DRUG UTILIZATION PATTERN OF ANTIHYPERTENSIVE MEDICATIONS IN A TERTIARY CARE HOSPITAL, SOUTH INDIA

Objective: The objective of the study is to assess drug use pattern of antihypertensive medications in hypertensive patients. Methods: It is a prospective cross-sectional study conducted in the outpatient dispensary, Government Medical College, Thiruvananthapuram for the period of 6 months from January 2019 to June 2019. About 500 prescriptions of patients visiting outpatient dispensary with an antihypertensive prescription were enrolled for the study. Drug use patterns of different classes of antihypertensive medications were analyzed from individual prescriptions. Results: A total of 500 patients were included in this study, among which 281 were male (56.2%) and 219 (43.8%) were female. In 500 patients, 133 patients were treated with monotherapy. In that 42.1% of patients were treated with amlodipine, 28.57% of patients were treated with losartan. In combination therapy most commonly used was double therapy (42.8%) followed by triple therapy (24.2%). Calcium Channel Blockers (56.2%) was most prescribed class of drug followed by Angiotensin Receptor Blockers. Conclusion: This study reveals that calcium channel blockers as most prescribed class of antihypertensive and Amlodipine was the most prescribed antihypertensive. In our study, most of the patients were treated with combination therapy in that double drug therapy was most common. There is a chance of various medication errors, development of adverse drug reaction as majority (290) of patients belong to age above 60 and chances of getting error also increases as combination therapy is most used. Therefore close monitoring is required for such patients.

Download Full-text

Patterns of use of drugs in hypertension in geriatric patients in the department of medicine at tertiary care hospital of Nepal.

Birat Journal of Health Sciences ◽

10.3126/bjhs.v5i3.33685 ◽

2020 ◽

Vol 5 (3) ◽

pp. 1155-1160

Author(s):

Binod Raut ◽

Anjan Khadka

Keyword(s):

Combination Therapy ◽

Calcium Channel ◽

Antihypertensive Drug ◽

Calcium Channel Blockers ◽

Geriatric Patients ◽

Antihypertensive Drugs ◽

Tertiary Care ◽

Channel Blockers ◽

Care Hospital ◽

Cross Sectional

Introduction: In Nepal, the prevalence of hypertensive in elderly population is 41.7% aged 65 years or more. Hypertension increases with age leading to arterial stiffness and endothelial dysfunction. The prevalence of hypertension is 20% of urban populations. Blood pressure control with the use of antihypertensive drugs reduces cardiovascular complications in geriatric patients. Objectives: The objective of our study is to know the various patterns of drugs used in geriatrics hypertensive patient along with their co-morbidities and to know the most commonly used antihypertensive drug in geriatric patient. Methodology: It was a hospital based cross sectional study involving 130 patients based on non-probability sampling. The study involved the hypertensive elderly patients of age > 65 years prescribed with antihypertensive drugs. Data were collected from patients attending outpatient department of medicine . Medical and nursing records were analyzed for patient’s characteristics (e.g. age, gender), systolic and diastolic BP readings, number of drugs, monotherapy, combination therapy, co morbidities. Data were analysed by using SPSS version 20. Results: The total 130 geriatric patients under treatment with antihypertensive drugs were included, in which 55.38% were male and 44.62% were female. The total numbers of antihypertensive drugs prescribed were 212 either as monotherapy or as a component of a combination therapy. The average number of drugs prescribed per patient was found to be 1.66. Among these drugs 56.92% were prescribed as monotherapy,26.92% were prescribed as two drugs combination therapy,12.30% were prescribed as three drugs combination and 3.84% were prescribed as four drugs combination therapy. calcium channel blockers (amlodipine )was the most commonly prescribed antihypertensive. Conclusion: The study showed male patient were more predominant hypertensive compare to female. calcium channel blockers group of drugs in which amlodipine was the most commonly prescribed antihypertensive drug and more than half of the patients were in monotherapy.

Download Full-text

Assessment of Prescription Patterns in Hypertensive and Diabetic Patients Visiting Private Tertiary Care Hospital of Dharan Municipality, Nepal

Sunsari Technical College Journal ◽

10.3126/stcj.v2i1.14798 ◽

2016 ◽

Vol 2 (1) ◽

pp. 44-47 ◽

Cited By ~ 2

Author(s):

Prasanna Dahal ◽

Laxman Maharjan ◽

Bibek Dahal ◽

Kissan Gupta

Keyword(s):

Combination Therapy ◽

Calcium Channel ◽

Calcium Channel Blockers ◽

Tertiary Care ◽

Antihypertensive Agents ◽

Hypoglycemic Agents ◽

Diabetic Patients ◽

Channel Blockers ◽

Care Hospital ◽

Hypertensive Drug

This study was conducted to assess the drug prescribing trend of anti-hypertensive and hypoglycemic agents in hypertensive and diabetic patients in tertiary care private Hospital. The study was prospective, cross-sectional and observational study. A total of 100 prescriptions were recorded. 56% were males as compared to 44% females. The age group of the patients varied from 30 to 90 years with majority individual above 50 years of age. 59% patients were hypertensive; 26% patients were diabetic and 15% had both the diseases. For the treatment of HTN, both mono-therapy and combination therapy were followed. In mono-therapy, amlodipine was most commonly prescribed followed by losartan. In combination therapy, a two-drug combination consisting of calcium channel blockers (amlodipine) and diuretics (furosemide /hydrochlorothiazide) were given to the majority of patients, followed by Diuretics and Angiotensin receptor blocker combination. Among diabetic hypertensive, 66.67% of patients were treated with single anti-hypertensive drug and 33.35% of patients were treated with anti-hypertensive drug combinations with oral hypoglycemics. This study showed that calcium channel blockers were the most prescribed antihypertensive agents while biguanides were the mostly prescribed among anti-diabetic agents. Combination therapy was observed in a high percentage of prescriptions in hypertensive patients. Prescribing pattern among antihypertensive showed some dubitable adherences to existing evidence-based JNC guidelines.Sunsari Technical College Journal 2015, 2(1):44-47

Download Full-text

Prescription Patterns of Antihypertensive Drugs at Tertiary Care Hospital: A Descriptive Cross Sectional Study

Journal of Nobel Medical College ◽

10.3126/jonmc.v9i1.29462 ◽

2020 ◽

Vol 9 (1) ◽

pp. 22-26

Author(s):

Kamal Sharma Lamsal ◽

Keshav Raj Neupane ◽

Rajati Sharma Kafle

Keyword(s):

Calcium Channel ◽

Calcium Channel Blockers ◽

Tertiary Care Hospital ◽

Angiotensin Receptor Blockers ◽

Tertiary Care ◽

Channel Blockers ◽

Care Hospital ◽

Thiazide Diuretics ◽

Angiotensin Receptor ◽

Receptor Blockers

Background: Hypertension is leading cause of deaths in the world. It is a modifiable and major risk factor for cardiovascular, renal and brain diseases. This study was done to see the current trend of prescription patterns of antihypertensive drugs in a tertiary care hospital in Nepal. Materials and Methods: Observational cross sectional study was done in the patients with hypertension from September 2018 to September 2019 in the department of Medicine of Civil Service Hospital, a tertiary care hospital in Kathmandu, Nepal. A total of 242 Patients who were undergoing antihypertensive treatment were included. All calculations and statistical analyses are processed by the SPSS 25.0. Results: Out of 242 prescriptions, 135(55.8%) were males, and 107(44.2%) were females. Among them, 49 (20.2%) patients had controlled Blood Pressure, 63(26%) patients had hypertension stage I and the remaining 130 patients (53.7%) patients had stage II hypertension. In the present study, 133 (54.96%) were treated with monotherapy while, 71 (29.33%) patients were prescribed with dual therapy. The most frequently prescribed drug as monotherapy was Calcium Channel Blocker in 71(53.3%) patients followed by Angiotensin Receptor Blockers in 38 (28.6%) and thiazide diuretics in 21 (15.7%) patients. Calcium Channel Blockers with Angiotensin Receptor Blockers was the most prescribed combination in 44 (62.1%) patients followed by Angiotensin Receptor Blockers and Thiazide Diuretics in 19 (26.8%) patients. Conclusion: Calcium channel blockers are the highest among the drugs that are used as monotherapy. In combination therapy, Calcium channel blockers with angiotensin receptor blocker and angiotensin receptor blockers with thiazide diuretics are the frequently prescribed drugs.

Download Full-text

An observational cross-sectional study to determine the effect of telmisartan on reducing microalbuminuria in diabetic hypertensive patients in tertiary care teaching hospital, Central India

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20173300 ◽

2017 ◽

Vol 6 (8) ◽

pp. 2082

Author(s):

Santenna Chenchula ◽

Rupesh Gupta ◽

Balakrishnan S. ◽

Akash Vishwe ◽

Pushparaj Gour ◽

...

Keyword(s):

Calcium Channel ◽

Calcium Channel Blockers ◽

Angiotensin Receptor Blockers ◽

Tertiary Care ◽

Channel Blockers ◽

Angiotensin Receptor ◽

Cross Sectional ◽

Hypertensive Patients ◽

Urine Albumin ◽

Receptor Blockers

Background: There are many groups of drugs to decrease microalbuminuria like angiotensin converting enzyme inhibitors (ACEI), angiotensin receptor blockers (ARBs), calcium channel blockers and direct vasodilators. Among these, ACEI and ARBs are commonly used for this purpose. If side effects occur, ACEI are replaced with ARBs. Many ARBs have been studied for their effect on reducing microalbuminuria, but data on telmisartan with its additional unique properties are scarce in Indian population.Methods: This cross sectional observational study was carried out in a tertiary care centre. We first measured base line urine albumin levels in included patients, 3 months after treatment with telmisartan using ‘hemocue urine albumin analyser’. We collected and compared both baseline and after treatment data of microalbuminuria and analysed in descriptive statistics.Results: A total of 110 patients participated in this study; out of which 10 patients were excluded from the study because they were not available for follow up. As compared to baseline, urine albumin level decreased by 30.42% after 12 weeks treatment with telmisartan (P <0.001).Conclusions: Microalbuminuria is one of the leading cause of end stage renal disease and coronary heart diseases in diabetic hypertensive patients. Drugs like ACE inhibitors, Angiotensin receptor blockers, Calcium channel blockers and direct vasodilators are used to prevent these complications. In this present study, we concluded that telmisartan decreases urine albumin excretion around 30.42% from baseline after 12 weeks of treatment.

Download Full-text

Combination Therapy in Hypertension: A Focus on Angiotensin Receptor Blockers and Calcium Channel Blockers

American Journal of Therapeutics ◽

10.1097/mjt.0b013e31815db6c0 ◽

2010 ◽

Vol 17 (1) ◽

pp. 61-67 ◽

Cited By ~ 2

Author(s):

Naga Meka ◽

Srikanth Katragadda ◽

Biju Cherian ◽

Rohit R Arora

Keyword(s):

Combination Therapy ◽

Calcium Channel ◽

Calcium Channel Blockers ◽

Angiotensin Receptor Blockers ◽

Channel Blockers ◽

Angiotensin Receptor ◽

Receptor Blockers

Download Full-text

Study on drug utilization pattern of antihypertensive medication in tertiary care hospital of Telangana, India

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20183487 ◽

2018 ◽

Vol 7 (9) ◽

pp. 1770

Author(s):

K. Vashishta

Keyword(s):

Calcium Channel ◽

Drug Utilization ◽

Calcium Channel Blockers ◽

Antihypertensive Medication ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Utilization Review ◽

Channel Blockers ◽

Care Hospital ◽

Utilization Pattern

Background: Hypertension is leading cause of deaths in the world. It is the major risk factor for systemic disorders including cardiovascular, renal and brain disorders. A drug utilization review on antihypertensive drugs should be done to determine different classes of antihypertensive medications with respect to diagnosis. Aim was to study drug utilization pattern of antihypertensive medication in a tertiary care hospital, Telangana.Methods: A cross sectional observational study was done in the patients with hypertension for duration of one year i.e. from April 2017 to May 2018 in the department of Pharmacology at Mallareddy Narayana multispecialty hospital, suraram, Telangana. A total 130 Patients who were suffering with acute, chronic hypertension and admitted in general medicine department and undergoing antihypertensive treatment were included.Results: A Total of 130 patients with history of hypertension were included. majority of patients i.e., 46.1% (60/130) were among 51-60 years, followed by 24.6% (32/130) patients among 41-50 years., Male predominance 80/130 61.5%) compared to females 50/130 (38.4%). In the Present study, 105(80.7%) prescriptions had Monotherapy prescription and 25/130 (19.2%) has combination of two. The most frequently prescribed drug as monotherapy was Calcium Channel Blockers (CCBs) about 52.3%, Beta blockers constitute about 14.2%, and diuretics about 19%, 9.5% Angiotension Receptor Blockers (ARBs) and alpha-Adrenergic Blocker (AABs), 4.7% ACE inhibitors.Conclusions: Calcium channel blockers are the highest among the drugs that are used as monotherapy. In combination therapy, diuretic with angiotensin receptor blocker and calcium channel blocker with beta blocker are the frequently prescribed drugs.

Download Full-text