scholarly journals Development of the voltammetric method for the quantitative determination of bendazole hydrochloride

2021 ◽  
pp. 55-64
Author(s):  
E.Yu. Zherebtsova ◽  
◽  
S.V. Terentyeva ◽  
E.A. Ivanovskaya ◽  
T.G. Shinko ◽  
...  
Keyword(s):  
Ph Value ◽  
Biological Fluids ◽  
Sweep Rate ◽  
Potential Sweep Rate ◽  
Pharmacokinetic Parameters ◽  
Wide Field ◽  
The Novel ◽  
Potential Sweep ◽  
Voltammetric Method

In connection with the wide field of application of bendazole hydrochloride in medicine and its use as a part of combined drugs, an assessment of the effectiveness of the novel dosage forms and the determination of pharmacokinetic parameters are required. For this purpose, it is necessary to obtain data on the concentration of the studied drug in biological fluids. The aim of this research is to develop a voltammetric method for the bendazole hydrochloride quantification. In the course of the study, the optimal electrolysis conditions were established: potential was –1.8 V, time 15 s, and potential sweep rate 50 mV/s. The opti-mum pH value for electrolysis of bendazole hydrochloride is 6–7. The proposed method is validated by tests: specificity and linearity, detection limit; the range of the procedure and its analytical precision were determined. Thus, the developed method can be used for the quantification of bendazole hydrochloride in pharmaceutical substances.

Growth of Ultra-thin Titanium Dioxide Films by Complete Anodic Oxidation of Titanium Layers on Conductive Substrates

2012 ◽  
Vol 1494 ◽  
pp. 159-164
Author(s):  
Karsten Wolff ◽  
Petri Heljo ◽  
Donald Lupo
Keyword(s):  
Titanium Dioxide ◽  
Anodic Oxidation ◽  
Defect Density ◽  
Ph Value ◽  
Sweep Rate ◽  
Potential Sweep Rate ◽  
Minor Role ◽  
Potential Sweep ◽  
Titanium Dioxide Films ◽  
Conductive Substrates

ABSTRACTThe growth of thin and ultra-thin titanium dioxide layers was investigated. Oxide films were grown by galvanostatic and potentiodynamic anodisation of evaporated titanium layers on conductive substrates. It is shown that thin-film oxidation differs significantly from anodic oxidation of solid foils or plates, due to the sudden stop of anodisation process before complete oxidation of the thick films. Depending on the pH value and the potential sweep rate, the effective defect density and the dielectric constant of the anodized layers vary from 3·1019 cm-3 to 1020 cm-3and from 16 to 27, respectively, whereas the electrolyte temperature plays only a minor role.

scholarly journals EFFECT OF CALCIUM ON THE ANODIC BEHAVIOR OF ALUMINUM CONDUCTOR ALLOY AlTi0.1 IN THE MEDIUM OF THE ELECTROLYTE NaCl

2021 ◽  
Vol 58 ◽  
pp. 33-37
Author(s):  
Izatullo N. Ganiev ◽  
◽  
Rustam J. Fayzulloev ◽  
Furkatshokh Sh. Zokirov ◽  
◽  
...  
Keyword(s):  
Experimental Study ◽  
Aluminum Alloy ◽  
Corrosion Rate ◽  
Sweep Rate ◽  
Potential Sweep Rate ◽  
Anodic Behavior ◽  
Potential Sweep ◽  
Potentiostatic Method ◽  
Corrosion Pitting ◽  
Range Of Values

The article presents the results of an experimental study of the effect of calcium on the anodic behavior of the aluminum alloy AlTi0.1, in the medium of NaCl electrolyte. The study was carried out by the potentiostatic method in the potentiodynamic mode at the potential sweep rate of 2 mV / s. It is shown that the modification of the aluminum alloy AlTi0.1 with calcium promotes the displacement of the potentials of free corrosion, pitting formation, and repassivation to the positive range of values. The corrosion rate of the aluminum alloy AlTi0.1 when modified with 0.01-0.5 wt % calcium decreases by 10-17 %.

scholarly journals Pharmacometabonomics – the novel way to personalized drug therapy

2017 ◽  
Vol 63 (2) ◽  
pp. 115-123 ◽  
Author(s):  
D.L. Maslov ◽  
E.E. Balashova ◽  
P.G. Lokhov ◽  
A.I. Archakov
Keyword(s):  
Drug Therapy ◽  
System Approach ◽  
Biological Fluids ◽  
Comprehensive Analysis ◽  
Plasma Metabolites ◽  
Therapeutic Drug ◽  
The Novel ◽  
History Of ◽  
Direct Mass Spectrometry

The review is devoted to pharmacometabonomics - a new branch of science focused on personalization of drug therapy through the comprehensive analysis of metabolites of patient's biological fluids. It considers the history of pharmacometabonomic, positioning to other “-omic” sciences, and system approach, realized by this science, in determination of individual therapeutic dose of the drugs and also a technical implementation of pharmacometabonomic based on direct mass spectrometry of blood plasma metabolites. Special attention is paid to a comparative analysis of pharmacometabonomics and other main approaches to personalized therapy in the clinic, such as pharmacogenetics and therapeutic drug monitoring. Finally, prospects of pharmacometabonomics applications in clinical practice were also discussed.

scholarly journals INFLUENCE OF ALKALINE – EARTH METALS ON ANODIC BEHAVIOR OF ALLOY ССУЗ IN NEUTRAL ENVIRONMENT OF THE ELECTROLYTE NaCl

2018 ◽  
pp. 84-89
Author(s):  
I. N. Ganiev ◽  
O. Kh. Niyezov ◽  
N. M. Mulloeva ◽  
B. B. Eshov
Keyword(s):  
Corrosion Rate ◽  
Current Density ◽  
Alkaline Earth ◽  
Chloride Ion ◽  
Sweep Rate ◽  
Potential Sweep Rate ◽  
Alkaline Earth Metals ◽  
Anodic Behavior ◽  
Potential Sweep ◽  
Antimony Alloy

The anodic behavior of a lead-antimony alloy (3 wt% Sb) doped with alkaline-earth metals was investigated in potentiostatic method in the potentiodynamic mode at a potential sweep rate of 2 mV/s and it was shown that with an increase in the content of alkaline earth metals in the alloy (SSUZ), the potentials of free Corrosion and pitting are slightly shifted to the positive region. As the concentration of the chloride ion in the electrolyte increases, these potentials decrease. The current density of corrosion and, accordingly, the corrosion rate of alloys with an increase in the content of alkaline earth metals are reduced by 75–85%, and the concentration of chloride ion increases.In transition from alloys with calcium to alloys with strontium, the corrosion rate of alloys increases by 20–30%, and to alloys with barium it decreases by 25–30%.

scholarly journals Anodic behaviour of Zn0.5Al doped with molybdenum in acidic, neutral and alkaline media

2021 ◽  
Vol 11 (2) ◽  
pp. 187-194
Author(s):  
Z. R. Obidov ◽  
P. R. Ibrohimov ◽  
F. A. Rahimov ◽  
I. N. Ganiev
Keyword(s):  
Sweep Rate ◽  
Potential Sweep Rate ◽  
Alkaline Media ◽  
Favourable Effect ◽  
Neutral Medium ◽  
Potential Sweep ◽  
Stationary Potential ◽  
Zinc Alloys ◽  
Anodic Behaviour ◽  
Acidic And Alkaline Media

The paper presents the results of a potentiodynamic study of the anodic behaviour of Zn0.5Al doped with molybdenum in the acidic (0.1 M, pH = 1; 0.01 M, pH = 2; 0.001 M, pH = 3), neutral (0.03, 0.3, 3%, pH = 7) and alkaline (0.001 M, pH = 10; 0.01 M, pH = 11; 0.1 M, pH = 12) media of HCl, NaCl and NaOH electrolytes. In the potentiodynamic mode with an electrode potential sweep rate of 2 mV/s, all Zn0.5Al-Mo samples containing from 0.01 to 1.0 wt% of molybdenum demonstrated a shift in the potentials of corrosion, pitting formation and repassivation. These potentials shift towards negative values in acidic and alkaline media, while shifting to positive values in a neutral medium. It was established that an increase in the concentration of electrolytes led to a shift of all the considered potentials towards negative values in all media - acidic, neutral and alkaline. This dependence is associated with the specific features of the process of anodic dissolution of alloys during the formation of an oxide film on their surface. The significance of the dependence of the stationary potential of free corrosion of alloys on time for establishing the passivity of surfaces in acidic, neutral and alkaline media was shown. It was determined that zinc alloys doped with molybdenum are resistant to pitting corrosion in all the investigated media. This resistivity is particularly high in acidic (0.001 M), neutral (0.03%) and alkaline (0.001 M) media of HCl, NaCl and NaOH electrolytes. The favourable effect of molybdenum on both the anodic behaviour of Zn0.5Al and the overall increase in the corrosion resistance of alloys was demonstrated. In comparison with undoped Zn0.5Al alloys, the corrosion rate of alloys doped with molybdenum (0.01-1.0 wt%) is 2-2.5 times lower. The proposed compositions of Zn0.5Al-Mo alloys can be used as noncorrosive coatings for steel products.

Inhibitor binding assay for angiotensin-converting enzyme.

1984 ◽  
Vol 30 (5) ◽  
pp. 696-700 ◽  
Author(s):  
F Fyhrquist ◽  
I Tikkanen ◽  
C Grönhagen-Riska ◽  
L Hortling ◽  
M Hichens
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Binding Assay ◽  
Enzyme Inhibitor ◽  
Specific Binding ◽  
Biological Fluids ◽  
The Novel ◽  
Converting Enzyme ◽  
Inhibitor Binding ◽  
Standard Curve

Abstract We describe a new principle for the determination of enzymes, here applied to angiotensin-converting enzyme (ACE, EC 3.4.15.1) in human serum. The enzyme inhibitor binding assay is based on specific binding of labeled inhibitor to the active center of the enzyme. Serum (10-15 microL) is incubated with 125I-labeled ACE inhibitor (" 351A ," a p- hydroxybenzamidine derivative of N-(1-carboxy-3-phenylpropyl)-L-lysyl-L-proline) at pH 7.0 at 37 degrees C for 2 h in a non-equilibrated system. Inhibitor bound to ACE is separated by adsorption to coated charcoal, the radioactivity remaining in the supernate is counted, and the ACE value is calculated from a standard curve. Sensitivity for ACE in serum is 200 U/L, corresponding to 5.0 ng of ACE purified from human lung. The coefficient of variation was 3.9% within assay, and 6.4% between assays for normal ACE activities. Correlation with a comparison spectrophotometric method (Am J Med 59: 363-372, 1975) for ACE assay was excellent (r = 0.98) in 59 samples from healthy subjects and from patients with various diseases including active sarcoidosis. The novel assay principle presented here is simple and specific, and can be extended to use with various biological fluids and tissues, and to other enzymes as well.

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