scholarly journals The Condition of Post-Vaccination Immunity to the Tick-Borne Encephalitis Virus in the Population Highly Endemic Area with Siberian Subtype Domination

2018 ◽  
Vol 17 (2) ◽  
pp. 27-36 ◽  
Author(s):  
M. S. Shcherbinina ◽  
V. V. Pogodina ◽  
S. M. Skrynnik ◽  
L. S. Levina ◽  
N. G. Bochkova ◽  
...  
Keyword(s):  
Endemic Area ◽  
Optimal Number ◽  
Scientific Center ◽  
Neutralizing Activity ◽  
Degree Of Protection ◽  
Tick Borne Encephalitis ◽  
Tbe Virus ◽  
Natural Foci ◽  
Neutralization Index ◽  
Siberian Subtype

Relevance.Modern inactivated culture vaccines against tick-borne encephalitis (TBE) with at least 70% of the population living in the  natural foci of the FE give a high epidemiological effect. Unresolved  issues are the simplification of the cumbersome vaccination scheme,  the optimal number of revaccinations, the protective titer of  antibodies against the Siberian subtype of the TBE virus dominant in Russia.Goalof this work is to study the state of postvaccinal immunity in the population of the highly endemic area of the Trans-Urals.Materials and methods. 1381 blood serum of the population vaccinated from 3 to 13 times with vaccines was studied: unconcentrated culture inactivated from strain No. 205 of the TBE  virus produced by «Virion», Tomsk, «EnceVir» produced by  «Microgen», Tomsk, produced by Chumakov Federal Scientific Center for Research and Development of Immuneand-Biological Products of  Russian.To identify specific antibodies – IgG, IgM, antigen of TBE  virus, sets of reagents of ELISA from «Vector-Best» were used.  Neutralizing activity of sera was determined by the index of  neutralization index with 4 strains of the Siberian subtype of TBE  virus.Results.The immune layer among the vaccinated population in 10 districts of the Kurgan region, which differ in epidemiological tension, ranges from 69.9% to 94.6%. The intensity of humoral immunity  varied according to IgG titers in ELISA from 1: 100 – 1: 200 to 1:  3200 (rarely 1: 6400). The duration and intensity of immunity  depends on the number of vaccinations and the number of missed  remote revaccinations. Preservation and intensity of immunity with  reliability P = 95%, higher in persons vaccinated 6–10 times  compared with the group of vaccinated 3 times. In persons who had 4–8 booster dose of vaccine, the immunity persisted for 15–19–36 years with an IgG titer of not more than 1: 100. The neutralizing  activity of the sera of vaccinated individuals with antibody titers from 1:100 to 1: 6400 was studied for the Siberian subtype of BCE. The  degree of protection of the vaccinated population against the doses  of the virus found in individual mites is determined. From the doses  of the virus, 57% of the vaccinated population are most often found  in mites, and from the dose of 105– 8%. Recommendations are  proposed on the tactics of revaccination of the population, depending on the level of immunity.

scholarly journals The features of tick-borne encephalitis in the Yaroslavl region at the present stage. The problem of evolution of the infection

2014 ◽  
Vol 19 (4) ◽  
pp. 37-44
Author(s):  
S. G Gerasimov ◽  
T. A Druzhinina ◽  
L. S Karan ◽  
N. M Kolyasnikova ◽  
N. S Baranova ◽  
...  
Keyword(s):  
High Frequency ◽  
Federal District ◽  
Total Percentage ◽  
Cyclical Fluctuations ◽  
Tick Borne Encephalitis ◽  
Tbe Virus ◽  
Average Annual Incidence ◽  
Natural Foci ◽  
Siberian Subtype ◽  
Epidemiological Significance

In the Yaroslavl region (Central Federal District of Russia), endemic of tick-borne encephalitis (TBE), the features of epidemiology of this infection were studied during 1992-2012. Cyclical fluctuations in the incidence of TBE, the lack of the trend to decrease of the incidence were observed, the average annual incidence was 1,6 ± 0,32 per 100 thousand ofpopulation. The prevalence offebrile forms of disease was 62,2%, meningeal forms - 16,3%, the total percentage offocal forms was 13,9%. Manifestations of evolution of TBE were: the increase of the epidemiological significance of anthropogenically transformed natural foci, anthropurgical foci of TBE, until 81% of TBE cases were unvaccinated citizens, the high lethality of 4% and the high frequency of cases of alimentary infection of TBE of 7,8% with lethality of 10,8%. The aethiological agent of 10 lethal cases was Siberian subtype of TBE virus.

scholarly journals Modern Problems of Tick-Borne Encephalitis Specific Prevention. Communication II: Peculiarity of Immunity in Area with Siberian Subtype Domination

2015 ◽  
Vol 14 (6) ◽  
pp. 65-73 ◽  
Author(s):  
V. V. Pogodina ◽  
M. S. Shcherbinina ◽  
L. S. Levina ◽  
S. G. Gerasimov ◽  
N. M. Kolyasnikova
Keyword(s):  
Far East ◽  
Inapparent Infection ◽  
The Far East ◽  
Tick Borne Encephalitis ◽  
Tbe Virus ◽  
Siberian Subtype

Siberian subtype of TBE virus dominates in the most part of Russia outside of the Far East. Peculiarity of immunity induced by Siberian subtype during disease or inapparent infection and change of immunity after vaccination are described in this article. Protective titre of antibodies and persistence of TBE virus (TBEV) in vaccinated organism are discussed.

The presence of tick-borne encephalitis in an endemic area for tick-borne diseases, Turkey

2008 ◽  
Vol 38 (1) ◽  
pp. 27-28 ◽  
Author(s):  
Berrin Esen ◽  
Aysegul Gozalan ◽  
Nilay Coplu ◽  
Fatih Sua Tapar ◽  
Ramazan Uzun ◽  
...  
Keyword(s):  
Immunoglobulin G ◽  
Endemic Area ◽  
Immunoglobulin M ◽  
Haemorrhagic Fever ◽  
Tick Borne Encephalitis ◽  
Tbe Virus ◽  
Crimean Congo Haemorrhagic Fever

The aim of this study was to indicate the presence of tick-borne encephalitis (TBE) in an endemic area for Crimean-Congo haemorrhagic fever (CCHF) in Turkey. Of 39 CCHF suspected cases, one was found to be TBE virus Immunoglobulin M positive and seven were TBE virus immunoglobulin G positive. It is important to report this first appearance of the TBE virus in Turkey since 1967.

scholarly journals Unusual case of lethal tick-borne encephalitis in patient vaccinated with vaccines produced from different viruses strains (the Chelyabinsk Region)

2015 ◽  
Vol 20 (1) ◽  
pp. 56-64 ◽  
Author(s):  
V. V Pogodina ◽  
S. V Luchinina ◽  
O. N Stepanova ◽  
E. A Stenko ◽  
A. N Gorfinkel ◽  
...  
Keyword(s):  
Genetic Difference ◽  
Virus Antigen ◽  
First Case ◽  
Tick Borne Encephalitis ◽  
Tbe Virus ◽  
Inactivated Vaccines ◽  
Chelyabinsk Region ◽  
Immunofluorescent Test ◽  
Far Eastern ◽  
Siberian Subtype

Lethal cases of tick-borne encephalitis in previously vaccinated patients have not been described. Modern inactivated vaccines against Tick-borne encephalitis (TBE) are high effective. The TBE cases, preference unfocal forms, are developed in persons with incomplete irregular vaccination. First case of lethal TBE after plural vaccination was described in the Kurgan region, the second case - in the Chelyabinsk region. These very rare unusual cases were studied. Being dominant the Siberian subtype of TBE virus is related with lethal TBE cases in the Chelyabinsk region. Unusual TBE case was developed in patient who had been vaccinated 8 limes with vaccines produced from strains of Far-Eastern TBE subtype («Virion», Tomsk, Chumakov institute, Moscow) and European TBE subtype (Encepur; FSME-Immun). Two years after the last vaccination a focal form of TBE was developed with lethal outcome at 9 th day. Specific antibodies IgM and IgG seroconversion were detected. The TBE virus antigen was detected in brain neurons by immunofluorescent test. Destructed neurons and gliocyles were shown by hystological study in cerebral hemispheres and cerebellum. The Purkinje cells were destructed. Possible reasons of surmounting vaccinal immunity including a genetic difference of vaccine and infection virus strains are discussed.

scholarly journals Biological properties and phylogenetic relationships of tick-borne encephalitis virus (Flaviviridae, Flavivirus) isolates of siberian subtype isolated in the south of East siberia in modern period

2021 ◽  
Vol 66 (4) ◽  
pp. 310-321
Author(s):  
O. V. Mel’nikova ◽  
R. V. Adel’shin ◽  
K. V. Lopatovskaya ◽  
Yu. T. Trushina ◽  
N. V. Yakovchits ◽  
...  
Keyword(s):  
Phylogenetic Relationships ◽  
Biological Properties ◽  
Encephalitis Virus ◽  
Ixodid Ticks ◽  
Enzyme Linked Immunosorbent Assay ◽  
East Siberia ◽  
Tick Borne Encephalitis ◽  
Natural Foci ◽  
Tick Borne Encephalitis Virus ◽  
Siberian Subtype

Introduction. Tick-borne encephalitis virus (TBEV) is medically most important representative of the same-name serogroup of genus Flavivirus (Flaviviridae). In the view of various researchers there are 3 to 5 TBEV subtypes, of them siberian being the most prevalent. The aim of the work is to compare the biological properties and to reveal phylogenetic relationships of large group of modern (2006–2019) TBEV isolates of siberian subtype from natural foci in southern East Siberia.Material and methods. Ixodid ticks (Ixodidae) and small mammals (Mammalia) from tick-borne encephalitis (TBE) natural foci in Irkutsk Region, Republic of Buryatia and Republic of Tuva, as well as specimens from TBE patients, were examined for TBEV markers using enzyme-linked immunosorbent assay (ELISA) and reverse transcription polymerase chain reaction (RT-PCR). Virus was isolated from suspensions with positive result, and its pathogenicity for white mice (Mus) (WM) was studied by different inoculation ways. Analysis of the nucleotide sequences of E gene was performed for isolates at 1st passage. Phylogenetic tree was constructed using MEGA X program.Results. The phylogenetic analysis has shown that TBEV of siberian subtype that circulates in natural foci of the studied territory belong to two genetic lines. These lines are «Vasilchenko» and «Zausaev» with a strong predominance of the first. The differences in biological properties between the two groups of strains have been demonstrated. Most of the strains from both groups showed high virulence for WM both after intracerebral and subcutaneous inoculation. Only four strains demonstrated the reduced ability to overcome the blood-brain barrier. However, the analysis of the E protein coding sequences revealed evident correlation between phylogenetic clustering and geographical origin of isolates, but not with TBE host or pathogenicity for WM.Conclusion. Further search for TBE genome regions associated with pathogenicity require the analysis of complete genome sequences of representative group of strains with different biological properties.

scholarly journals Modern Problems of Tick-Borne Encephalitis Specific Prevention Communication I: Vaccinal Prevention in Area with Siberian Virus Subtype Domination

2015 ◽  
Vol 14 (5) ◽  
pp. 77-84 ◽  
Author(s):  
V. V. Pogodina ◽  
M. S. Shcherbinina ◽  
S. G. Gerasimov ◽  
N. M. Kolyasnikova
Keyword(s):  
Far East ◽  
Eastern European ◽  
Review Of The Literature ◽  
The Far East ◽  
Tick Borne Encephalitis ◽  
Tbe Virus ◽  
The Central Nervous System ◽  
Far Eastern ◽  
Siberian Subtype ◽  
Virus Subtype

Tick-borne encephalitis (TBE) is a disease mainly affecting the central nervous system, serious medical and social problem in Russia and many European countries. TBE virus (TBEV) genetically divided into three major subtypes: the Far Eastern, European and Siberian. Siberian subtype of TBEV dominates in most part of Russia outside of the Far East. Modern cultural inactivated vaccine of domestic and foreign production prepared from the strains of the Far Eastern and European subtypes. In a review of the literature and our own researches are shown: the dominance of Siberian subtype (TBE) and data of vaccine-prevention. The importance of genetic differences between the Siberian subtype strains and vaccines strains are analyzed as well new approaches of the test strain selection.

TBE in Estonia

2019 ◽  
Author(s):  
Kuulo Kutsar
Keyword(s):  
Endemic Area ◽  
Endemic Country ◽  
Tick Borne Encephalitis ◽  
Vertebrate Hosts

The first cases of tick-borne encephalitis (TBE) in Estonia were identified in 1949. Today, Estonia is a TBE-endemic country. A TBE-endemic area in Estonia is defined as an area with circulation between ticks and vertebrate hosts as determined by detection of TBEV or the demonstration of autochthonous infections in humans or animals within the last 20 years.

TBE in Croatia

2020 ◽  
Keyword(s):  
Tick Species ◽  
Limited Data ◽  
Notifiable Disease ◽  
Genetic Characteristics ◽  
Central European ◽  
Tick Borne Encephalitis ◽  
Tbe Virus ◽  
Endemic Areas ◽  
European Subtype

Even though tick-borne encephalitis (TBE) has been a notifiable disease in Croatia since 2007, there are no or only limited data available on the occurring tick species in the endemic areas, on the prevalence of TBE virus (TBEV) in ticks, its distribution in Croatia, and its genetic characteristics. Reporting of human cases also is very scarce. The Central European subtype of virus (TBEV-EU) appears to be present in Croatia

TBE in Romania

2019 ◽  
Author(s):  
Lidia Chitimia-Dobler ◽  
Adriana Hristea ◽  
Wilhelm Erber ◽  
Tamara Vuković Janković
Keyword(s):  
Epidemiological Survey ◽  
Carpathian Mountains ◽  
Territorial Expansion ◽  
Tbe Virus ◽  
Natural Foci ◽  
Risk Areas

Based on an epidemiological survey performed, human TBE- virus neuroinfections may have an endemic emergent course, and natural foci are in full territorial expansion. Identified risk areas are Tulcea district, Transylvania, at the base of the Carpathian Mountains and the Transylvanian Alps.

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