induced cardiotoxicity. There were no differences in prognosis between good and poor responding patients. ADM-induced cardiotoxicity (six patients), male infertility (10 of the 12 assessable patients), and second malignancies (seven patients) were the major complications of chemotherapy. Despite the large number of limb salvages performed, only four local recurrences (2.4%) were registered. CONCLUSION: With an aggressive neoadjuvant chemotherapy, it is possible to cure more than 60% of patients with nonmetastatic osteosarcoma of the extremity and amputation may be avoided in more than 80% of them. Because local or systemic relapses, myocardiopathies, and second malignancies are possible even 5 years or more after the beginning of treatment, a long-term follow-up is recommended for these patients.

Long-Term Follow-up of the First Randomized Trial Using Neoadjuvant Chemotherapy in Stage Ib Squamous Carcinoma of the Cervix: The Final Results

1997 ◽  
Vol 67 (1) ◽  
pp. 61-69 ◽  
Author(s):  
Juan E. Sardi ◽  
Adolfo Giaroli ◽  
Carlos Sananes ◽  
Marta Ferreira ◽  
Alejandro Soderini ◽  
...  
Keyword(s):  
Neoadjuvant Chemotherapy ◽  
Randomized Trial ◽  
Squamous Carcinoma ◽  
Stage Ib ◽  
Long Term Follow Up

Long-Term Follow-up of Patients with Stage T1 High-Grade Transitional Cell Carcinoma Managed by Bacille Calmette-Guérin Immunotherapy

Urology ◽  
2007 ◽  
Vol 69 (1) ◽  
pp. 78-82 ◽  
Author(s):  
David Margel ◽  
Raanan Tal ◽  
Shai Golan ◽  
Dani Kedar ◽  
Dov Engelstein ◽  
...  
Keyword(s):  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Transitional Cell ◽  
High Grade ◽  
Bacille Calmette Guerin ◽  
Long Term Follow Up ◽  
Stage T1

The transvenous retrograde pressure cooker technique for the curative embolization of high-grade brain arteriovenous malformations

2020 ◽  
pp. neurintsurg-2020-016566
Author(s):  
Masaomi Koyanagi ◽  
Pascal John Mosimann ◽  
Hannes Nordmeyer ◽  
Markus Heddier ◽  
Juergen Krause ◽  
...  
Keyword(s):  
Arteriovenous Malformations ◽  
High Grade ◽  
Transvenous Embolization ◽  
Cure Rate ◽  
Brain Arteriovenous Malformations ◽  
Long Term Follow Up ◽  
Occlusion Rate ◽  
Grade 3

BackgroundTransvenous embolization of brain arteriovenous malformations (AVMs) can be curative. We aimed to evaluate the cure rate and safety of the transvenous retrograde pressure cooker technique (RPCT) using coils and n-butyl-2-cyanoacrylate as a venous plug.MethodsAll AVM patients treated via transvenous embolization between December 2004 and February 2017 in a single center were extracted from our database. Inclusion criteria were: inability to achieve transarterial cure alone; AVM < 3 cm; and single main draining vein. Outcome measures were immediate and 90 days' angiographic AVM occlusion rate, and morbidity and mortality at 30 days and 12 months, according to the modified Rankin Scale (mRS) score.ResultsFifty-one patients (20 women; median age 47 years) were included. A majority (71%) were high grade (3 to 5 in the Spetzler–Martin classification). AVMs were deeply seated in 30 (59%) and cortical in 21 patients (41%). Thirty-three patients were previously embolized transarterially (65%). All patients but one were cured within a single session with the RPCT (96%). Cure was confirmed on follow-up digital subtraction angiography at 3 months in 82% of patients. Three patients experienced intracranial hemorrhage (6%), one requiring surgical evacuation. There were no deaths. One treatment-related major permanent deficit was observed (2.0%). Mean mRS before treatment, at 30 days, and 12 months after RPCT was 1.5, 1.5, and 1.3, respectively.ConclusionsThe retrograde pressure cooker technique can be curative in carefully selected high-grade AVMs. Long-term follow-up and prospective studies are needed to confirm our results.

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