The Effect of Melatonin on Postoperative Pain Reduction After Orthognathic Surgery

2019 ◽  
Author(s):  
Keyword(s):  
Postoperative Pain ◽  
Orthognathic Surgery ◽  
Pain Reduction

Postoperative Pain Reduction in Thoracic Surgery through Multifactorial Treatment Approach

2016 ◽  
Vol 64 (S 01) ◽  
Author(s):  
F. Dörr ◽  
S. Macherey ◽  
M. Heldwein ◽  
S. Stange ◽  
T. Wahlers ◽  
...  
Keyword(s):  
Postoperative Pain ◽  
Thoracic Surgery ◽  
Treatment Approach ◽  
Pain Reduction

Effect of Preoperative Rectal Indomethacin on Postoperative Pain Reduction After Open Cholecystectomy

2010 ◽  
Vol 25 (1) ◽  
pp. 7-10 ◽  
Author(s):  
Mostafa Mehrabi Bahar ◽  
Ali Jangjoo ◽  
Ehsan Soltani ◽  
Masoomeh Armand ◽  
Samira Mozaffari
Keyword(s):  
Postoperative Pain ◽  
Open Cholecystectomy ◽  
Pain Reduction ◽  
Rectal Indomethacin

Postoperative Pain and Opioid Analgesic Requirements After Orthognathic Surgery

2018 ◽  
Vol 76 (11) ◽  
pp. 2285-2295 ◽  
Author(s):  
Ashkan Mobini ◽  
Pushkar Mehra ◽  
Radhika Chigurupati
Keyword(s):  
Postoperative Pain ◽  
Orthognathic Surgery ◽  
Opioid Analgesic

scholarly journals 4326 Effects of Single-dose Preoperative Pregabalin on Postoperative Pain and Opioid Consumption in Cleft Orthognathic Surgery

2020 ◽  
Vol 4 (s1) ◽  
pp. 29-29
Author(s):  
Abdullah Said ◽  
Ema Zubovic ◽  
Austin Y Ha ◽  
Gary B Skolnic ◽  
Jacob AuBuchon ◽  
...  
Keyword(s):  
Single Dose ◽  
Postoperative Pain ◽  
Orthognathic Surgery ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Opioid Consumption ◽  
Control Group ◽  
Assessment Scores ◽  
Pain Scores ◽  
Post Operative Pain

OBJECTIVES/GOALS: The current opioid epidemic has placed post-operative pain management under scrutiny. Limiting post-operative pain can decrease overall opioid usage in the recovery period, especially after orthognathic surgery. Several studies have illustrated the efficacy of pregabalin in decreasing postoperative pain and opioid usage in adults undergoing orthognathic surgery. We aim to study the effects of a single dose of preoperative pregabalin on postoperative pain and total opioid consumption after orthognathic surgery in individuals with cleft lip and palate. METHODS/STUDY POPULATION: This was a retrospective cohort study of consecutive patients who received Le Fort I midface advancement between June 2012 and July 2019 by one of two surgeons at a single institution. We took advantage of our institution’s implementation, beginning in 2016, of a one-time dose of preoperative pregabalin for LeFort I midface advancement. All patients had diagnosed cleft lip and palate. The treatment group received a one-time preoperative dose of pregabalin. The control group did not receive pregabalin. Total morphine milligram equivalents (MME) consumption was calculated by adding intraoperative opioid administration and postoperative opioid consumption during admission. Postoperative pain control during admission consisted of oral oxycodone and intravenous (IV) hydromorphone or morphine. Duration of hospitalization and pain intensity assessed with the numeric pain rating scale (0-10) were also recorded. The mean postoperative pain assessment scores during admission was calculated for each patient. The median of these individual mean pain assessment scores for each group was subsequently computed. RESULTS/ANTICIPATED RESULTS: Twenty-three patients (14 males, 9 females) were included in this study; 12 patients received pregabalin (median dose: 150mg, range: 100-200mg). Mean age (years) at operation of the pregabalin (18.3 ± 1.9) and control groups (17.8 ± 1.9) were also equivalent (p = 0.571). Median hospital stay for both groups was 1.0 day. The pregabalin group had significantly lower consumption of total opioids during admission (total MME 70.95 MME; IQR: 24.65-150.17) compared to the control group (138.00 MME; IQR: 105.00-232.48) (MU = 31.00, p = 0.031). Although pain scores in the treatment group (3.21 ± 2.03) were lower than in the control group (3.71 ± 2.95), the difference was not statistically significant (p = 0.651, 95% Cl [−1.75, 2.75]). DISCUSSION/SIGNIFICANCE OF IMPACT: Based on the results, a one-time preoperative oral dose of pregabalin before orthognathic surgery in patients with cleft lip and palate reduced total opioid consumption during admission. However, there was no difference in length of stay or pain scores within the two groups. A single preemptive oral dose of pregabalin should be considered an effective adjunct to pain management protocols in patients undergoing orthognathic surgery.

scholarly journals The impact of medical clowns exposure over postoperative pain and anxiety in children and caregivers: An Israeli experience

2019 ◽  
Vol 11 (3) ◽  
Author(s):  
Nitza Newman ◽  
Slava Kogan ◽  
Moshe Stavsky ◽  
Shay Pintov ◽  
Yotam Lior
Keyword(s):  
Pain Management ◽  
Postoperative Pain ◽  
Therapy Group ◽  
Postoperative Pain Management ◽  
Serum Cortisol ◽  
Pain Reduction ◽  
Parental Distress ◽  
Post Surgery ◽  
Emotional Outcomes ◽  
The Impact

While postoperative pain management was shown to reduce unwanted physiological and emotional outcomes, pediatric postoperative pain management remains suboptimal. Medical-clowns were shown to be beneficial in many medical contexts including reduction of stress, anxiety and pain. This study was set to assess the effectiveness of medical-clowns on pediatric postoperative pain reduction. Children age 4 or above, planned for elective hernia repair surgery were recruited. Children were randomly divided to a control or medicalclown escorted groups. Demographical and clinical data were collected using questionnaires and electronic sheets. Children escorted by clowns reported lower levels of pain upon admittance, discharge and 12-hours post-surgery. Statistically significant reduction of parental distress and significantly higher serum cortisol levels were observed in the clown-therapy group. Although small, our study supports the possibility that preoperative medical-clown therapy might be a cheap, safe and yet beneficial method for postoperative pain reduction.

Intraoperative Esmolol as an Adjunct for Perioperative Opioid and Postoperative Pain Reduction

2018 ◽  
Vol 126 (3) ◽  
pp. 1035-1049 ◽  
Author(s):  
Amanda M. Gelineau ◽  
Michael R. King ◽  
Karim S. Ladha ◽  
Sara M. Burns ◽  
Timothy Houle ◽  
...  
Keyword(s):  
Postoperative Pain ◽  
Pain Reduction

scholarly journals Efficacy of Preemptive Analgesia with Pregabalin in Orthognathic Surgery-A Systematic Review

2021 ◽  
pp. 334-340
Author(s):  
Subhashini Ramasubbu ◽  
Abdul Wahab
Keyword(s):  
Systematic Review ◽  
Postoperative Pain ◽  
Central Sensitization ◽  
Orthognathic Surgery ◽  
Pain Treatment ◽  
Oral Surgery ◽  
Preemptive Analgesia ◽  
Surgical Trauma ◽  
Acute Postoperative Pain ◽  
Manual Search

Background: Orthognathic surgery is a treatment approach that is used for correcting the congenital or developmental anomalies of maxilla and mandible as well as secondary deformities of trauma. During these procedure saws, chisels, separators, and plate screw systems are used. Postoperative pain is an acute pain that is accompanied by the inflammatory process that occurs as a result of surgical trauma, and gradually decreases with tissue recovery. The analgesic prevents the establishment of the central sensitization due to incisional injury (only covers the surgical period) and prevents the establishment of the central sensitization (covering the surgical and early postoperative periods). Pregabalin is a structural gama-aminobutyric acid (GABA) analogue. It has been shown in recent studies that pregabalin, which is involved in chronical pain treatment, can also be involved in acute postoperative pain treatment. Objectives: The aim of this systematic review is to assess the efficacy of preemptive analgesia with pregabalin on postoperative pain in orthognathic surgery. Materials and Methods: The Data Bases of PubMed, Cochrane and Google scholar were searched for the related topics along with a complimentary manual search of all oral surgery journals till September 2019. Articles were selected based on the inclusion criteria, which included all RCTs. Results: From this systematic review it is concluded that pre-emptive analgesia with pregabalin is effective in lowering acute postoperative pain in the patients who have undergone orthognathic surgery. Conclusion: In this systematic review we have concluded that, on average, a single dose of pregabalin was shown to decrease post-operative pain. More studies have to be done to evaluate the efficacy of the drug.   

scholarly journals Antidepressant Drugs for Prevention of Acute and Chronic Postsurgical Pain

2014 ◽  
Vol 121 (3) ◽  
pp. 591-608 ◽  
Author(s):  
Karen Wong ◽  
Rachel Phelan ◽  
Eija Kalso ◽  
Imelda Galvin ◽  
David Goldstein ◽  
...  
Keyword(s):  
Postoperative Pain ◽  
Therapeutic Potential ◽  
Antidepressant Treatment ◽  
Antidepressant Drugs ◽  
Safety Evaluation ◽  
Pain Reduction ◽  
Chronic Postoperative Pain ◽  
Postsurgical Pain ◽  
Chronic Postsurgical Pain ◽  
Antidepressant Use

Abstract Background: This review evaluates trials of antidepressants for acute and chronic postsurgical pain. Methods: Trials were systematically identified using predefined inclusion and exclusion criteria. Extracted data included the following: pain at rest and with movement, adverse effects, and other outcomes. Results: Fifteen studies (985 participants) of early postoperative pain evaluated amitriptyline (three trials), bicifadine (two trials), desipramine (three trials), duloxetine (one trial), fluoxetine (one trial), fluradoline (one trial), tryptophan (four trials), and venlafaxine (one trial). Three studies (565 participants) of chronic postoperative pain prevention evaluated duloxetine (one trial), escitalopram (one trial), and venlafaxine (one trial). Heterogeneity because of differences in drug, dosing regimen, outcomes, and/or surgical procedure precluded any meta-analyses. Superiority to placebo was reported in 8 of 15 trials for early pain reduction and 1 of 3 trials for chronic pain reduction. The majority of positive trials did not report sufficient data to estimate treatment effect sizes. Many studies had inadequate size, safety evaluation/reporting, procedure specificity, and movement-evoked pain assessment. Conclusions: There is currently insufficient evidence to support the clinical use of antidepressants—beyond controlled investigations—for treatment of acute, or prevention of chronic, postoperative pain. Multiple positive trials suggest the therapeutic potential of antidepressants, which need to be replicated. Other nontrial evidence suggests potential safety concerns of perioperative antidepressant use. Future studies are needed to better define the risk–benefit ratio of antidepressants in postoperative pain management. Higher-quality trials should optimize dosing, timing and duration of antidepressant treatment, trial size, patient selection, safety evaluation and reporting, procedure specificity, and assessment of movement-evoked pain relevant to postoperative functional recovery.

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