The apple pectin influence on biochemical and hematological parameters in animals with chronic alcohol intoxication

2018 ◽  
Vol 22 (2) ◽  
pp. 280-284
Author(s):  
L.M. Sheremeta ◽  
M.B. Haynuk
Keyword(s):  
Silicon Dioxide ◽  
Activated Charcoal ◽  
Alcohol Intoxication ◽  
Hematological Parameters ◽  
Chronic Alcohol ◽  
Apple Pectin ◽  
Chronic Alcoholic ◽  
Treatment Protocols ◽  
Chronic Alcohol Intoxication ◽  
Partial Neutralization

Enterosorbents and prebiotics are included in treatment protocols for somatic disorders in chronic alcohol intoxication. Considering on relevant properties of pectin, the purpose of the study was to investigate its effect on biochemical and hematological parameters of experimental animals in chronic alcoholic intoxication. The study was conducted on 30 white outbred rats (males) weighing 180-200 g, which injected 30% ethanol into the stomach (control), animals in experimental groups after 30 minutes, got apple pectin at a dose of 0.2 g/100 g of body weight and reference preparations — activated charcoal and silicon dioxide — by 0.25 g and 0.05 g, respectively for 11 days. The statistical analysis was performed by Microsoft Exel and Statistica 5.5 (Multiple Regression) software using variation statistics methods. Research results. Changes in lipid metabolism were manifested by an increase in serum cholesterol of alcoholic animals without treatment by 29.8% compared with intact (p˂0.05). The use of pectin and reference drugs significantly reduced cholesterol levels. In the group with the use of pectin, this indicator was 36% lower, activated charcoal — by 19%, silicon dioxide — by 26.4% (p˂0,05) compared to untreated animals, at the same time, practically did not differ from intact animals. The level of triacylglycerols increased in all experimental groups and, although, it significantly differed from the intact, at the same time, it was essentially lower in all groups of treated animals than in non-treated ones (p˂0.05). A normalizing effect of pectin and silicon dioxide on the number of erythrocytes and hemoglobin levels comparing to alcoholated and treated activated charcoal animals also were shown (p˂0.05). The apple pectin curative effect on lipid and protein metabolism, as well as on the content of erythrocytes and hemoglobin in the blood of animals with chronic alcohol intoxication, practically equaled to standard enterosorbents, and on some indicators exceeds their effect, which may also be due to partial neutralization of ethanol.

scholarly journals Вплив яблучного пектину на окремі біохімічні та гематологічні показники алкоголізованих тварин

2018 ◽  
Author(s):  
L. M. Sheremeta ◽  
L. M. Haynuk
Keyword(s):  
Body Weight ◽  
Silicon Dioxide ◽  
Activated Charcoal ◽  
Blood Cells ◽  
Biochemical Parameters ◽  
Alcohol Intoxication ◽  
Hematological Parameters ◽  
Acute Alcohol Intoxication ◽  
Transaminase Activity ◽  
Apple Pectin

Introduction. the problem of acute and chronic alcohol intoxications is worldwide because of related injury and high mortality. Medical record protocols include absorbents among other medicines used in treatment of such poisonings.The aim of the study – to investigate the effect of apple pectin on hematological and some biochemical parameters of blood serum in acutely alcoholated rats and compare it with standard enterosorbents used in the clinic for acute alcohol poisoning.Recearch Methods. Experiments were conducted on 65 white outbred rats weighing 180–200 g, which were modeled acute alcohol intoxication by  introducing into the stomach 40 % solution of ethanol in a dose of 2 ml/100 g body weight. The influence of apple pectin (in dose 0.2 g/100 g of body  weight),and referenceagents (activated charcoal and silicon dioxide – 0.25 g and 0.05 g/100 g respectively) on biochemical and hematological parameters was estimated by changes in hemoglobin levels and the number of erythrocytes, glucose, cholesterol, and transaminase activity in serum.Results and Discussion. It was found that apple pectin when given in the stomach 30 min. before and an hour after the introduction of ethanol normalizes the level of red blood cells and hemoglobin (p˃0.05 compared to intact and other treated groups, but exceeded the level of those indicators by 18.5 % and 15.6 % in untreated animals respectively), improves the lipid (cholesterol) and hydrocarbon (glucose) metabolism and reduces the hepatocytecytolysis: the use of apple pectin in alcoholated rats lowered the activity of AsAT by 19.4 % and activity of AlAT by 16.6 % versus in treated with activated charcoal animals. At the same time mentioned effects were equated with those for the use of “white coal”.Conclusion. According to the determined indicators, the efficiency of pectin is equal to standard adsorbents used as reference products, and in some cases, predominates them.

Alcohol-induced damage to skeletal muscles in women with chronic alcohol intoxication

2021 ◽  
Vol 26 (4) ◽  
pp. 23-30
Author(s):  
N. S. Shcheglova ◽  
E. O. Zinovyeva ◽  
B. S. Shenkman
Keyword(s):  
Skeletal Muscle ◽  
Blood Plasma ◽  
Skeletal Muscles ◽  
Alcohol Intoxication ◽  
Femoral Nerve ◽  
Chronic Alcohol ◽  
Chronic Alcoholic ◽  
Chronic Alcohol Intoxication ◽  
Alcoholic Myopathy ◽  
In Blood Plasma

In Russia, there is a high level of alcohol consumption among women in doses that represent a high risk of developing alcoholic diseases, manifested, in particular, by damage to skeletal muscles.The purpose of the study. Analysis of clinical, biochemical, neurophysiological, as well as morphometric and immunohistochemical features of alcoholic skeletal muscle damage in women with chronic alcohol intoxication.Material and methods. A clinical and laboratory examination of 30 women aged 20 to 60 years with chronic alcohol intoxication was performed, which included the determination of creatine phosphokinase (CPK) and insulin-like growth factor I (IGF-I) in blood plasma, stimulation and needle electromyography (EMG), as well as morphological and immunohistochemical examination of biopsies of the quadriceps femoris.Results. Myopathic syndrome in the form of proximal para-or tetraparesis was observed in 73.3% of the examined women in combination with a decrease in IGF-1 at normal values of CPK in blood plasma. The EMG results indicated the absence of changes in the parameters of the potentials of motor units, characteristic of primary muscular lesions, and of conduction disturbances along the femoral nerve. Morphometric and immunohistochemical studies of skeletal muscle biopsies showed a decrease in the cross-sectional area of muscle fibers of types I and II without signs of muscle tissue necrosis.Conclusion. Chronic alcoholic myopathy is a common manifestation of alcoholic disease in women with long-term alcohol intoxication. The severity of the atrophic process in the skeletal muscle is comparable to the degree of proximal paresis. Violations of systemic protein synthesis and acceleration of apoptosis are considered as pathogenetic mechanisms of the atrophic process in the muscles in chronic alcoholic myopathy in women.

scholarly journals Age features of liver functional state in experimental chronic al coholic liver damage and correction by quercetin and L-arginine L-glutamate

2015 ◽  
Vol 17 (4) ◽  
Author(s):  
N. A. Rykalo ◽  
L. O. Yarovenko
Keyword(s):  
Functional State ◽  
Liver Damage ◽  
Alcohol Intoxication ◽  
Chronic Alcohol ◽  
Chronic Alcoholic ◽  
Laboratory Rats ◽  
Chronic Alcohol Intoxication ◽  
Synthetic Function ◽  
Old Rats ◽  
Age Features

<p>The article is about the research and study of the influence of the chronic alcohol intoxication on serum biochemical<br />data at the immature, mature аnd old rats and results with chronic alcoholic liver damage and correction<br />of by quercetin and L-arginine L-glutamate. Chronic alcoholic liver damage is accompanied by the deviations of the<br />main reliable biochemical data of carbohydrate, protein and lipid metabolism at the laboratory rats of the both age<br />groups. The presence of cytolysis syndrome, cholestasis, mesenchymal inflammation confirm the development of<br />hepatocellular insufficiency. It was established that quercetin restores protein synthetic function of the liver, and<br />L-arginine L-glutamate significantly improved the functional state of the liver, which was manifested by decreasing<br />of the intensity of cytolytic, cholestatic processes and of the manifestations of toxic liver damage and restoring the<br />reparative regeneration of liver tissue at the immature, mature and old rats with chronic alcohol intoxication.</p>

Features of the sensitivity of the central nervous system of the organism of experimental animals to the effects of certain psychotropic drugs and their combinations against the background of chronic alcohol intoxication in a chronopharmacological experiment

2020 ◽  
pp. 56-62
Author(s):  
E.V. Filippova
Keyword(s):  
Alcohol Intoxication ◽  
Laboratory Animals ◽  
Histological Structure ◽  
Chronic Alcohol ◽  
Behavioral Reactions ◽  
Experimental Animals ◽  
Chronic Alcohol Intoxication ◽  
Psychotropic Action ◽  
Adaptive Effect ◽  
The Central Nervous System

In a chronopharmacological experiment, the effect of two drugs with psychotropic action in combinations on the behavior of laboratory animals subjected to chronic alcohol intoxication was examined. Against the background of a deprimating agent, a decrease in the threshold of sensitivity to electrical irritation and the duration of an aggressive reaction was revealed; an increase in these indicators was established with a combination of a deprimating drug with an antioxidant. It has been shown that the antioxidant has a desynchronizing effect on the behavioral reactions of laboratory animals for two days, which indicates a pronounced adaptive effect. In the case of using combinations of a deprimating agent with an antioxidant, a decrease in the destruction of the histological structure of the myocardium against the background of chronic alcoholization was established.

scholarly journals The effect of chronic alcohol intoxication and smoking on the output of salivary immunoglobulin A

2012 ◽  
Vol 50 (4) ◽  
pp. 605-608 ◽  
Author(s):  
Napoleon Waszkiewicz ◽  
Anna Zalewska ◽  
Slawomir Dariusz Szajda ◽  
Magdalena Waszkiewicz ◽  
Agata Szulc ◽  
...  
Keyword(s):  
Alcohol Intoxication ◽  
Immunoglobulin A ◽  
Chronic Alcohol ◽  
Chronic Alcohol Intoxication ◽  
Salivary Immunoglobulin A

scholarly journals Nervous system injury in alcoholic disease

2019 ◽  
Vol 11 (2S) ◽  
pp. 83-88
Author(s):  
O. E. Zinovyeva ◽  
N. V. Vashchenko ◽  
O. E. Mozgovaya ◽  
T. A. Yanakaeva ◽  
A. Yu. Emelyanova
Keyword(s):  
Nervous System ◽  
Peripheral Nervous System ◽  
Alcohol Intoxication ◽  
Clinical Manifestations ◽  
Symptomatic Treatment ◽  
Chronic Alcohol ◽  
Neurological Manifestations ◽  
Chronic Alcohol Intoxication ◽  
Alcoholic Disease

The paper considers various variants of nervous system injury in alcoholic disease. It discusses the epidemiology, pathogenesis, diagnosis, and clinical manifestations of central and peripheral nervous system lesions in the presence of acute and chronic alcohol intoxication. Attention is paid to the issues of etiotropic, pathogenetic, and symptomatic treatment for neurological manifestations of alcoholic disease and to the role of neurotropic B vitamins in the treatment of alcohol-induced deficiency and non-deficiency states.

scholarly journals Development of a prediabetic state under chronic alcohol intoxication

2013 ◽  
Vol 59 (4) ◽  
pp. 33-39 ◽  
Author(s):  
VV Voĭtenko ◽  
◽  
VV Konopel'niuk ◽  
OM Savchuk ◽  
LI Ostapchenko ◽  
...  
Keyword(s):  
Alcohol Intoxication ◽  
Chronic Alcohol ◽  
Prediabetic State ◽  
Chronic Alcohol Intoxication

scholarly journals The effect of chronic alcohol intoxication and smoking on the activity of oral peroxidase

2012 ◽  
Vol 50 (3) ◽  
pp. 450-455 ◽  
Author(s):  
Napoleon Waszkiewicz ◽  
Anna Zalewska ◽  
Sławomir Dariusz Szajda ◽  
Agata Szulc ◽  
Alina Kępka ◽  
...  
Keyword(s):  
Alcohol Intoxication ◽  
Chronic Alcohol ◽  
Chronic Alcohol Intoxication
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