scholarly journals Association of NQO1 C609T (Pro187Ser) with Risk of Oral Submucous Fibrosis in Eastern Indian Population

2021 ◽  
Vol 6 (3) ◽  
pp. 187-193
Author(s):  
Sanjit Mukherjee ◽  
Sweta Mohanty ◽  
Atul Katarkar ◽  
Richa Dhariwal ◽  
Basudev Mahato ◽  
...  
Keyword(s):  
Indian Population ◽  
Oral Submucous Fibrosis ◽  
Transformation Rate ◽  
Areca Nut ◽  
Quinone Oxidoreductase ◽  
Increased Risk ◽  
Pcr Rflp ◽  
Submucous Fibrosis ◽  
Nqo1 C609t Polymorphism

Objective: Oral submucous fibrosis (OSF) is a debilitating disease mainly attributed to chewing areca nut with a 7.4-13% malignant transformation rate. The present study explores the role of NADPH quinone oxidoreductase 1 (NQO1) C609T (Pro187Ser) polymorphism in susceptibility to OSF among habitual areca nut chewers in an eastern Indian population. Material and Methods: In this hospital-based study, 152 controls and 179 OSF cases were genotyped at NQO1 C609T polymorphic site by PCR-RFLP and its effect on NQO1 expression in OSF tissue was studied to determine the risk of the disease. Results: Overall, about 18% of the total OSF cases were detected carrying minor TT alleles (Ser/Ser) p=0.026. When categorized by age, both CT (Pro/Ser) and TT (Ser/Ser) alleles were significantly higher (p= 0.003 & 0.004 respectively) in cases above 40years of age. NQO1 protein was 42% reduced in buccal tissues of heterozygous (Pro/Ser) carriers, whereas a 70% reduction was observed in TT (Ser/Ser) OSF cases. Conclusion: Our study suggests that the NQO1 C609T polymorphism confers increased risk for OSF in habitual chewers. 

scholarly journals Role of Hemoglobin and Serum Iron in Oral Submucous Fibrosis: A Clinical Study

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Hegde Karthik ◽  
Preeti Nair ◽  
Harshkant P. Gharote ◽  
Kavita Agarwal ◽  
Guruprasad Ramamurthy Bhat ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Serum Iron ◽  
Oral Submucous Fibrosis ◽  
Nutritional Deficiencies ◽  
Transformation Rate ◽  
Areca Nut ◽  
Healthy Individuals ◽  
Submucous Fibrosis ◽  
Hematological Abnormalities

Background. Oral submucous fibrosis is a chronic, insidious oral mucosal condition affecting the most parts of the oral cavity with high malignant transformation rate triggered by areca nut chewing, nutritional deficiencies, immunologic processes, and genetic predisposition. OSF causes significant hematological abnormalities resulting in anemia and a decrease in serum iron levels.Aim. The aim of this study was to estimate the hemoglobin and serum iron levels among patients with oral submucous fibrosis and to compare the values with healthy subjects.Materials and Methods. In this hospital-based study 30 diagnosed patients of OSMF and 15 healthy individuals were included, and the values of hemoglobin and serum iron levels were estimated using Sahli’s and Ferrene methods.Results. OSMF patients showed significantly lower levels of hemoglobin and serum iron when compared with the healthy subjects.Conclusion. The findings of the study emphasizes on the assessment of hemoglobin and serum iron for patients with oral submucous fibrosis. Also iron therapy should be instituted concomitantly with the initial diagnosis which helps to cease the further progression of the condition. Further extensive studies are indicated to understand the correlation between OSMF and iron deficiency.

scholarly journals Association of NQO1 C609T (Pro187Ser) with risk of Oral Submucous Fibrosis in Eastern Indian population

2016 ◽  
Author(s):  
Sanjit Mukherjee ◽  
Atul Katarkar ◽  
Jay Gopal Ray ◽  
Keya Chaudhuri
Keyword(s):  
Indian Population ◽  
Oral Submucous Fibrosis ◽  
Quinone Oxidoreductase ◽  
Submucous Fibrosis ◽  
Probable Role

AbstractPresent study explores the role of NADPH quinone oxidoreductase 1 (NQO1) C609T (Pro187Ser) polymorphism in susceptibility to and its probable role in malignant potentiality of Oral submucous fibrosis (OSF) a debilitating disease caused mainly by chewing arecanut. About 18% of the patients were detected with minor TT allele (Ser/Ser) p=0.026, while both CT (Pro/Ser) and TT (Ser/Ser) allele, p= 0.003 & 0.004 respectively, was found to be higher in patients above 40yrs of age. NQO1 protein was 42% reduced in buccal tissues of heterozygous (Pro/Ser) carriers, whereas a 70% reduction was observed in TT (Ser/Ser) patients. Decrease in NQO1 activity was noted in both in OSF tissues alone or when associated with malignancy.

scholarly journals Role of Areca Nut Induced TGF-β and Epithelial-Mesenchymal Interaction in the Pathogenesis of Oral Submucous Fibrosis

PLoS ONE ◽  
2015 ◽  
Vol 10 (6) ◽  
pp. e0129252 ◽  
Author(s):  
Ila Pant ◽  
Neeraj Kumar ◽  
Imran Khan ◽  
Somanahalli Girish Rao ◽  
Paturu Kondaiah
Keyword(s):  
Oral Submucous Fibrosis ◽  
Areca Nut ◽  
Submucous Fibrosis

A case-control study of oral submucous fibrosis with special reference to the etiologic role of areca nut

1990 ◽  
Vol 19 (2) ◽  
pp. 94-98 ◽  
Author(s):  
P. N. Sinor ◽  
P. C. Gupta ◽  
P. R. Murti ◽  
R. B. Bhonsle ◽  
D. K. Daftary ◽  
...  
Keyword(s):  
Special Reference ◽  
Case Control Study ◽  
Oral Submucous Fibrosis ◽  
Case Control ◽  
Areca Nut ◽  
Etiologic Role ◽  
Submucous Fibrosis ◽  
Control Study

Etiology of oral submucous fibrosis with special reference to the role of areca nut chewing

1995 ◽  
Vol 24 (4) ◽  
pp. 145-152 ◽  
Author(s):  
P. R. Murti ◽  
R. B. Bhonsle ◽  
P. C. Gupta ◽  
D. K. Daftary ◽  
J. J. Pindborg ◽  
...  
Keyword(s):  
Special Reference ◽  
Oral Submucous Fibrosis ◽  
Areca Nut ◽  
Submucous Fibrosis

Role of Areca nut in oral submucous fibrosis

2017 ◽  
Vol 7 (1) ◽  
pp. 1
Author(s):  
MohseenRafik Kazi ◽  
AmishaA Shah ◽  
AjitV Koshy ◽  
SharmeenF Shaikh
Keyword(s):  
Oral Submucous Fibrosis ◽  
Areca Nut ◽  
Submucous Fibrosis

scholarly journals Oral submucous fibrosis: a contemporary narrative review with a proposed inter-professional approach for an early diagnosis and clinical management

2020 ◽  
Vol 49 (1) ◽  
Author(s):  
Naman R. Rao ◽  
Alessandro Villa ◽  
Chandramani B. More ◽  
Ruwan D. Jayasinghe ◽  
Alexander Ross Kerr ◽  
...  
Keyword(s):  
Oral Submucous Fibrosis ◽  
High Morbidity ◽  
Transformation Rate ◽  
Areca Nut ◽  
Effective Management ◽  
Asian Countries ◽  
Main Risk Factor ◽  
Submucous Fibrosis ◽  
Professional Model ◽  
Transformation Rate Constant

AbstractOral Submucous fibrosis (OSMF) has traditionally been described as “a chronic, insidious, scarring disease of the oral cavity, often with involvement of the pharynx and the upper esophagus”. Millions of individuals are affected, especially in South and South East Asian countries. The main risk factor is areca nut chewing. Due to its high morbidity and high malignant transformation rate, constant efforts have been made to develop effective management. Despite this, there have been no significant improvements in prognosis for decades. This expert opinion paper updates the literature and provides a critique of diagnostic and therapeutic pitfalls common in developing countries and of deficiencies in management. An inter-professional model is proposed to avoid these pitfalls and to reduce these deficiencies.

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