The role of thrombophilia in patients with retinal vein occlusion and no systemic risk factors

2010 ◽  
Vol 45 (2) ◽  
pp. 171-175 ◽  
Author(s):  
Matus Rehak ◽  
Vera Krcova ◽  
Ludek Slavik ◽  
Evzen Fric ◽  
Katerina Langova ◽  
...  
Keyword(s):  
Risk Factors ◽  
Retinal Vein Occlusion ◽  
Systemic Risk ◽  
Vein Occlusion ◽  
Systemic Risk Factors

Prevalence and Systemic Risk Factors for Retinal Vein Occlusion in a General Japanese Population: The Hisayama Study

2010 ◽  
Vol 51 (6) ◽  
pp. 3205 ◽  
Author(s):  
Miho Yasuda ◽  
Yutaka Kiyohara ◽  
Satoshi Arakawa ◽  
Yasuaki Hata ◽  
Koji Yonemoto ◽  
...  
Keyword(s):  
Risk Factors ◽  
Retinal Vein Occlusion ◽  
Systemic Risk ◽  
Japanese Population ◽  
General Japanese Population ◽  
Vein Occlusion ◽  
Systemic Risk Factors

Retinal vein occlusion: an approach to diagnosis, systemic risk factors and management

2008 ◽  
Vol 38 (12) ◽  
pp. 904-910 ◽  
Author(s):  
J. W. Y. Yau ◽  
P. Lee ◽  
T. Y. Wong ◽  
J. Best ◽  
A. Jenkins
Keyword(s):  
Risk Factors ◽  
Retinal Vein Occlusion ◽  
Systemic Risk ◽  
Vein Occlusion ◽  
Systemic Risk Factors

Atherosclerosis at arterial bifurcations: evidence for the role of haemodynamics and geometry

2016 ◽  
Vol 115 (03) ◽  
pp. 484-492 ◽  
Author(s):  
Umberto Morbiducci ◽  
Annette M. Kok ◽  
Brenda R. Kwak ◽  
Peter H. Stone ◽  
David A. Steinman ◽  
...  
Keyword(s):  
Risk Factors ◽  
Shear Stress ◽  
Systemic Risk ◽  
Biological Response ◽  
Arterial System ◽  
Ample Evidence ◽  
Fluid Forces ◽  
Flow Features ◽  
Systemic Risk Factors

SummaryAtherosclerotic plaques are found at distinct locations in the arterial system, despite the exposure to systemic risk factors of the entire vascular tree. From the study of arterial bifurcation regions, emerges ample evidence that haemodynamics are involved in the local onset and progression of the atherosclerotic disease. This observed co-localisation of disturbed flow regions and lesion prevalence at geometrically predisposed districts such as arterial bifurcations has led to the formulation of a ‘haemodynamic hypothesis’, that in this review is grounded to the most current research concerning localising factors of vascular disease. In particular, this review focuses on carotid and coronary bifurcations because of their primary relevance to stroke and heart attack. We highlight reported relationships between atherosclerotic plaque location, progression and composition, and fluid forces at vessel’s wall, in particular shear stress and its ‘easier-tomeasure’ surrogates, i.e. vascular geometric attributes (because geometry shapes the flow) and intravascular flow features (because they mediate disturbed shear stress), in order to give more insight in plaque initiation and destabilisation. Analogous to Virchow’s triad for thrombosis, atherosclerosis must be thought of as subject to a triad of, and especially interactions among, haemodynamic forces, systemic risk factors, and the biological response of the wall.

Impaired fibrinolysis in retinal vein occlusion: a role for genetic determinants of PAI-1 levels

2004 ◽  
Vol 92 (07) ◽  
pp. 54-60 ◽  
Author(s):  
Rossella Marcucci ◽  
Cinzia Fatini ◽  
Francesca Gensini ◽  
Elena Sticchi ◽  
Andrea Sodi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Multivariate Analysis ◽  
Risk Factor ◽  
Retinal Vein Occlusion ◽  
Smoking Habit ◽  
Activity Levels ◽  
Vein Occlusion ◽  
Increased Risk ◽  
Pai 1

SummaryFew and contrasting data are available on the presence of a thrombophilic state in patients with retinal vein occlusion (RVO), and we have previously demonstrated a role of elevated PAI-1 activity as a risk factor for this condition. The present study was undertaken to investigate whether PAI 4G/5G and ACE I/D polymorphisms are independent risk factors for RVO and whether they account for elevated PAI-1 activity levels. We studied 112 RVO patients (52 males and 60 females; range 18–83 years; median age 60 years) and 112 healthy subjects (52 males and 60 females; range 20–84 years; median age 57 years). PAI-1 activity was determined by a chromogenic assay and ACE I/D and PAI-1 4G/5G polymorphisms by polymerase chain reaction (PCR) and restriction length fragment polymorphism (RLFP) methods. Elevated PAI-1 activity (above 95th percentile of the controls) was significantly associated with RVO at multivariate analysis after adjustment for age, sex, traditional cardiovascular risk factors and haemostasis-related risk factors (OR = 4.93, 95% CI 1.70–14.30; p = 0.003).The homozygosity for ACE DD was found to be an independent risk factor for RVO at multivariate analysis (OR = 1.98, 95% CI 1.013.83; p = 0.049), whereas no significant association between homozygosity for PAI-1 4G4G and risk of RVO was observed. Subjects carrying both ACE DD genotype and PAI-1 4G4G genotype showed an increased risk for RVO at multivariate analysis (OR = 4.82, 95% CI 1.89–12.29; p = 0.001). In 45/112 patients without the established risk factors for RVO (hypertension, hypercholesterolemia and diabetes) or characteristics known to be associated to increased PAI-1 activity (overweight, hypertriglyceridemia, and smoking habit) the contemporary presence of ACE DD and PAI-1 4G4G genotype was significantly associated with a risk for RVO (OR = 8.26, 95% CI 1.1857.92; p = 0.034). In conclusion, in our study: 1-indicates that ACE DD genotype is a risk factor for RVO in the whole group of patients, and in the subgroup of patients without the established risk factors for RVO or characteristics influencing the PAI-1 activity, when associated to PAI-1 4G4G genotype, and 2-confirms the role of hypofibrinolysis, documented by high levels of PAI-1 activity, in the occurrence of patients with RVO.

scholarly journals Erratum to: The Role of Systemic Risk Factors in Diabetic Retinopathy

2017 ◽  
Vol 5 (3) ◽  
pp. 270-270
Author(s):  
Elizabeth Atchison ◽  
Andrew Barkmeier
Keyword(s):  
Risk Factors ◽  
Diabetic Retinopathy ◽  
Systemic Risk ◽  
Systemic Risk Factors

scholarly journals Systemic risk factors for retinal vein occlusion in young and middle-aged patients

2019 ◽  
Vol 24 (6) ◽  
pp. 666-673
Author(s):  
Yu. S. Astakhov, ◽  
A. I. Titarenko ◽  
S. N. Tultseva ◽  
S. Yu. Astakhov ◽  
Yu. V. Takhtaev ◽  
...  
Keyword(s):  
Risk Factors ◽  
Retinal Vein Occlusion ◽  
Systemic Risk ◽  
Multidisciplinary Approach ◽  
Middle Aged ◽  
Aged Patients ◽  
Vein Occlusion ◽  
Independent Risk Factors ◽  
Aged Subjects ◽  
Retinal Disorder

Retinal vein occlusion (RVO) is an acute vascular retinal disorder, which is associated with local or general endothelial dysfunction. Up to 25 % of RVO cases occur in young and middle-aged patients. The article reviews possible causes of RVO in young and middle-aged subjects. The authors pay attention to independent risk factors for RVO including arterial hypertension, dyslipidemia, diabetes mellitus and acquired and hereditary thrombophilia. Considering a multifactorial origin of RVO, the authors emphasize the need for a multidisciplinary approach in the management of patients with RVO.

High Prevalence of Hyperhomocysteine in Retinal Vein Occlusion.

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 1617-1617
Author(s):  
Berardino Pollio ◽  
Grazia Delios ◽  
Marco Ladetto ◽  
Marco Tucciarone ◽  
Francesco Di Bassiano ◽  
...  
Keyword(s):  
Risk Factors ◽  
Retinal Vein Occlusion ◽  
Factor V Leiden ◽  
Protein S ◽  
Factor V ◽  
Thrombotic Risk ◽  
Vein Occlusion ◽  
Prothrombin Gene Mutation ◽  
Prothrombin Gene

Abstract Retinal vein occlusion (RVO) is a common cause of blindness. Despite its clinical relevance, the role of inherited thrombophilia in RVO is controversial (Janssen MC et al., Thrombosis and Haemostasis2005; 93). Although many authors consider more important the role of anatomical conditions of lamina cribrosa rather than hypercoagulability in pathogenesis of this disease, the use of antithrombotic drugs for treatment of RVO is widespread (Prisco D et al., Pathophysiology of Haemostasis and Thrombosis2002;32). To evaluate the most important thrombotic risk factors, we collected the data of 80 consecutive patients referred to our Centers for a RVO confirmed by fluoroangiography. Our cohort includes 39 women and 41 men with median age of 66 years; we observed 42 central retinal vein occlusions (CRVO) and 38 branch retinal vein occlusions (BRVO) from March 2002 to July 2005. We collected the following data about cardiovascular risk factors: the prevalence of arterial hypertension was 47,5% (38/80), dyslipidemia 22.5% (18/80), obesity 7.5% (6/80), diabetes mellitus 10% (8/80). Forty-four patients (55%) demonstrated one or more atherosclerotic risk factors. The prevalence of acquired conditions did not show any statistical difference between CRVO and BRVO patients. Moreover we tested fasting homocysteine in 60 patients detecting hyperhomocysteine (defined as a value of homocysteine above 95° percentile of laboratory control group) in 19 cases (31%). Only one patient showed Lupus Anticoagulant and anticardiolipin antibody positivity. Moreover we registered a CRVO during tamoxifen treatment and another one during hormonal therapy. When we considered venous thrombophilia (hormonal therapy, neoplasia, immobilization, surgery, hyperhomocysteine, LAC) we found 25 patients (31.3%) having one or more acquired thrombotic risk factors. Besides, all patients were tested for: antithrombin III, protein C and protein S, activated protein C resistance, factor V Leiden and prothrombin G20210A. We found the presence of genetic trombophilia in 14 patients (17,5%): nine patients had protein S deficit; five had prothrombin gene mutation and one patient had factor V Leiden and one had factor XII deficit (two patients had multiple defects). Results of our survey confirme that acquired risk factors have a more relevant role that genetic thrombophilia in OVR. To draw a conclusion, extensive screening of genetic thrombophilia is not cost-effective in RVO but detection of plasmatic homocysteine concentration can be useful because high frequency of hyperhomocysteine and the possibility of treatment with vitamin B12 and folic acid. Finally we are surprised to see high frequency of protein S deficit in our cohort. Clinical features of 80 retinal vein thrombosis Number of patients: 80 Male/female: 41/39 Median age: 66 Date of recruitment March 2002 -July 2005 Branch retinal vein occlusion 38/80 Central retinal vein occlusion 42/80 Thrombotic risk factors in RVO Hyperhomocysteine 19/60 (31.6%) Genetic thrombophilia 14/80 (17.5%) Protein S deficit 9/80 (11.25%) Prothrombin gene mutation 5/80 (6.3%) Acquired venous risk factors 25/80 (31.3%) Atherosclerotic risk factors 44/80 (55%)

scholarly journals The Role of Systemic Risk Factors in Diabetic Retinopathy

2016 ◽  
Vol 4 (2) ◽  
pp. 84-89 ◽  
Author(s):  
Elizabeth Atchison ◽  
Andrew Barkmeier
Keyword(s):  
Risk Factors ◽  
Diabetic Retinopathy ◽  
Systemic Risk ◽  
Systemic Risk Factors

Retinal Vascular Occlusive Disorders - Risk Factors

2018 ◽  
Vol 3 (02) ◽  
Author(s):  
Shivcharan Lal Chandravanshi, Sunil Kumar Shrivastava, Priyanka Agnihotri, Smriti Gupta
Keyword(s):  
Risk Factors ◽  
Retinal Vein Occlusion ◽  
Central Retinal Vein Occlusion ◽  
Branch Retinal Vein Occlusion ◽  
Retinal Artery Occlusion ◽  
Artery Occlusion ◽  
Vein Occlusion ◽  
Department Of Ophthalmology ◽  
Retinal Artery ◽  
Central Retinal Vein

Aims and Objective - The aim of the present study is to identify risk factors associated with different retinal vascular occlusive diseases (RVOD), such as central retinal artery occlusion (CRAO), hemi-retinal artery occlusion (HRAO), branch retinal artery occlusion (BRAO), cilioretinal artery occlusion (Cilio-RAO), central retinal vein occlusion (CRVO), branch retinal vein occlusion (BRVO), and hemi-retinal vein occlusion (HRVO). Patients and Method - A cross-sectional study on 114 consecutive subjects, aged 24-96 years who have attended at the outpatient department of ophthalmology at Shyam Shah Medical College, Rewa, MP, were included in the study. The Duration of study was January 2016 to December 2017. Only patients with CRAO, BRAO, HRAO, Cilio-RAO, CRVO, BRVO, and HRVO were included in the study. Other retinal vascular disorders such as diabetic vaso-occlusive disease, anterior and posterior ischemic and non-ischemic neuropathy, hypertensive retinopathy, sickle cell retinopathy, retinal telangiectasia, retinopathy of prematurity, were excluded from study. Results - We have included 114 patients, 64 cases (56.14%) males, 50 (43.85%) females, aged 56+/-8 years (range 24-96 years).  Bilateral retinal vascular occlusive disorders were seen in only 4 cases (3.5%). Two patients have bilateral CRVO followed by one case of bilateral BRVO and one case of bilateral CRAO.  Out of 114 patients, branch retinal vein occlusion was seen in 62 cases (54.38%), followed by central retinal vein occlusion in 36 cases (31.57%), CRAO in 8 cases (7.01%), and hemi- retinal vein occlusion in 4 cases (3.50%). Hypertension was the most common, (40 cases, 35.08%) risk factor identified for retinal vascular occlusive disorders followed by diabetes 24 cases (21.05%), combined diabetes and hypertension in 22 cases (19.29%), and atherosclerosis in 18 cases (15.78%). Conclusions - Retinal vascular occlusive diseases have systemic as well as ocular risk factors. Understanding of these risk factors is essential for proper treatment of RVOD. Timely identification of risk factors for RVOD may helpful in decreasing ocular and systemic morbidity in these patients.

Methylenetetrahydrofolate reductase polymorphisms as risk factors for retinal venous occlusive disease: A literature review

2021 ◽  
pp. 112067212110006
Author(s):  
Manuel Marques ◽  
Francisco Alves ◽  
Miguel Leitão ◽  
Catarina Rodrigues ◽  
Joana Tavares Ferreira
Keyword(s):  
Risk Factors ◽  
Literature Review ◽  
Methylenetetrahydrofolate Reductase ◽  
Mthfr C677t ◽  
Mthfr Gene ◽  
Mthfr Polymorphisms ◽  
Vein Occlusion ◽  
C677t Mutation ◽  
Retinal Vascular Disease

The role of polymorphisms of methylenetetrahydrofolate reductase (MTHFR) gene in retinal vein occlusion (RVO) is a theme of discussion since the first reports of RVO in patients with MTHFR C677T mutation and without classic acquired risk factors for retinal vascular disease. The association between MTHFR polymorphisms and RVO has been studied over the last 20 years producing conflicting results. This review aims to summarize the literature concerning the role MTHFR polymorphisms as risk factors for RVO.

Sign in / Sign up

Export Citation Format

Share Document