scholarly journals Histopathological analysis of central nervous system tumor; an observational study

2018 ◽  
Vol 8 (2) ◽  
pp. 1393-1398
Author(s):  
Trishna Kakshapati ◽  
Ranga Bahadur Basnet ◽  
Basant Pant ◽  
Deepti Gautam
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Pituitary Adenoma ◽  
Developed Countries ◽  
Histopathological Analysis ◽  
Central Nervous System Tumor ◽  
Astrocytic Tumor ◽  
Who Grade ◽  
Cns Tumor ◽  
System Tumor

Background:  Though the central nervous system tumor comprises ~2% of all the tumors, an overall increase has been observed especially in less developed countries. This increase in the incidence may be due to exposure of population to various risk factors or improved diagnosis with advancement in the ancillary studies. This study aims to provide a single centre histopathological spectrum of this type of tumor.Materials and Methods: A retrospective cross sectional study on a series of cases was performed in the Department of Pathology, Annapurna Neurological Institute & Allied Science , Maitighar , Kathmandu, Nepal from April 2013 to Jan 2016. Data were analyzed using SPSS version 21.0.Results: A total of 221 brain and CNS tumors (125 females and 96 males) were studied. The mean age at diagnosis was 43.77 years. The most common tumor was meningioma(67 cases, 30.3%), followed by astrocytic tumor (57 cases, 25.7%) and pituitary adenoma(30 cases,13.6%). The frequency of WHO grade I, II,III and IV tumor were 94 cases (55%), 34 cases (19.9%),10 cases (5.8%), and 33 cases (19.3%) respectively. The astrocytic tumor was most frequent tumor in children (7/20 caes, 37 %).Conclusion: This study showed the most common CNS tumor to be meningioma followed by astrocytic tumors and pituitary adenoma. The spectrum of CNS tumor in children showed divergent histologic pattern according to the age. In age group 0-10 years embryonal tumors were common whereas ages group of 12-years showed propensity towards astrocytoma as in adults.  

scholarly journals Tools for the assessment of neuropsychomotor profile in the rehabilitation of children with central nervous system tumor: a systematic review

2019 ◽  
Vol 106 (1) ◽  
pp. 12-24
Author(s):  
Chiara Pellegrini ◽  
Augusto T. Caraceni ◽  
Livia I.E. Bedodi ◽  
Raffaella Sensi ◽  
Simona Breggiè ◽  
...  
Keyword(s):  
Systematic Review ◽  
Central Nervous System ◽  
Nervous System ◽  
Assessment Tools ◽  
Central Nervous System Tumor ◽  
Intelligence Scale ◽  
Cns Tumor ◽  
Rehabilitation Protocols ◽  
System Tumor ◽  
Assessment Procedures

Objective: This study reviews the scientific literature to identify and describe which assessment tools (ATs) are used in pediatric oncology and neuro-oncology rehabilitation and which development neuropsychomotor (DNPM) ATs were built for children with central nervous system (CNS) tumors. Methods: A systematic review was performed searching PubMed, CINAHL, PEDro, Science Direct, and Catalog of National Institute of Tumors databases and specialized journals. The search covered 7 years (2010–2017) and used relevant keywords in different combinations. A further search was carried out on DNPM rehabilitation manuals and academic thesis. Results: The review retrieved 35 eligible articles containing 63 ATs. The most common ATs were the Behavioral Rating Inventory of Executive Function (BRIEF) and the Wechsler Intelligence Scale for Children (WISC). Most of the ATs covered a single area of child development among behavioral/psychological, cognitive, and motor areas. A total of 159 ATs were found in manuals and thesis, and only 17 of them were already identified in the journal search. None of the ATs identified in both searches had been specifically developed for children with CNS tumor. Conclusion: The results highlight the need to develop and validate a global multidimensional AT for children with CNS tumor, overcoming the fragmentation of the assessment procedures and promoting standardized rehabilitation protocols.

scholarly journals Central liponeurocytoma: Case report and review of literature

2012 ◽  
Vol 01 (01) ◽  
pp. 083-085 ◽  
Author(s):  
Pankaj Ailawadhi ◽  
M.C. Sharma ◽  
A.K. Mahapatra ◽  
P. Sarat Chandra
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Tumor Classification ◽  
Central Nervous System Tumor ◽  
The Central Nervous System ◽  
Cerebellar Liponeurocytoma ◽  
Classification Of Tumors ◽  
System Tumor ◽  
Well Differentiated ◽  
Glioneuronal Tumors

Abstract Cerebellar liponeurocytoma consists of well-differentiated neurons with the cytology of neurocytes in addition to a population of lipidized cells. Hence it is biphasic in appearance and has been included in the category of glioneuronal tumors of the central nervous system by the WHO working group on the Classification of Tumors of the Nervous System. However, liponeurocytoma is not exclusive to the cerebellar or fourth ventricular location. Since its inclusion in the central nervous system tumor classification, nine cases with similar histological and immunohistochemical features have also been described in the lateral ventricles. We describe here such a lateral ventricular tumour in a 30-year-old woman, characteristically showing divergent glio-neuronal differentiation and lipidized neoplastic cells. Therefore, we suggest that future WHO tumor classification should consider that liponeurocytomas are not entirely restricted to the cerebellum and henceforth change of nomenclature might be considered, as also pointed out by other authors.

scholarly journals Liaison psychiatry in a central nervous system tumor service

2015 ◽  
Vol 2 (2) ◽  
pp. 88-92
Author(s):  
Alex C.N. Holmes ◽  
Sophia J. Adams ◽  
Scott Hall ◽  
Mark A. Rosenthal ◽  
Katharine J. Drummond
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Neuropsychiatric Symptoms ◽  
Lower Grade ◽  
Central Nervous System Tumor ◽  
Liaison Psychiatry ◽  
Cns Tumor ◽  
Treatment Information ◽  
Psychological Medicine ◽  
The Central Nervous System

AbstractBackgroundTumors of the central nervous system (CNS) have physical and psychological effects that commonly interact and change over time. Although well suited to addressing problems at the interface between physical and psychological medicine, the role of the consultation-liaison psychiatrist has not been previously described in the management of these patients. The purpose of this paper is to summarize the experience of psychiatry liaison attachment within a CNS tumor service and to reflect on its utility within a complex multidisciplinary environment.MethodsA retrospective file review was performed on all cases seen by a psychiatrist in a CNS tumor service over the previous 5 years. A simple thematic inductive analysis was conducted of the common problems experienced by patients and their management by the psychiatrist and within the team.ResultsFive common themes were identified: (i) facilitating adaptation to diagnosis; (ii) supporting living with lower-grade tumors; (iii) managing mental disorders; (iv) neuropsychiatric symptoms of tumor progression; and (v) grief and uncertainty in the advanced stages of illness. The capacity of the psychiatrist to understand and integrate the clinical, pathological, radiological, and treatment information, in communication with colleagues, helped address these challenges.ConclusionsPsychological challenges in CNS tumor patients have both psychological and neurological underpinnings. In our experience, the addition of a liaison psychiatrist to a CNS tumor service was efficient and effective in improving patient management and led to enhanced communication and decision-making within the team.

Hypercoaulability state in central nervous system tumor patients

1997 ◽  
Vol 99 ◽  
pp. S251
Author(s):  
M.E. Kusak ◽  
J.M. Alonso ◽  
D. Santamarta ◽  
I. Recio ◽  
J.M. Borrás ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Central Nervous System Tumor ◽  
Tumor Patients ◽  
System Tumor

Expression of the RAG-2 gene in murine central nervous system tumor cell lines

1991 ◽  
Vol 181 (1) ◽  
pp. 151-158 ◽  
Author(s):  
Kei Tashiro ◽  
Toru Nakano ◽  
Tasuku Honjo ◽  
Tomokazu Aoki ◽  
Shin-ichi Miyatake ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Tumor Cell ◽  
Cell Lines ◽  
Central Nervous System Tumor ◽  
Tumor Cell Lines ◽  
System Tumor

scholarly journals Diagnostic accuracy of squash cytology in central nervous system tumors

2017 ◽  
Vol 20 (1) ◽  
pp. 3-9
Author(s):  
Ram Kumar Shrestha ◽  
Bibek KC ◽  
Gopal Sedain ◽  
Gita Sayami ◽  
Sushil Shilpakar ◽  
...  
Keyword(s):  
Decision Making ◽  
Central Nervous System ◽  
Nervous System ◽  
Diagnostic Accuracy ◽  
Histopathological Examination ◽  
Biological Behavior ◽  
Central Nervous System Tumor ◽  
Quick Method ◽  
System Tumor ◽  
Method Of Evaluation

Introduction: CNS tumor requires intraoperative decision making regarding the extent of tumor removal. Clinical examination and imaging studies are not sufficient enough to predict the biological behavior of the tumors. Squash cytology is a quick method of evaluation of cytomorphologic features prepared from smear technique and provide the preliminary diagnosis and aid in intraoperative decision making by differentiating neoplastic from non neoplastic and benign from malignant lesions. The aim of this study is compare the diagnostic accuracy of squash cytology to that of histopathological examination. Methods: This study consists of 36 specimens from both brain and spine subjected to both squash cytology and histopathological evaluation. The squash preparation and histopathological finding were later compared and diagnostic accuracy calculated. Results: Gliomas are the most common tumor encountered and the accuracy of Squash cytology obtained was 71%. In meningioma, 100% diagnostic accuracy was obtained however, there was limitation in accurately predict the subgroup of tumor by squash cytology alone. Other neoplastic lesions included in this study were Schwannoma, Oligodendroglioma, Ependymoma, mixed tumors and others. Overall, the accuracy predicted by squash cytology is found to be 77.8 % in this study. Conclusion: Squash cytology is rapid and reliable method of tissue diagnosis that aid in intraoperative decision making regarding the extent of Central Nervous System tumor excision

scholarly journals QOL-52. USE OF CANNABINOIDS IN THE PEDIATRIC CENTRAL NERVOUS SYSTEM TUMOR POPULATION

2018 ◽  
Vol 20 (suppl_2) ◽  
pp. i168-i168
Author(s):  
Kathleen Dorris ◽  
Jessica Channell ◽  
Molly Hemenway ◽  
Angelina Baroffio ◽  
Michael Ellison ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Central Nervous System Tumor ◽  
System Tumor
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