scholarly journals Assessment of Prescription Patterns in Hypertensive and Diabetic Patients Visiting Private Tertiary Care Hospital of Dharan Municipality, Nepal

2016 ◽  
Vol 2 (1) ◽  
pp. 44-47 ◽  
Author(s):  
Prasanna Dahal ◽  
Laxman Maharjan ◽  
Bibek Dahal ◽  
Kissan Gupta
Keyword(s):  
Combination Therapy ◽  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Tertiary Care ◽  
Antihypertensive Agents ◽  
Hypoglycemic Agents ◽  
Diabetic Patients ◽  
Channel Blockers ◽  
Care Hospital ◽  
Hypertensive Drug

This study was conducted to assess the drug prescribing trend of anti-hypertensive and hypoglycemic agents in hypertensive and diabetic patients in tertiary care private Hospital. The study was prospective, cross-sectional and observational study. A total of 100 prescriptions were recorded. 56% were males as compared to 44% females. The age group of the patients varied from 30 to 90 years with majority individual above 50 years of age. 59% patients were hypertensive; 26% patients were diabetic and 15% had both the diseases. For the treatment of HTN, both mono-therapy and combination therapy were followed. In mono-therapy, amlodipine was most commonly prescribed followed by losartan. In combination therapy, a two-drug combination consisting of calcium channel blockers (amlodipine) and diuretics (furosemide /hydrochlorothiazide) were given to the majority of patients, followed by Diuretics and Angiotensin receptor blocker combination. Among diabetic hypertensive, 66.67% of patients were treated with single anti-hypertensive drug and 33.35% of patients were treated with anti-hypertensive drug combinations with oral hypoglycemics. This study showed that calcium channel blockers were the most prescribed antihypertensive agents while biguanides were the mostly prescribed among anti-diabetic agents. Combination therapy was observed in a high percentage of prescriptions in hypertensive patients. Prescribing pattern among antihypertensive showed some dubitable adherences to existing evidence-based JNC guidelines.Sunsari Technical College Journal 2015, 2(1):44-47

scholarly journals Patterns of use of drugs in hypertension in geriatric patients in the department of medicine at tertiary care hospital of Nepal.

2020 ◽  
Vol 5 (3) ◽  
pp. 1155-1160
Author(s):  
Binod Raut ◽  
Anjan Khadka
Keyword(s):  
Combination Therapy ◽  
Calcium Channel ◽  
Antihypertensive Drug ◽  
Calcium Channel Blockers ◽  
Geriatric Patients ◽  
Antihypertensive Drugs ◽  
Tertiary Care ◽  
Channel Blockers ◽  
Care Hospital ◽  
Cross Sectional

Introduction: In Nepal, the prevalence of hypertensive in elderly population is 41.7% aged 65 years or more.  Hypertension increases with age leading to arterial stiffness and endothelial dysfunction. The prevalence of hypertension is 20% of urban populations. Blood pressure control with the use of antihypertensive drugs reduces cardiovascular complications in geriatric patients. Objectives: The objective of our study is to know  the various patterns of drugs used in geriatrics hypertensive patient along with their co-morbidities and to know  the most commonly used antihypertensive drug in geriatric patient. Methodology: It was a hospital based cross sectional study involving 130 patients based on non-probability sampling. The study involved the hypertensive elderly patients of age > 65 years prescribed with antihypertensive drugs. Data were collected from patients attending outpatient  department of medicine .    Medical and nursing records were analyzed for patient’s characteristics (e.g. age, gender), systolic and diastolic BP readings, number of drugs, monotherapy, combination therapy, co morbidities. Data were analysed by using SPSS version 20. Results: The total 130 geriatric patients under treatment with antihypertensive drugs were included, in which 55.38% were male and 44.62% were female. The total numbers of antihypertensive drugs prescribed were 212 either as monotherapy or as a component of a combination therapy. The average number of drugs prescribed per patient was found to be 1.66. Among these drugs 56.92% were prescribed as monotherapy,26.92% were prescribed as two drugs combination therapy,12.30% were prescribed as three drugs combination and 3.84% were prescribed as four drugs combination therapy. calcium channel blockers (amlodipine )was the most commonly prescribed antihypertensive. Conclusion: The study showed male patient were more predominant hypertensive compare to female. calcium channel blockers group of drugs in which amlodipine was the most commonly prescribed antihypertensive drug and more than half of the patients were in monotherapy.

scholarly journals DRUG UTILIZATION PATTERN OF ANTIHYPERTENSIVE MEDICATIONS IN A TERTIARY CARE HOSPITAL, SOUTH INDIA

2021 ◽  
pp. 115-118
Author(s):  
ANURADHA VP ◽  
MUHAS C ◽  
ANJALI SRUTHY S
Keyword(s):  
Drug Use ◽  
Combination Therapy ◽  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Angiotensin Receptor Blockers ◽  
Tertiary Care ◽  
Channel Blockers ◽  
Close Monitoring ◽  
Care Hospital ◽  
Antihypertensive Medications

Objective: The objective of the study is to assess drug use pattern of antihypertensive medications in hypertensive patients. Methods: It is a prospective cross-sectional study conducted in the outpatient dispensary, Government Medical College, Thiruvananthapuram for the period of 6 months from January 2019 to June 2019. About 500 prescriptions of patients visiting outpatient dispensary with an antihypertensive prescription were enrolled for the study. Drug use patterns of different classes of antihypertensive medications were analyzed from individual prescriptions. Results: A total of 500 patients were included in this study, among which 281 were male (56.2%) and 219 (43.8%) were female. In 500 patients, 133 patients were treated with monotherapy. In that 42.1% of patients were treated with amlodipine, 28.57% of patients were treated with losartan. In combination therapy most commonly used was double therapy (42.8%) followed by triple therapy (24.2%). Calcium Channel Blockers (56.2%) was most prescribed class of drug followed by Angiotensin Receptor Blockers. Conclusion: This study reveals that calcium channel blockers as most prescribed class of antihypertensive and Amlodipine was the most prescribed antihypertensive. In our study, most of the patients were treated with combination therapy in that double drug therapy was most common. There is a chance of various medication errors, development of adverse drug reaction as majority (290) of patients belong to age above 60 and chances of getting error also increases as combination therapy is most used. Therefore close monitoring is required for such patients.

scholarly journals An Observational Study on Drug Utilization Pattern in Chronic Kidney Disease Patients using Anti-Hypertensive Drugs in a Tertiary Care Teaching Hospital

2021 ◽  
pp. 9-18
Author(s):  
Rajesh Hadia ◽  
Hemraj Singh Rajput ◽  
Vidhi Mehta ◽  
Pushti Shah ◽  
Arti Muley ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Calcium Channel ◽  
Drug Utilization ◽  
Calcium Channel Blockers ◽  
Antihypertensive Drugs ◽  
Tertiary Care ◽  
Antihypertensive Agents ◽  
Channel Blockers ◽  
Utilization Pattern

Background: There is a strong relationship between Hypertension and chronic kidney disease. HTN is highly prevalent in CKD patients, contributing to high cardiovascular risk. Objectives: This study aims drug utilization pattern of Antihypertensive drugs in CKD. The objective of the study to determine the occurrence of co-morbidities, the prevalence of CKD stages in chronic kidney patients and to prepare a protocol of anti-hypertensive in CKD. Methodology: This was an observational/cross-sectional study that was carried out for six months at Dhiraj General Hospital, Vadodara. CKD patients who were prescribed antihypertensive agents were included as per study criteria. Data was collected by filling the patient medical record sheet. Results: A total of 60 CKD patients with HTN were included in the study according to inclusion and exclusion criteria. Out of 60 patients, we noticed that number of inpatients was 67% while the number of OPD patients was just 33%. Comparing gender proportionality, male represents 63% and female represents 37% were found between the age group of 18-65 years. The recorded systolic BP in mild case in the overall study population was found to be 140-159 mmHg and diastolic BP was found to be 90-99 mmHg. In moderate case systolic BP was 160-179 mmHg and diastolic BP was found to be 100-109 mmHg. In severe cases systolic BP was ≥180 mmHg and diastolic BP was found to be ≥110 mmHg. Among antihypertensive Calcium channel blockers was prescribed in 34.18% of patients and mostly recommended drug for hypertensive chronic kidney patients was furosemide which was 19.34%. Most participants were treated with multi-drug therapy. Conclusion: In Hypertensive CKD patients, calcium channel blockers and furosemide were highly recommended which do not diverge from National Kidney Foundation Kidney Disease, Outcome Quality Initiative guidelines.

scholarly journals Adverse drug reactions of antihypertensive agents at tertiary care hospital in central Nepal

2017 ◽  
Vol 13 (2) ◽  
pp. 284-289 ◽  
Author(s):  
Sabita Paudel ◽  
M Sudarsana Chetty ◽  
Shankar Laudari ◽  
Nuwadatta Subedi
Keyword(s):  
Calcium Channel ◽  
Cardiovascular System ◽  
Adverse Drug Reactions ◽  
Calcium Channel Blockers ◽  
Antihypertensive Agents ◽  
Exact Nature ◽  
Channel Blockers ◽  
Care Hospital ◽  
Drug Reactions ◽  
Adrenergic Antagonist

Background & Objectives: Acute Hypertension is the most common condition seen in primary care and leads to myocardial infarction, stroke, renal failure, and death if not detected early and treated appropriately.  The study was conducted with the objective to examine the incidence of different types of adverse drug reactions in drug treated hypertensive patients.Materials & Methods: Patients (n=382) who received antihypertensive agents were selected and interviewed using a standardized questionnaire. The Naranjo Algorithm, which categorizes the causality relationship into definite, probable, possible and doubtful, was used for the assessment of the exact nature of Adverse drug reaction (ADR).Results: Calcium channel blockers (CCBs) were the drug class with highest number (22 or  32.84%)  of ADRs followed by Angiotensin-converting enzyme Inhibitors (ACEI) in 17 (25.38%), Angiotensin Receptor Blockers (ARB) in 12 (17.91%), diuretics in 10 (14.92%) and beta adrenergic antagonist in six (8.95%). Cardiovascular system (40 or 59.70%) was the most affected followed by central nervous system (16 or 23.88%) and respiratory and dermatological system each in 11 (16.42%) cases. On Naranjo’s probability scale, nine (13.4%) of the ADRs were definite, 39 (58.2%) possible, 16 (23.9%) probable and three (4.5%) doubtful.      Conclusion: Calcium channel blockers were mostly associated with ADRs while Cardiovascular system was the most frequently affected. 

scholarly journals Prescription Patterns of Antihypertensive Drugs at Tertiary Care Hospital: A Descriptive Cross Sectional Study

2020 ◽  
Vol 9 (1) ◽  
pp. 22-26
Author(s):  
Kamal Sharma Lamsal ◽  
Keshav Raj Neupane ◽  
Rajati Sharma Kafle
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Tertiary Care Hospital ◽  
Angiotensin Receptor Blockers ◽  
Tertiary Care ◽  
Channel Blockers ◽  
Care Hospital ◽  
Thiazide Diuretics ◽  
Angiotensin Receptor ◽  
Receptor Blockers

Background: Hypertension is leading cause of deaths in the world. It is a modifiable and major risk factor for cardiovascular, renal and brain diseases. This study was done to see the current trend of prescription patterns of antihypertensive drugs in a tertiary care hospital in Nepal. Materials and Methods: Observational cross sectional study was done in the patients with hypertension from September 2018 to September 2019 in the department of Medicine of Civil Service Hospital, a tertiary care hospital in Kathmandu, Nepal. A total of 242 Patients who were undergoing antihypertensive treatment were included. All calculations and statistical analyses are processed by the SPSS 25.0. Results: Out of 242 prescriptions, 135(55.8%) were males, and 107(44.2%) were females. Among them, 49 (20.2%) patients had controlled Blood Pressure, 63(26%) patients had hypertension stage I and the remaining 130 patients (53.7%) patients had stage II hypertension. In the present study, 133 (54.96%) were treated with monotherapy while, 71 (29.33%) patients were prescribed with dual therapy. The most frequently prescribed drug as monotherapy was Calcium Channel Blocker in 71(53.3%) patients followed by Angiotensin Receptor Blockers in 38 (28.6%) and thiazide diuretics in 21 (15.7%) patients. Calcium Channel Blockers with Angiotensin Receptor Blockers was the most prescribed combination in 44 (62.1%) patients followed by Angiotensin Receptor Blockers and Thiazide Diuretics in 19 (26.8%) patients. Conclusion: Calcium channel blockers are the highest among the drugs that are used as monotherapy. In combination therapy, Calcium channel blockers with angiotensin receptor blocker and angiotensin receptor blockers with thiazide diuretics are the frequently prescribed drugs.

scholarly journals Study on drug utilization pattern of antihypertensive medication in tertiary care hospital of Telangana, India

2018 ◽  
Vol 7 (9) ◽  
pp. 1770
Author(s):  
K. Vashishta
Keyword(s):  
Calcium Channel ◽  
Drug Utilization ◽  
Calcium Channel Blockers ◽  
Antihypertensive Medication ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Utilization Review ◽  
Channel Blockers ◽  
Care Hospital ◽  
Utilization Pattern

Background: Hypertension is leading cause of deaths in the world. It is the major risk factor for systemic disorders including cardiovascular, renal and brain disorders. A drug utilization review on antihypertensive drugs should be done to determine different classes of antihypertensive medications with respect to diagnosis. Aim was to study drug utilization pattern of antihypertensive medication in a tertiary care hospital, Telangana.Methods: A cross sectional observational study was done in the patients with hypertension for duration of one year i.e. from April 2017 to May 2018 in the department of Pharmacology at Mallareddy Narayana multispecialty hospital, suraram, Telangana. A total 130 Patients who were suffering with acute, chronic hypertension and admitted in general medicine department and undergoing antihypertensive treatment were included.Results: A Total of 130 patients with history of hypertension were included. majority of patients i.e., 46.1% (60/130) were among 51-60 years, followed by 24.6% (32/130) patients among 41-50 years., Male predominance 80/130 61.5%) compared to females 50/130 (38.4%). In the Present study, 105(80.7%) prescriptions had Monotherapy prescription and 25/130 (19.2%) has combination of two. The most frequently prescribed drug as monotherapy was Calcium Channel Blockers (CCBs) about 52.3%, Beta blockers constitute about 14.2%, and diuretics about 19%, 9.5% Angiotension Receptor Blockers (ARBs) and alpha-Adrenergic Blocker (AABs), 4.7% ACE inhibitors.Conclusions: Calcium channel blockers are the highest among the drugs that are used as monotherapy. In combination therapy, diuretic with angiotensin receptor blocker and calcium channel blocker with beta blocker are the frequently prescribed drugs.

scholarly journals DRUG UTILIZATION BASED ADRS MONITORING OF ANTIHYPERTENSIVE AGENTS PRESCRIBED IN AL-QUWAYIYAH GENERAL HOSPITAL, SAUDI ARABIA

2018 ◽  
Vol 10 (3) ◽  
pp. 22
Author(s):  
Md Salahuddin Ansari ◽  
Faisal Al-otaibi
Keyword(s):  
Saudi Arabia ◽  
Calcium Channel ◽  
General Hospital ◽  
Drug Utilization ◽  
Calcium Channel Blockers ◽  
Antihypertensive Drugs ◽  
Antihypertensive Agents ◽  
Channel Blockers ◽  
Hypertensive Patients ◽  
Patient Interviews

Objective: To monitor drug utilization based adverse drug reactions (ADRs) of antihypertensive agents prescribed in Al-Quwayiyah general hospital, Saudi Arabia.Methods: An open, non-comparative, observational study was conducted on hypertensive patients attending the medicine outpatient department of Al-Quwayyah general hospital, Al-Quwayyah, Saudi arabia. Data were collected by conducting patient interviews. Data were captured for adverse drug reaction monitoring based on Narinjo scale and WHO format.Results: 25 ADRs were observed out of 212 hypertensive patients. Incidence was found to be higher in patients more than 40 y age, and females experienced more ADRs (n = 16, 7.54%) than males, 9 (4.62%). Combination therapy was associated with more number of ADRs (64.0%) as against monotherapy (36.0%). Calcium channel blockers were found to be the most frequently associated drugs with ADRs (n = 8), followed by diuretics (n = 6), and β-blockers (n = 5). Among individual drugs, amlodipine was found to be the commonest drug associated with ADRs (n = 8), followed by torasemide (n = 4). ADRs associated with the central nervous system was found to be the most frequent (48.0%) followed by musculoskeletal complaints (20.0%) and respiratory system disorders (16.0%).Conclusion: ADRs were experienced by taking the antihypertensive drugs prescribed in Al-Quwayyah general hospital, Saudi arabia. The findings would be useful for physicians in rational prescribing. Calcium channel blockers were found to be the most frequently associated drugs with ADRs.

scholarly journals An observational cross-sectional study to determine the effect of telmisartan on reducing microalbuminuria in diabetic hypertensive patients in tertiary care teaching hospital, Central India

2017 ◽  
Vol 6 (8) ◽  
pp. 2082
Author(s):  
Santenna Chenchula ◽  
Rupesh Gupta ◽  
Balakrishnan S. ◽  
Akash Vishwe ◽  
Pushparaj Gour ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Angiotensin Receptor Blockers ◽  
Tertiary Care ◽  
Channel Blockers ◽  
Angiotensin Receptor ◽  
Cross Sectional ◽  
Hypertensive Patients ◽  
Urine Albumin ◽  
Receptor Blockers

Background: There are many groups of drugs to decrease microalbuminuria like angiotensin converting enzyme inhibitors (ACEI), angiotensin receptor blockers (ARBs), calcium channel blockers and direct vasodilators. Among these, ACEI and ARBs are commonly used for this purpose. If side effects occur, ACEI are replaced with ARBs. Many ARBs have been studied for their effect on reducing microalbuminuria, but data on telmisartan with its additional unique properties are scarce in Indian population.Methods: This cross sectional observational study was carried out in a tertiary care centre. We first measured base line urine albumin levels in included patients, 3 months after treatment with telmisartan using ‘hemocue urine albumin analyser’. We collected and compared both baseline and after treatment data of microalbuminuria and analysed in descriptive statistics.Results: A total of 110 patients participated in this study; out of which 10 patients were excluded from the study because they were not available for follow up. As compared to baseline, urine albumin level decreased by 30.42% after 12 weeks treatment with telmisartan (P <0.001).Conclusions: Microalbuminuria is one of the leading cause of end stage renal disease and coronary heart diseases in diabetic hypertensive patients. Drugs like ACE inhibitors, Angiotensin receptor blockers, Calcium channel blockers and direct vasodilators are used to prevent these complications. In this present study, we concluded that telmisartan decreases urine albumin excretion around 30.42% from baseline after 12 weeks of treatment.

Dihydropyrimidine calcium channel blockers. 4. Basic 3-substituted-4-aryl-1,4-dihydropyrimidine-5-carboxylic acid esters. Potent antihypertensive agents

1992 ◽  
Vol 35 (17) ◽  
pp. 3254-3263 ◽  
Author(s):  
George C. Rovnyak ◽  
Karnail S. Atwal ◽  
Anders Hedberg ◽  
S. David Kimball ◽  
Suzanne Moreland ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Antihypertensive Agents ◽  
Channel Blockers ◽  
Acid Esters
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