scholarly journals Convection-enhanced delivery to the central nervous system

2015 ◽  
Vol 122 (3) ◽  
pp. 697-706 ◽  
Author(s):  
Russell R. Lonser ◽  
Malisa Sarntinoranont ◽  
Paul F. Morrison ◽  
Edward H. Oldfield
Keyword(s):  
Drug Delivery ◽  
Central Nervous System ◽  
Clinical Trials ◽  
Nervous System ◽  
Convective Flow ◽  
Clinical Applications ◽  
Systemic Delivery ◽  
Convection Enhanced Delivery ◽  
The Central Nervous System ◽  
Real Time Tracking

Convection-enhanced delivery (CED) is a bulk flow–driven process. Its properties permit direct, homogeneous, targeted perfusion of CNS regions with putative therapeutics while bypassing the blood-brain barrier. Development of surrogate imaging tracers that are co-infused during drug delivery now permit accurate, noninvasive real-time tracking of convective infusate flow in nervous system tissues. The potential advantages of CED in the CNS over other currently available drug delivery techniques, including systemic delivery, intrathecal and/or intraventricular distribution, and polymer implantation, have led to its application in research studies and clinical trials. The authors review the biophysical principles of convective flow and the technology, properties, and clinical applications of convective delivery in the CNS.

A Strategy to Develop a Finite Element Model to Represent Backflow During Infusions Into Brain Tissue

2011 ◽  
Author(s):  
Ana Belly Molano ◽  
José Jaime García ◽  
Joshua H. Smith
Keyword(s):  
Central Nervous System ◽  
Finite Element ◽  
Clinical Trials ◽  
Nervous System ◽  
Brain Tissue ◽  
Element Model ◽  
Therapeutic Agents ◽  
Convection Enhanced Delivery ◽  
Limited Efficacy ◽  
The Central Nervous System

Convection-enhanced delivery is a means to deliver therapeutic agents directly into brain tissue for the treatment of brain tumors and other disorders of the central nervous system. Unfortunately, recent clinical trials have demonstrated limited efficacy of this procedure and suggested that one of the main obstacles is poor distribution of the infused agent [1].

Revised Scaling Relationship for Backflow Distance Along an Infusion Catheter

2012 ◽  
Author(s):  
José Jaime García ◽  
Joshua H. Smith
Keyword(s):  
Central Nervous System ◽  
Clinical Trials ◽  
Nervous System ◽  
Therapeutic Agents ◽  
Convection Enhanced Delivery ◽  
Limited Efficacy ◽  
Scaling Relationship ◽  
Primary Obstacle ◽  
The Central Nervous System ◽  
The Brain

Convection-enhanced delivery (CED) is a means to deliver therapeutic agents directly into brain tissue for the treatment of brain tumors and other disorders of the central nervous system, such as Parkinson’s disease. Recent clinical trials have shown limited efficacy of this procedure, with poor distribution of the infused agent being the primary obstacle [1]. One of the challenges with improving the distribution is the effect of backflow, in which the infused fluid preferentially flows along the outside of the catheter toward the surface of the brain rather than through the tissue toward the desired region for delivery.

Nanoparticle-mediated Drug Delivery Systems (DDS) in the Central Nervous System

2016 ◽  
Vol 21 (3) ◽  
pp. 272-283 ◽  
Author(s):  
Guilong Zhang ◽  
Lukui Chen ◽  
Xiaoyuan Guo ◽  
Ahsan Khan ◽  
Yuchun Gu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Central Nervous System ◽  
Nervous System ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
The Central Nervous System

scholarly journals Nanoparticulate Systems for Drug Delivery and Targeting to the Central Nervous System

2010 ◽  
Vol 17 (6) ◽  
pp. 670-677 ◽  
Author(s):  
Emanuela Fabiola Craparo ◽  
Maria Luisa Bondì ◽  
Giovanna Pitarresi ◽  
Gennara Cavallaro
Keyword(s):  
Drug Delivery ◽  
Central Nervous System ◽  
Nervous System ◽  
The Central Nervous System ◽  
Nanoparticulate Systems

scholarly journals Interventional MRI-guided catheter placement and real time drug delivery to the central nervous system

2016 ◽  
Vol 16 (6) ◽  
pp. 635-639 ◽  
Author(s):  
Seunggu J. Han ◽  
Krystof Bankiewicz ◽  
Nicholas A. Butowski ◽  
Paul S. Larson ◽  
Manish K. Aghi
Keyword(s):  
Drug Delivery ◽  
Central Nervous System ◽  
Nervous System ◽  
Real Time ◽  
Interventional Mri ◽  
Catheter Placement ◽  
The Central Nervous System ◽  
Mri Guided

Drug delivery to the central nervous system

2021 ◽  
Author(s):  
Elizabeth Nance ◽  
Suzie H. Pun ◽  
Rajiv Saigal ◽  
Drew L. Sellers
Keyword(s):  
Drug Delivery ◽  
Central Nervous System ◽  
Nervous System ◽  
The Central Nervous System
Sign in / Sign up

Export Citation Format

Share Document