The Effect of Physical Activity on Cognition Relative to APOE Genotype

Abstract Background Physical activity may decrease the risk of dementia; however, previous cohort studies seldom investigated the different types of physical activity and household activities. Our objective was to analyze the links between two physical activity types and dementia in older people. Methods The study used data from the prospective observational Three-city cohort and included 1550 community-dwelling individuals aged 72 to 87 without dementia at baseline. Physical activity was assessed with the Voorrips questionnaire. Two sub-scores were calculated to assess household/transportation activities and leisure/sport activities. Restricted cubic spline and proportional hazard Cox models were used to estimate the non-linear exposure-response curve for the dementia risk and the appropriate activity level thresholds. Models were adjusted for possible confounders, including socio-demographic variables, comorbidities, depressive symptoms and APOE genotype. Results The median age was 80 years, and 63.6% of participants were women. After a median follow-up of 4.6 years, dementia was diagnosed in 117 participants (7.6%). An inverse J-shaped association was found between household/transportation physical activity sub-score and dementia risk, which means that the risk is lowest for the moderately high values and then re-increases slightly for the highest values. The results remained significant when this sub-score was categorized in three classes (low, moderate, and high), with hazard ratios (95% confidence interval) of 0.55 (0.35-0.87) and 0.62 (0.38-1.01) for moderate and high activity levels, respectively. No significant effect was found for leisure/sport activities. Conclusions The 5-year risk of dementia was significantly and negatively associated with the household/transportation activity level, but not with the leisure and sport activity sub-score. This highlights the importance of considering all physical activity types in 72 years or older people.

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A systematic review on the potential role of APOE genotype as a moderator in the relationship between physical activity, brain health and dementia risk

Alzheimer s & Dementia ◽

10.1002/alz.045559 ◽

2020 ◽

Vol 16 (S10) ◽

Author(s):

Jaisalmer de Frutos ◽

Juan Manuel Serrano Rodriguez ◽

Fernando Maestú ◽

Simon M Laws ◽

Belinda M Brown

Keyword(s):

Physical Activity ◽

Systematic Review ◽

Potential Role ◽

Apoe Genotype ◽

Brain Health ◽

Dementia Risk ◽

The Relationship

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Physical activity modulates the effect of APOE genotype on HDL-cholesterol concentrations in a spanish population

Atherosclerosis Supplements ◽

10.1016/s1567-5688(02)80228-8 ◽

2002 ◽

Vol 3 (2) ◽

pp. 115

Keyword(s):

Physical Activity ◽

Apoe Genotype ◽

Hdl Cholesterol ◽

Spanish Population

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Age and APOE genotype affect the relationship between objectively measured physical activity and power in the alpha band, a marker of brain disease.

10.21203/rs.3.rs-27040/v1 ◽

2020 ◽

Author(s):

Jaisalmer de Frutos-Lucas ◽

Pablo Cuesta ◽

Federico Ramirez-Toraño ◽

Alberto Nebreda ◽

Esther Cuadrado-Soto ◽

...

Keyword(s):

Physical Activity ◽

Older Adults ◽

Protective Factor ◽

Brain Activity ◽

Apoe Genotype ◽

Alpha Power ◽

Alpha Band ◽

Electrophysiological Studies ◽

The Relationship ◽

Predicted Risk

Abstract BACKGROUND Electrophysiological studies show that reductions in power within the alpha band are associated with the Alzheimer’s disease (AD) continuum. Physical activity (PA) is a protective factor that has proved to reduce AD risk and pathological brain burden. Previous research has confirmed that exercise increases power in the alpha range. However, little is known regarding whether other non-modifiable risk factors for AD, such as increased age or APOE ε4 carriage, alter the association between PA and power in the alpha band.METHODS The relationship between PA and alpha power band was examined in a sample of 113 healthy adults using magnetoencephalography. Additionally, we explored whether ε4 carriage and age modulate this association. The correlations between alpha power and gray matter volumes and cognition were also investigated.RESULTS We detected a parieto-occipital cluster in which PA positively correlated with alpha power. The association between PA and alpha power remained following stratification of the cohort by genotype. Younger and older adults were investigated separately, and younger adults only exhibited a positive relationship between PA and alpha power. Interestingly, when four groups were created based on age (younger-older adult) and APOE (E3/E3-E3/E4), only younger E3/E3 (least predicted risk) and older E3/E4 (greatest predicted risk) had associations between greater alpha power and higher PA. Among older E3/E4, greater alpha power in these regions was associated with improved memory and preserved brain structure.CONCLUSION PA could protect against the slowing of brain activity that characterizes the AD continuum, where it is of benefit for all individuals, especially E3/E4 older adults.

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Using Individual, ApoE Genotype-Based Dietary and Physical Activity Advice to Promote a Healthy Lifestyle: Associations between Psychological, Behavioral and Clinical Factors

Journal of Nutritional Health & Food Science ◽

10.15226/jnhfs.2015.00152 ◽

2015 ◽

Vol 3 (4) ◽

pp. 01-07

Author(s):

Hanna-Leena Hietaranta-Luoma

Keyword(s):

Physical Activity ◽

Healthy Lifestyle ◽

Apoe Genotype ◽

Clinical Factors ◽

Physical Activity Advice

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Association of Physical Activity and APOE Genotype With Longitudinal Cognitive Change in Early PD

Neurology ◽

10.1212/wnl.0000000000011852 ◽

2021 ◽

pp. 10.1212/WNL.0000000000011852

Author(s):

Ryul Kim ◽

Sangmin Park ◽

Dallah Yoo ◽

Jin-Sun Jun ◽

Beomseok Jeon

Keyword(s):

Physical Activity ◽

Cognitive Decline ◽

Significant Interaction ◽

Apoe Genotype ◽

The Elderly ◽

Cognitive Change ◽

Cognitive Changes ◽

Progression Markers ◽

Ε4 Allele

Objective:To determine whether greater physical activity could modify the negative association of APOE ε4 with longitudinal cognitive changes in early Parkinson’s disease (PD) and to uncover the disease-specific mechanism for explaining such benefits of physical activity.Methods:We used data from the Parkinson’s Progression Markers Initiative cohort. Because self-reported physical activity, measured by the Physical Activity Scale of the Elderly, was initiated at 2 years after enrollment, this longitudinal analysis was based on assessments performed at years 2, 3, and 4. Cognitive function was measured annually with the Montreal Cognitive Assessment (MoCA). Dopamine transporter (DAT) imaging was performed at years 2 and 4. We assessed the interactive associations between physical activity and the APOE ε4 allele on the longitudinal changes in MoCA scores and striatal DAT activities.Results:A total of 173 early PD patients (age 63.3±10.0 years; 27% APOE ε4 carriers) were included. The APOE ε4 allele showed a steeper rate of cognitive decline than the non-APOE ε4 allele (estimate -1.33; 95% CI, -2.12 to -0.47; p=0.002). However, there was a significant interaction between physical activity and APOE ε4, such that higher physical activity was related to slower APOE ε4-related cognitive decline (estimate 0.007; 95% CI, 0.003 to 0.011; p=0.001). No significant interaction was found between physical activity and the APOE ε4 allele regarding the change in striatal DAT activities.Conclusion:Increased physical activity attenuated APOE ε4-related vulnerability to early cognitive decline in PD patients. This protective effect did not appear to be mediated by striatal dopaminergic function.Classification of evidence:This study provides Class II evidence that increased physical activity was associated with decreased APOE ε4-related early cognitive decline in PD patients.

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O2-02-05: APOE GENOTYPE-DEPENDENT EFFECTS OF DIET AND PHYSICAL ACTIVITY ON COGNITION AND ALZHEIMER'S-RELATED PATHOLOGY: DATA FROM THE AIPL STUDY OF AGEING

Alzheimer s & Dementia ◽

10.1016/j.jalz.2014.04.165 ◽

2014 ◽

Vol 10 ◽

pp. P166-P166

Author(s):

Stephanie R. Rainey-Smith ◽

Belinda Brown ◽

Samantha Gardener ◽

Jeremiah Peiffer ◽

Pierrick Bourgeat ◽

...

Keyword(s):

Physical Activity ◽

Apoe Genotype ◽

Diet And Physical Activity ◽

Pathology Data

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Using Individual, ApoE Genotype-Based Dietary and Physical Activity Advice to Promote Healthy Lifestyles in Finland—Impacts on Cardiovascular Risk Markers

Open Journal of Preventive Medicine ◽

10.4236/ojpm.2015.55024 ◽

2015 ◽

Vol 05 (05) ◽

pp. 206-217 ◽

Cited By ~ 3

Author(s):

Hanna-Leena Hietaranta-Luoma ◽

Kari Åkerman ◽

Raija Tahvonen ◽

Hannu Puolijoki ◽

Anu Hopia

Keyword(s):

Physical Activity ◽

Cardiovascular Risk ◽

Apoe Genotype ◽

Healthy Lifestyles ◽

Risk Markers ◽

Physical Activity Advice

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Age and APOE genotype affect the relationship between objectively measured physical activity and power in the alpha band, a marker of brain disease.

10.21203/rs.3.rs-27040/v2 ◽

2020 ◽

Author(s):

Jaisalmer de Frutos-Lucas ◽

Pablo Cuesta ◽

Federico Ramirez-Toraño ◽

Alberto Nebreda ◽

Esther Cuadrado-Soto ◽

...

Keyword(s):

Physical Activity ◽

Older Adults ◽

Protective Factor ◽

Brain Activity ◽

Apoe Genotype ◽

Alpha Power ◽

Alpha Band ◽

Electrophysiological Studies ◽

The Relationship ◽

Predicted Risk

Abstract BACKGROUND: Electrophysiological studies show that reductions in power within the alpha band are associated with the Alzheimer’s disease (AD) continuum. Physical activity (PA) is a protective factor that has proved to reduce AD risk and pathological brain burden. Previous research has confirmed that exercise increases power in the alpha range. However, little is known regarding whether other non-modifiable risk factors for AD, such as increased age or APOE ε4 carriage, alter the association between PA and power in the alpha band. METHODS: The relationship between PA and alpha band power was examined in a sample of 113 healthy adults using magnetoencephalography. Additionally, we explored whether ε4 carriage and age modulate this association. The correlations between alpha power and gray matter volumes and cognition were also investigated. RESULTS: We detected a parieto-occipital cluster in which PA positively correlated with alpha power. The association between PA and alpha power remained following stratification of the cohort by genotype. Younger and older adults were investigated separately, and only younger adults exhibited a positive relationship between PA and alpha power. Interestingly, when four groups were created based on age (younger-older adult) and APOE (E3/E3-E3/E4), only younger E3/E3 (least predicted risk) and older E3/E4 (greatest predicted risk) had associations between greater alpha power and higher PA. Among older E3/E4, greater alpha power in these regions was associated with improved memory and preserved brain structure. CONCLUSION: PA could protect against the slowing of brain activity that characterizes the AD continuum, where it is of benefit for all individuals, especially E3/E4 older adults.

Download Full-text