Chemical Peels: Wound Treatment for up to Three Months Post Peel Recuperative Phase.

2017 ◽  
Vol 1 (1) ◽  
pp. 01-03
Author(s):  
Luke Jackson ◽  
Ethan Nicholas ◽  
Robert Mason ◽  
Landon Owen

The cutaneous ageing process whether skin laxity, facial wrinkles, ageing pigmantory spots is a continuous process which is invariably difficult to stop, despite the recent advances in science and medicine. Moreover, to combat the signs of ageing, chemical peels may be used to help ameliorate the scars, to destroy premalignant and/or malignant lesions, unsightly pigmentation etc. The treatment modalities used to produce a controlled injury are dermabrasion, chemical peels and photoepilation (laser and intense pulse light) therapy. Only if the injury is in the proper tissue plane can the desired result be achieved. If too superficial, the results will be disappointing. If too deep, the results can be catastrophic. The chemical peeling creates a controlled injury in an attempt to correct a particular problem. Historically, various chemical peels used such as phenol, trichloroacetic acid as single agent or in combination. Recently, newer agents have been introduced into the world of chemical peeling. These newer agents are used in combination for resistant hyperpigmentation or combined with intense pulse light microdermabrasion for acne scarring to achieve satisfactory results.

2011 ◽  
Vol 27 (4) ◽  
pp. 263-265 ◽  
Author(s):  
Wendy W. Lee ◽  
Jennifer Murdock ◽  
Thomas A. Albini ◽  
Terrence P. OʼBrien ◽  
Michael L. Levine

2017 ◽  
Vol 3 ◽  
pp. 205951311769531 ◽  
Author(s):  
Georgios Kravvas ◽  
Firas Al-Niaimi

[Formula: see text] Introduction: Acne is a common condition that can result in permanent scarring. Acne scars can be broken down into three categories: atrophic; hypertrophic; and keloidal. Atrophic scars can be further sub-classified into: ice pick; rolling; and boxcar. Objectives and Methods: We have performed a comprehensive literature search of the last ten years in order to determine the efficacy and adverse reactions of commonly used treatments against post-acne scarring. Results: A total of 36 relevant articles were identified on the following interventions: subcision (n = 10), dermabrasion (n = 1), microneedling (n = 8), dermal fillers (n = 5), and chemical peeling (n = 12). Discussion: Improvement in the appearance of post-acne scarring following subcision is in the range of 10–100%. Microdermabrasion achieved the least significant results. A total of 27.3% patients did not achieve any benefit despite eight treatment sessions, and only 9.1% achieved good results. All patients treated with microneedling achieved some improvement in scar appearance in the range of 31–62%. Dermal fillers also led to favourable outcomes. In particular, treatment with PPMA led to improvement in 84% of patients. Utilising chemical peels, trichloroacetic acid (TCA) CROSS achieved >70% improvement in 73.3% of patients, whereas 20% glycolic acid did not lead to any improvement in 25%. Conclusion: Post-acne scarring is a common and challenging condition with no easy and definitive solution. The above interventions have been used with varying degrees of efficacy, each having both pros and cons. All have been deemed to be safe with few and transient adverse reactions. However, further trials with a larger number of patients are necessary in order to reach more concrete conclusions regarding their efficacy.


Author(s):  
Dr Munir Alam

Background/Objectives: The chemical peels may be used to help ameliorate the scars, to destroy premalignant and /or malignant lesions, unsightly pigmentation etc. The treatment modalities used to produce a controlled injury are dermabrasion, chemical peels and photoepilation (LASER and IPL). Only if the injury is in the proper tissue plane can the desired result be achieved. If too superficial, the results will be disappointing. If too deep, the results can be catastrophic. Material and Methods: The author has introduced newer formula into the world of chemical peeling according to the depth of peeling agent penetration. Superficial        Medium                           Deep TCA 15 gm        TCA 10 gm                       TCA 35 gm Croton oil          Mandelic acid 5 gm         Septisol Sesame oil        Salicylic acid 15 gm         Glyserine Distill water      Sesame oil                        Croton oil                            Croton oil                         Distill water                            Distill water PAKPEEL   This is a prospective study of 3 years from Aug 2016 to Aug 2019. In this study, total number of 216 consecutive chemical peels on 54 patients over a 3-year period were performed. Age distribution ranges from 20 years to 55 years. Results: The results achieved with these newer chemical formula are highly satisfactory (80-90%) for almost all skin conditions treated. Conclusion: In our office setting practice, we perform approximately four sessions of chemical peel weekly and continue skin lightening/spot protection creams and sun protection. This study corroborate evidence superiority of our selected chemical formula.


2020 ◽  
Vol 40 (5) ◽  
pp. 1135-1141
Author(s):  
Serap Yurttaser Ocak ◽  
Sezen Karakus ◽  
Osman Bulut Ocak ◽  
Akın Cakir ◽  
Selim Bolukbasi ◽  
...  

2016 ◽  
Vol 1 (2) ◽  
Author(s):  
Yan Teng Khoo ◽  
Ahmad Sukari Halim

<p>Skin hyperpigmentation involves a broad range of skin conditions, including epidermal pigmented lesions, dermal pigmented lesions, and mixed pigmented lesions. Treatment includes various modalities such as brightening cream, chemical peeling, and laser therapy. Responses to various treatment modalities can be quite varied depending on the type of treatment and the degree of pigmentation. Sometimes a lesion can lighten or even partially disappear, while other lesions may recur. This paper provides a brief overview of treatment modalities available for hyperpigmented skin lesions including the importance of photoprotection, various types of brightening creams, suitable types of chemical peels, specific laser therapies targeted for skin hyperpigmentation, and surgery.</p>


Cancers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 2708
Author(s):  
Alice Boilève ◽  
Marc Hilmi ◽  
Matthieu Delaye ◽  
Annemilaï Tijeras-Raballand ◽  
Cindy Neuzillet

Hepatocellular carcinoma (HCC) and biliary tract cancers (BTC) exhibit a poor prognosis with 5-year overall survival rates around 15%, all stages combined. Most of these primary liver malignancies are metastatic at diagnostic, with only limited therapeutic options, relying mainly on systemic therapies. Treatment modalities are different yet partially overlapping between HCC and BTC. The complex molecular profile of BTC yields to several actionable therapeutic targets, contrary to HCC that remains the field of antiangiogenic drugs in non-molecularly selected patients. Immunotherapy is now validated in the first line in HCC in combination with bevacizumab, while clinical activity of single agent immunotherapy appears limited to a subset of patients in BTC, still poorly characterized, and combinations are currently under investigation. In this review, we provide a critical evaluation and grading of clinical relevance on (i) the main prognostic biomarkers in HCC and BTC, (ii) the main theragnostic biomarkers in both tumors, and lastly (iii) what is recommended in clinical practice.


2015 ◽  
Vol 29 (9) ◽  
pp. 1661-1678 ◽  
Author(s):  
M. Adamič ◽  
M.D. Pavlović ◽  
A. Troilius Rubin ◽  
M. Palmetun-Ekbäck ◽  
P. Boixeda

2022 ◽  
Vol 11 ◽  
Author(s):  
Timothy C. Frommeyer ◽  
Craig A. Rohan ◽  
Dan F. Spandau ◽  
Michael G. Kemp ◽  
Molly A. Wanner ◽  
...  

The occurrence of non-melanoma skin cancer (NMSC) is closely linked with advanced age and ultraviolet-B (UVB) exposure. More specifically, the development of NMSC is linked to diminished insulin-like growth factor-1 (IGF-1) signaling from senescent dermal fibroblasts in geriatric skin. Consequently, keratinocyte IGF-1 receptor (IGF-1R) remains inactive, resulting in failure to induce appropriate protective responses including DNA repair and cell cycle checkpoint signaling. This allows UVB-induced DNA damage to proliferate unchecked, which increases the likelihood of malignant transformation. NMSC is estimated to occur in 3.3 million individuals annually. The rising incidence results in increased morbidity and significant healthcare costs, which necessitate identification of effective treatment modalities. In this review, we highlight the pathogenesis of NMSC and discuss the potential of novel preventative therapies. In particular, wounding therapies such as dermabrasion, microneedling, chemical peeling, and fractionated laser resurfacing have been shown to restore IGF-1/IGF-1R signaling in geriatric skin and suppress the propagation of UVB-damaged keratinocytes. This wounding response effectively rejuvenates geriatric skin and decreases the incidence of age-associated NMSC.


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