INTRAVENOUS INTRODUCTION OF NOVOKAYA IN THE UNDERSTANDING OF CANCER

2019 ◽  
Vol 237 (1) ◽  
pp. 10-14
Author(s):  
A.V. Aldyakov ◽  
◽  
I.O. Efimova ◽  
◽  
◽  
...  
Keyword(s):  
Intravenous Introduction

scholarly journals A STUDY OF RENAL SECRETION DURING TARTRATE NEPHRITIS

1913 ◽  
Vol 18 (4) ◽  
pp. 347-352 ◽  
Author(s):  
Frank P. Underhill ◽  
H. Gideon Wells ◽  
Samuel Goldschmidt
Keyword(s):  
Sodium Chloride ◽  
Normal Animal ◽  
The Other ◽  
Tubular Epithelium ◽  
Histological Findings ◽  
Renal Secretion ◽  
Experimental Conditions ◽  
Convoluted Tubules ◽  
Intravenous Introduction ◽  
Direct Confirmation

After the intravenous introduction of a solution containing sodium chloride and urea into the rabbit during pronounced tartrate nephritis, all the chloride reappears in the urine within forty-eight hours. On the other hand, the nitrogen of the urine remains far below that usually eliminated by the normal animal under the experimental conditions; in other words, little or none of the urea injected is excreted by the kidney. In the light of the histological findings these results are interpreted to mean that under normal conditions chlorides and water are passed through the glomerular mechanism, whereas urea becomes a urinary constituent by way of the convoluted tubules. These results constitute a direct confirmation of the older observations of others concerning the elimination by the kidney of the substances under discussion. No evidence was obtained that the glomerulus may take over the function of the tubular epithelium.

INITIAL EXPERIENCE 13N-AMMONIA APPLICATION AND PERSPECTIVES FOR ITS CLINICAL USE IN NEUROONCOLOGY

2018 ◽  
Vol 64 (4) ◽  
pp. 515-521
Author(s):  
Nikolay Kostenikov ◽  
Olga Mirolyubova ◽  
Violetta Dubrovskaya ◽  
Yuriy Ilyushchenko ◽  
Andrey Stanzhevskiy
Keyword(s):  
Malignant Tumors ◽  
Emission Tomography ◽  
Benign Tumors ◽  
Initial Experience ◽  
Tumor Vascularization ◽  
Positron Emission ◽  
Pet Ct ◽  
Hypervascular Tumors ◽  
Malignant And Benign Tumors ◽  
Intravenous Introduction

Materials and methods. A group of 19 patients with suspected of recurrent growth malignant and benign tumors and postoperative cysts on PET-CT with 13N-ammonium were examined in the postoperative period. The RPH 13N-ammoniа was injected intravenously at the dose of 350-370MBq/m2 of body surface. It is shown, that PET with 13N-ammonia allows to clearly visualize benign and malignant hypervascular tumors, as well as to assess the efficiency of their treatment. The tendency was detected for prevalence of the increased accumulation of 13N-ammonia in benign hypervascular neoplasms of a vascular line as compared to malignant tumors. That is explained by the dependence of the uptake of the drug both upon the degree of tumor vascularization and upon the presence and concentration of glutamine in tumor cells. It is stated in the paper that the level of the uptake of 13N-ammonium in the tumor is in direct ratio to its perfusion and inversely to the degree of its malignancy. In case of effective treatment the level of accumulation of 13N-ammonia in malignant tumors is nonlinearly increased since the rate of metabolic processes is decreased that leads to accumulation of glutamine, however perfusion in the tumor is also nonlinearly decreased. Conclusion. Ultrashort half-life of the radionuclide [13N] (of 9.96 min) and the low radiation exposure that occurs with intravenous introduction of 13N-ammonium create a unique opportunity for diagnosis and assessment of the efficiency of treatment of brain tumors by the method of positron emission tomography.

ACID-SOLUBLE PHOSPHORUS COMPOUNDS AND FREE SUGARS IN FISH MUSCLE AND THEIR ORIGIN

1962 ◽  
Vol 40 (1) ◽  
pp. 571-589 ◽  
Author(s):  
H. L. A. Tarr ◽  
M. Leroux
Keyword(s):  
Fish Muscle ◽  
Phosphorus Compounds ◽  
Post Mortem ◽  
Exchange System ◽  
Shunt System ◽  
Free Sugars ◽  
Fish Muscles ◽  
Sugar Phosphates ◽  
Hydrolysis Of ◽  
Intravenous Introduction

An ion-exchange system capable of separating the principal sugar phosphates and nucleotides in fish muscles was developed and used to study the distribution of these in muscles of freshly killed fish, and in certain of these muscles after several days at 0 °C. The results indicate that there are extreme quantitative variations in these compounds. Intravenous introduction of C14-labelled glucose or G6P* into salmonoid fish results in rapid labelling of glycolytic intermediates such as F6P, FDP, and lactate in both muscle and liver. Evidence was obtained, using C14fish muscle glycogen, which indicates that this substance is degraded to maltose and glucose post mortem both by an amylase and by the Embden–Meyerhof system, and that very little glucose arises by hydrolysis of G6P. When introduced into fish muscle post mortem, C14ATP yielded radioactive IMP and ribose, G6P and glucose being unlabelled. Radioactive R5P (or ribose) was never found in muscle of fish injected with C14-labelled glucose or G6P, indicating that these are not formed via the hexosemonophosphate shunt system. R5P was not found in muscle of living fish and only in comparatively small amounts post mortem. Evidence is presented which shows that F1P does not occur in appreciable amounts in fish muscles, and that the evidence so far presented in support of the occurrence of R1P is unsatisfactory.

scholarly journals Influence nanoparticles on morphology of internal organsof the mouse at intravenous introduction of a solution nanopowder Fe3O4

2008 ◽  
Vol 7 (1) ◽  
pp. 32-36
Author(s):  
I. V. Milto ◽  
G. A. Mikhaylov ◽  
A. V. Ratkin ◽  
A. A. Magaeva
Keyword(s):  
The Given ◽  
Intravenous Introduction ◽  
Adaptive Reactions

The influence nanoparticles Fe3O4 on morphology of the vital organs of the mouse after unitary intravenous introduction of a solution nanopowder Fe3O4 has been investigated. Change of morphology of the studied organs has been established, it testifies about adaptive reactions of an organism of mice to intravenous introduction nanopowder which outcome at the given stage is difficult for predicting.

Effect of Intravenous Blood Thromboplastin Intermediates on Clotting in Rats

1958 ◽  
Vol 195 (1) ◽  
pp. 77-80 ◽  
Author(s):  
Theodore H. Spaet ◽  
Mona Kropatkin
Keyword(s):  
Anticoagulant Activity ◽  
Cellular Mechanism ◽  
Intravenous Injections ◽  
Coagulant Activity ◽  
Intravenous Introduction

Rats were given intravenous injections of blood thromboplastin intermediates. Fully formed blood thromboplastin and product II of Bergsagel and Hougie produced the defibrination syndrome, whereas thromboplastin generation reagents singly or in combination were tolerated without adverse sympatomatic or coagulation effects. In the latter case, there was no evident elevation of blood anticoagulant activity. It is concluded that protection against the intravenous introduction of potential coagulants exceeds that to be accounted for by circulating anticoagulants. A cellular mechanism is hypothesized which clears circulating blood of potential coagulant activity.

Metabolism, Distribution, and Disappearance of Infected β-Phenylethylamine in the Rat

1975 ◽  
Vol 53 (1) ◽  
pp. 42-50 ◽  
Author(s):  
P. H. Wu ◽  
Alan A. Boulton
Keyword(s):  
Monoamine Oxidase ◽  
Intravenous Injection ◽  
Phenylacetic Acid ◽  
Monoamine Oxidase Inhibitor ◽  
Brain Regions ◽  
Oxidase Inhibitor ◽  
Presence And Absence ◽  
Intravenous Introduction

In the absence of a monoamine oxidase inhibitor, the bulk of intravenously injected radioactively labelled β-phenylethylamine was oxidized to phenylacetic acid. In the presence of pargyline, most of the label in tissues remained as unchanged phenylethylamine; small amounts of labelled phenylethanolamine, tyramine and octopamine were also identified. After intravenous injection of [14C]phenylalanine, only very small amounts of [14C]phenylethylamine could be located in urine and faeces. β-Phenylethylamine became concentrated in all tissues, including brain, following intravenous introduction both in the presence and absence of pargyline. Its clearance from these tissues and from brain regions was very fast.

Stochastic modeling of human RBC alloimmunization: evidence for a distinct population of immunologic responders

Blood ◽  
2008 ◽  
Vol 112 (6) ◽  
pp. 2546-2553 ◽  
Author(s):  
John M. Higgins ◽  
Steven R. Sloan
Keyword(s):  
Large Scale ◽  
Common Disease ◽  
Human Response ◽  
Distinct Population ◽  
Disease States ◽  
Increased Risk ◽  
Genetically Determined ◽  
Intravenous Introduction ◽  
Rbc Transfusion ◽  
Weakly Dependent

Abstract Red blood cell (RBC) transfusion is unique as a common large-scale intravenous introduction of foreign tissue and provides a valuable opportunity to study human immunologic response to intravenous foreign antigen. Patients receiving RBC transfusions are at risk of forming alloantibodies against donor RBC antigens, and valid estimates of alloimmunization risk are clinically important, but little is known about the factors governing this risk or, more generally, about determinants of human response to intravenous antigen. Here, we mine large electronic patient databases enabling us to model RBC alloimmunization as a stochastic process. We identify a subgroup of transfusion recipients that has a dramatically increased risk of alloimmunization that appears to be genetically determined because it is independent of common disease states, patient age, or the number of alloantibodies already formed, and only weakly dependent on transfusion count.

Sign in / Sign up

Export Citation Format

Share Document