Incidence of chronic Hepatitis B among Orang Asli in Pahang

Introduction: The rate of Hepatitis B infection in Malaysia is 4.7% and the prevalence of Hepatitis B infection varies among ethnic group in Malaysia. The estimated prevalence of chronic Hepatitis B among Orang Asli in Malaysia is 8.3%. Methods: 232 Orang Asli participated in this study on a voluntary basis during two health screening in two Orang Asli Villages. Subjects serum HBsAg and HBsAb titres were taken and analyzed. Results: From 232 participants, there are 24 subjects who are HBsAg positive (10.3%) and only 15.9% of the population study has immunity to Hepatitis B. Conclusions: The incidence of chronic Hepatitis B among Orang Asli in Pahang is higher than the general population, and the rate of immunity to Hepatitis B are low compared to the general population.

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A large population study of spontaneous HBeAg seroconversion and acute exacerbation of chronic hepatitis B infection: implications for antiviral therapy

Gut ◽

10.1136/gut.52.3.416 ◽

2003 ◽

Vol 52 (3) ◽

pp. 416-419 ◽

Cited By ~ 81

Author(s):

M-F Yuen

Keyword(s):

Chronic Hepatitis ◽

Hepatitis B ◽

Antiviral Therapy ◽

Acute Exacerbation ◽

Chronic Hepatitis B ◽

Population Study ◽

Hbeag Seroconversion ◽

Large Population ◽

Hepatitis B Infection ◽

Chronic Hepatitis B Infection

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Current prevalence of chronic hepatitis B and C virus infection in the general population and other low-risk populations of the EU/EEA: a systematic review

10.26226/morressier.57fe118cd462b8028d890793 ◽

2016 ◽

Author(s):

Sanne Hofstraat

Keyword(s):

Systematic Review ◽

Chronic Hepatitis ◽

General Population ◽

Virus Infection ◽

Hepatitis B ◽

Chronic Hepatitis B ◽

Low Risk ◽

Current Prevalence ◽

The Eu

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Update in management of hepatitis B in pregnancy and prevention of mother to child hepatitis B transmission

Thai Journal of Hepatology ◽

10.30856/th.jhep2018vol1iss3_01 ◽

2018 ◽

Vol 1 (3) ◽

pp. 1-8

Author(s):

Naichaya Chamroonkul

Keyword(s):

Chronic Hepatitis ◽

Viral Load ◽

Hepatitis B ◽

Chronic Hepatitis B ◽

High Viral Load ◽

World Population ◽

Hepatitis B Infection ◽

Mother To Child Transmission ◽

Child Transmission ◽

Mother To Child

Even with two decades of widespread using hepatitis B vaccination, chronic hepatitis B remains a major global health problem. In Thailand, the prevalence of chronic hepatitis B infection was down from 8 - 10% in last decade to 5% recently. Failure to control mother to child transmission is one of the important barriers to the total elimination of hepatitis B infection from world population. In the majority, vertical transmission can be prevented with a universal screening program, immunoprophylaxis by administration of hepatitis B vaccine and hepatitis B immunoglobulin (HBIg) for babies born to mothers with HBV. However, in mothers with a high viral load, the chance of immunoprophylaxis failure remains high. To date, there are standard recommendations by all international liver societies including AASLD, EASL and APASL suggest introducing an antiviral agent during the third trimester to CHB pregnant women with a high viral load. Previous US FDA pregnancy category B agents such as Tenofovir and Telbivudine are allowed through all trimesters of pregnancy and are effective for prevention of mother to child transmission. Breastfeeding for patients who receive antiviral agents can be allowed after a risk-benefit discussion with the patient and family.

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