Integrated Approaches for Identifying Molecular Targets in Liver Disease

2019 ◽  
Author(s):  
Keyword(s):  
Liver Disease ◽  
Molecular Targets ◽  
Integrated Approaches

A round trip from nonalcoholic fatty liver disease to diabetes: molecular targets to the rescue?

2018 ◽  
Vol 56 (4) ◽  
pp. 385-396 ◽  
Author(s):  
Amedeo Lonardo ◽  
Simonetta Lugari ◽  
Stefano Ballestri ◽  
Fabio Nascimbeni ◽  
Enrica Baldelli ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Molecular Targets ◽  
Round Trip ◽  
Nonalcoholic Fatty Liver

Molecular Targets in Liver Disease

2020 ◽  
pp. 587-598
Author(s):  
Andrea Ferrigno ◽  
Laura Giuseppina Di Pasqua ◽  
Mariapia Vairetti
Keyword(s):  
Liver Disease ◽  
Molecular Targets

scholarly journals Pathogenesis of and major animal models used for nonalcoholic fatty liver disease

2019 ◽  
Vol 47 (4) ◽  
pp. 1453-1466 ◽  
Author(s):  
Mingzuo Jiang ◽  
Nan Wu ◽  
Xi Chen ◽  
Weijie Wang ◽  
Yi Chu ◽  
...  
Keyword(s):  
Liver Disease ◽  
Animal Models ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Metabolic Diseases ◽  
Molecular Targets ◽  
Severe Form ◽  
Nonalcoholic Fatty Liver ◽  
Increased Risk

Nonalcoholic fatty liver disease (NAFLD) and its pathologically more severe form, nonalcoholic steatohepatitis (NASH), have become prevalent worldwide and carry an increased risk of developing hepatocellular carcinoma and other metabolic diseases. Diverse animal models have been proposed to replicate particular characteristics of NAFLD and NASH and have provided significant clues to the critical molecular targets of NASH treatment. In this review, we summarize the histopathology, pathogenesis, and molecular basis of NAFLD progression and discuss the benchmark animal models of NAFLD/NASH.

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